Results 1 to 10 of about 154,529 (215)

Functional mechanism and clinical implications of LINC00339 in delayed fracture healing [PDF]

Journal of Orthopaedic Surgery and Research
Objective Delayed fracture healing is a common complication of fractures that significantly impacts human health. This study aimed to explore the role of LINC00339 (lncRNA) in delayed fracture healing to provide new directions for its treatment.
Yuntao Li, Ya Sun, Ke Ma, Shengqian Wang, Zhibiao Wang, Lina Huang   +5 more
doaj   +6 more sources

Exploring the role of OIP5-AS1 in the mechanisms of delayed fracture healing: functional insights and clinical implications [PDF]

Journal of Orthopaedic Surgery and Research
Objective Fracture is a common traumatic disease and there is a risk of delayed healing after fracture occurs. This study aimed to explore the regulatory roles and clinical implications of OIP5-AS1 in delayed fracture healing.
Yusen Hu, Meini Cen, Yi Hu
doaj   +4 more sources

LncRNA SNHG1 Delayed Fracture Healing via Modulating miR-181a-5p/PTEN Axis

Journal of Investigative Surgery, 2022
Background:The purpose of this study was to investigate the role of Long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) in delayed healing of tibial fractures and its potential regulatory mechanisms.
Xiuquan Guo, Jialiang Zhang, Xuemei Han, Ganggang Wang   +3 more
doaj   +4 more sources

Biological perspectives of delayed fracture healing [PDF]

Injury, 2014
Fracture healing is a complex biological process that requires interaction among a series of different cell types. Maintaining the appropriate temporal progression and spatial pattern is essential to achieve robust healing. We can temporally assess the biological phases via gene expression, protein analysis, histologically, or non-invasively using ...
K D, Hankenson, G, Zimmerman, R, Marcucio   +2 more
semanticscholar   +4 more sources

Fracture healing physiology and the quest for therapies for delayed healing and nonunion [PDF]

Journal of Orthopaedic Research, 2016
ABSTRACTDelayed healing and nonunion of fractures represent enormous burdens to patients and healthcare systems. There are currently no approved pharmacological agents for the treatment of established nonunions, or for the acceleration of fracture healing, and no pharmacological agents are approved for promoting the healing of closed fractures.
Kostenuik, Paul, Mirza, Faisal M.
semanticscholar   +6 more sources

lncRNA CASC11 regulates the progress of delayed fracture healing via sponging miR-150-3p [PDF]

Journal of Orthopaedic Surgery and Research
Background Long non-coding RNA (lncRNA) plays a pivotal role in bone regeneration by interaction with microRNAs (miRNAs) and constructing a lncRNA-miRNA regulatory network.
Xiaoming Wu, Tuwang Shen, Wenjun Ji, Miao Huang, Jincheng Sima, Jin Li, Hao Song, Wei Xiong, Meini Cen   +8 more
doaj   +3 more sources

Continuous infusion of PTH1–34 delayed fracture healing in mice [PDF]

Scientific Reports, 2018
AbstractHyperparathyroidism, which is increased parathyroid hormone (PTH) levels in the blood, could cause delayed or non-union of bone fractures. But, no study has yet demonstrated the effects of excess continuous PTH exposure, such as that seen in hyperparathyroidism, for fracture healing.
Kiminori Yukata, Tsukasa Kanchiku, Hiroshi Egawa, Michihiro Nakamura, Norihiro Nishida, Takahiro Hashimoto, Hiroyoshi Ogasa, Toshihiko Taguchi, Natsuo Yasui   +8 more
semanticscholar   +4 more sources

Delayed Tibial Shaft Fracture Healing Associated with Smoking: A Systematic Review and Meta-Analysis of Observational Studies Conducted Worldwide

International Journal of Environmental Research and Public Health, 2021
Tibial fractures represent a great burden of disease globally, being the most common long-bone fracture; smoking is a known risk factor for delayed skeletal healing and post-fracture complications. This systematic review and meta-analysis aims to analyse
Akanksha Mahajan, Narinder Kumar, Bhawna Gupta   +2 more
exaly   +3 more sources

HIF-stabilization prevents delayed fracture healing [PDF]

bioRxiv, 2020
Abstract The initial phase of fracture healing decides on success of bone regeneration and is characterized by an inflammatory milieu and low oxygen tension (hypoxia). Negative interference with or prolongation of this fine-tuned initiation phase will ultimately lead to a delayed or incomplete healing such as non ...
Annemarie Lang, Sarah Helfmeier, Jonathan Stefanowski, Aditi Kuppe, Vikram Sunkara, Moritz Pfeiffenberger, Angelique Wolter, Alexandra Damerau, Shabnam Hemmati-Sadeghi, Jochen Ringe, Rainer Haag, Anja E. Hauser, Max Löhning, Carsten Perka, Georg N. Duda, Paula Hoff, Katharina Schmidt-Bleek, Timo Gaber, Frank Buttgereit   +18 more
openaire   +2 more sources

Effects of delayed stabilization on fracture healing [PDF]

Journal of Orthopaedic Research, 2007
AbstractPrevious studies have revealed that delayed internal fixation can stimulate fracture callus formation and decrease the rate of nonunion. However, the effect of delayed stabilization on stem cell differentiation is unknown. To address this, we created fractures in mouse tibiae and applied external fixation immediately, at 24, 48, 72, or 96 h ...
Chuanyong Lu, Paul Choi, Christian M Puttlitz   +2 more
exaly   +3 more sources