Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve. [PDF]
PLoS ONE, 2012 BACKGROUND: The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle.
Attila Kristóf +11 more
doaj +10 more sources
Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]
Frontiers in Pharmacology, 2017 Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Valentina Caputi +12 more
doaj +5 more sources
Lysophosphatidic acid increases the electrophysiological instability of adult rabbit ventricular myocardium by augmenting L-type calcium current. [PDF]
PLoS ONE, 2012 Lysophosphatidic acid (LPA) has diverse actions on the cardiovascular system and is widely reported to modulate multiple ion currents in some cell types. However, little is known about its electrophysiological effects on cardiac myocytes.
Yong Wei +10 more
doaj +1 more source
U.S. patient preferences for long‐acting HIV treatment: a discrete choice experiment
Journal of the International AIDS Society, 2023 Introduction Recent advances in long‐acting antiretroviral therapy (LA‐ART) could provide new options for HIV treatment and reduce adherence barriers, if regimens are acceptable to patients.
Susan M. Graham +9 more
doaj +1 more source
Concerns regarding tablet splitting: a systematic review
BJGP Open, 2022 Background: Tablet splitting can provide dose flexibility and cost savings; however, pharmaceutical representatives typically discourage the practice. Aim: To identify and summarise all published concerns related to tablet splitting and to present the ...
Aanchal K Saran +2 more
doaj +1 more source
Acetylcholine Reduces IKr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes
Biomedicines, 2022 Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed.
István Koncz +10 more
doaj +1 more source
Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]
, 2005 Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Biliczki, Péter +10 more
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Ibrutinib and acalabrutinib are Bruton tyrosine kinase inhibitors used in the treatment of B‐cell lymphoproliferative disorders. Ibrutinib is associated with new‐onset atrial fibrillation.
Jari M. Tuomi +6 more
doaj +1 more source
Central pattern generator for swimming in Melibe [PDF]
, 2005 The nudibranch mollusc Melibe leonina swims by bending from side to side. We have identified a network of neurons that appears to constitute the central pattern generator (CPG) for this locomotor behavior, one of only a few such networks to be described ...
Thompson, Stuart, Watson, Winsor H., III
core +3 more sources
BMC Psychiatry, 2012 Background Current guidelines suggest specific criteria for oral or long-acting injectable antipsychotic drugs (LAIs). This review aims to describe the demographic and clinical characteristics of the ideal profile of the patient with schizophrenia ...
Rossi Giuseppe +3 more
doaj +1 more source