The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. [PDF]
PLoS ONE, 2016 In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca2+ transients, cell shortening and in experimental arrhythmias.
Zsófia Kohajda +25 more
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Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]
, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T +13 more
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Journal of Pharmacological Sciences, 2009 .: Propofol is a widely used intravenous general anesthetic. The negative inotropic effect of propofol has been best explained by inhibition of the L-type Ca2+ current (ICa).
Noboru Hatakeyama +7 more
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Pharmacological Modulation of Hif-1α in the Cerebral Cortex of Rats after Chronic Prenatal Hypoxia
Biology and Life Sciences Forum, 2022 Despite the significant advances in modern medicine, the problem of perinatal hypoxic CNS damage in children occupies one of the leading places in modern neonatology.
Olena G. Aliyeva +3 more
doaj +1 more source
Fermented mistletoe extract as a multimodal antitumoral agent in gliomas [PDF]
, 2012 In Europe, commercially available extracts from the white-berry mistletoe (Viscum album L.) are widely used as a complementary cancer therapy. Mistletoe lectins have been identified as main active components and exhibit cytotoxic effects as well as ...
Harter, Patrick Nikolaus +4 more
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Study on Neuromuscular Blockade Action of Verapamil in Albino Rats [PDF]
Journal of Clinical and Diagnostic Research, 2013 Background: Calcium Channel Blockers (CCBs) are now widely employed in the treatment of cardiovascular diseases and peri-operative hypertension. It has been reported that calcium channel blockers inhibit neuromuscular transmission.
JAYASHREE NAGARAL +6 more
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Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium [PDF]
, 2000 During atrial fibrillation, ventricular rate is determined by atrioventricular nodal (AVN) conduction, which in part is dependent upon the refractoriness of single AVN cells.
Andrew C. Rankin +48 more
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Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways. [PDF]
PLoS ONE, 2010 Proving the efficacy and corresponding mode of action of herbal supplements is a difficult challenge for evidence-based herbal therapy. A major hurdle is the complexity of herbal preparations, many of which combine multiple herbs, particularly when the ...
Young-Beob Yu +5 more
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Presynaptic facilitation at the crayfish neuromuscular junction: Role of calcium-activated potassium conductance [PDF]
, 1991 Membrane potential was recorded intracellularly near presynaptic terminals of the excitor axon of the crayfish opener neuromuscular junction (NMJ), while transmitter release was recorded postsynaptically.
Bittner, George D. +2 more
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Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients [PDF]
, 1993 Glucocorticoid hormones suppress the secretion of ACTH evoked by secretagogues such as CRF and arginine vasopressin. In this study, we investigated the effects of glucocorticoids on ACTH release induced by oxytocin (OT) and on intracellular free calcium ...
Dayanithi, G., Gratzl, Manfred, Link, H.
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