Results 1 to 10 of about 161,517 (244)

Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve [PDF]

, 2012
Background: The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti- inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle.
A Farkas, A Peretz, A Varró, A Varró, A Varró, AJ Batey, Andrea Barbuti, András Varró, Attila Kristóf, B Girennavar, B Scheidel, C Bombardier, C Lengyel, C Lengyel, CL Lawrence, Cs Lengyel, D Corrado, DM Roden, DM Roden, DM Roden, E Coraboeuf, EL Fosbøl, FI Al-Jenoobi, G Hart, HA Bird, István Baczkó, István Koncz, JH Lin, JJ Duncan, Julius Gy Papp, L Carlsson, L Virág, LI Brueggemann, LL von Moltke, LY Liu, László Virág, M Hidaka, M Niemi, MA Vos, N Jost, Norbert Jost, OV Yarishkin, P McGettigan, PG Volders, Péter Biliczki, R Bort, R Varkevisser, S Trelle, T Christ, Tamás Szél, Viktor Juhász, WF Huang, WF Huang, XW Fei, Y Lu, Zoltán Husti, Zsófia Kohajda   +56 more
core   +11 more sources

Effect of a delayed-action phenytoin preparation on blood phenytoin concentration [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1972
In a cross-over study in a group of epileptic patients it was shown that replacement of the evening dose of an ordinary phenytoin preparation with the same phenytoin dose in a delayed-action preparation produced no significant change in the next morning's mean blood phenytoin concentration.
Mervyn J. Eadie, John H. Tyrer, F. Bochner, Wayne D. Hooper   +3 more
openaire   +2 more sources

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Biliczki, Péter, Bitay, Miklós, Bogáts, Gábor, Jost, Norbert, Lathrop, David A., Lengyel, Csaba Attila, Nagy, Zsolt, Papp, Gyula, Takács, János, Varró, András, Virág, László   +10 more
core   +1 more source

Octopamine increases the excitability of neurons in the snail feeding system by modulation of inward sodium current but not outward potassium currents [PDF]

, 2005
Background: Although octopamine has long been known to have major roles as both transmitter and modulator in arthropods, it has only recently been shown to be functionally important in molluscs, playing a role as a neurotransmitter in the feeding network
Elliott, C J H, Szabo, H, Vehovszky, A
core   +3 more sources

Experimentally-calibrated population of models predicts and explains inter-subject variability in cardiac cellular\ud electrophysiology [PDF]

, 2013
Cellular and ionic causes of variability in the electrophysiological activity of hearts from individuals of the same species are unknown. However, improved understanding of this variability is key to enable prediction of the response of specific hearts ...
Britton, O.J., Bueno-Orovio, A., Gallacher, D.J., Lu, H.R., Rodriguez, B., Towart, R., van Ammel, K.   +6 more
core   +1 more source

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]

, 2017
Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi, Cecilia Giulivi, Eleonora Napoli, Francesca Galuppini, Genny Orso, Ilaria Marsilio, Isabella Lante, Maria Cecilia Giron, Massimo Rugge, Mona Roozfarakh, Silvia Cerantola, Silvia Cerantola, Valentina Caputi   +12 more
core   +3 more sources

Facilitation of transmitter release at squid synapses [PDF]

, 1978
Facilitation is shown to decay as a compound exponential with two time constants (T1, T2) at both giant and non-giant synapses in squid steilate ganglia bathed in solutions having low extracellular calcium concentrations ([Ca++]o).
Bittner, George D., Charlton, Milton P.
core   +1 more source

Role of tonic inhibition in associative reward condiitoning in Lymnaea [PDF]

, 2010
Changes in the strength of excitatory synaptic connections are known to underlie associative memory formation in the molluscan nervous system but less is known about the role of synaptic inhibition.
Benjamin, Paul R, Feng, Jianfeng, Kemenes, Ildikó, Marra, Vincenzo, O'Shea, Michael, Vavoulis, Dimitris   +5 more
core   +3 more sources

Abnormal Action Potentials Associated with the Shaker Complex Locus of Drosophila [PDF]

, 1981
Intracellular recordings of action potentials were made from the cervical giant axon in Shaker (Sh) mutants and normal Drosophila. The mutants showed abnormally long delays in repolarization.
Ferrus, Alberto, Fujita, Shinobu C., Tanouye, Mark A.   +2 more
core   +1 more source

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines [PDF]

, 2008
Krüppel-like transcription factors (Klfs) modulate fundamental cell processes. Cardiac myocytes are terminally-differentiated, but hypertrophy in response to stimuli such as endothelin-1. H2O2 or cytokines promote myocyte apoptosis. Microarray studies of
Ahmad, Andrew K. Marshall, Angela Clerk, Atkins, Bieker, Bilanges, Bogoyevitch, Boon, Chen, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Cook, Cullingford, Dang, Davies, Dorn, El Li Tham, Favata, Feinberg, Fisch, Ghaleb, Haldar, Hamik, Harrison, Inuzuka, Iwaki, Kaczynski, Kawai-Kowase, Kemp, Kennedy, Kojima, Kyriakis, Lavallée, Leung, Liu, Lomberk, Markou, Matthew J. Butler, Mody, Moriguchi, Ornatsky, Peter H. Sugden, Pham, Pham, Scohy, Sohn, Sugden, Sun, Suske, Suzuki, Timothy E. Cullingford, Uchida, van Thienen, van Vliet, Wani, Yang   +61 more
core   +2 more sources