Results 11 to 20 of about 154,529 (215)
CXCR4 Antagonism to Treat Delayed Fracture Healing [PDF]
Tissue Engineering Part A, 2019 A significant number of fractures develop nonunion. Stem cell homing is regulated through stromal cell-derived factor 1 (SDF1) and its receptor CXCR4. Stem/progenitor cell populations can be endogenously mobilized by administering growth factors with a pharmacological antagonist of CXCR4, AMD3100, which may be a means to improve ...
Meeson, Richard +3 more
core +6 more sources
Fracture Healing Is Delayed in Immunodeficient NOD/scid‑IL2Rγcnull Mice. [PDF]
PLoS ONE, 2016 Following bone fracture, the repair process starts with an inflammatory reaction at the fracture site. Fracture healing is disturbed when the initial inflammation is increased or prolonged, whereby, a balanced inflammatory response is anticipated to be ...
Anna E Rapp +8 more
doaj +3 more sources
Fracture healing research: Recent insights
Bone Reports, 2023 Bone has the rare capability of scarless regeneration that enables the complete restoration of the injured bone area. In recent decades, promising new technologies have emerged from basic, translational and clinical research for fracture treatment ...
Lena Steppe +4 more
doaj +3 more sources
Research advances of nanomaterials for the acceleration of fracture healing
Bioactive Materials, 2023 The bone fracture cases have been increasing yearly, accompanied by the increased number of patients experiencing non-union or delayed union after their bone fracture.
Mo Zhang +7 more
doaj +3 more sources
LncRNA MAGI2-AS3 promotes fracture healing through downregulation of miR-223-3p
Journal of Orthopaedic Surgery and ResearchBackground Long non-coding RNAs (LncRNAs) are recognized as a pivotal element in the processes of fracture healing and the osteogenic differentiation of stem cells.
Zhiqiang Dong +7 more
doaj +3 more sources
PLoS ONE, 2014 Introduction Impaired healing and non-union of skeletal fractures is a major public health problem, with morbidity exacerbated in patients with diabetes mellitus (DM).
Matthew L Brown +2 more
exaly +4 more sources
Glucocorticoid-induced delayed fracture healing and impaired bone biomechanical properties in mice [PDF]
Clin Interv Aging, 2018 Background The objective of the study was to investigate the effects of glucocorticoid (GC) on the fracture healing process in a closed femur fracture mice model.
Yan-zhi Liu +10 more
semanticscholar +2 more sources
Impairment of maturation of BMP-6 (35 kDa) correlates with delayed fracture healing in experimental diabetes [PDF]
J Orthop Surg Res, 2020 Background: Although it is known that diabetes interferes with fracture healing, the mechanisms remain poorly understood. The aim of this study was to investigate the correlation of BMP-6 and BMP-9 with the impairment in fracture healing in diabetes, by ...
Guo, Zheng +3 more
core +2 more sources
Disturbed remodeling and delayed fracture healing in pediatric pycnodysostosis patients [PDF]
J Orthop, 2019 Pycnodysostosis is an autosomal recessive disease caused by a gene mutation leading cathepsin K deficiency. Pathological fractures of the long bones are common, but guidelines on fracture treatment in these patients are still lacking.
Savci-Heijink, C. Dilara +3 more
core +2 more sources
Bone ResearchSkeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but the causes of SSPC senescence remain unclear.
Nan-Yu Zou +20 more
doaj +2 more sources