Results 31 to 40 of about 154,529 (215)

Current modalities for fracture healing enhancement

, 2021
Previously, most fractures have been treated through bone reduction and immobilization. With an increase in the patients' need for an early return to their normal function, development in surgical techniques and materials have accelerated.
Won, Tae Gu, Kim, Yuna, Chun, You Seung, Shetty, Asode Ananthram, Lee, Dong Hwan, Kim, S.   +5 more
core   +1 more source

EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: a NICE medical technology guidance [PDF]

, 2014
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are ...
Meads, C., Higgins, Ailish, Higgins, A, Lord, J., Meads, Catherine, Yang, Y, Bayliss, S, Glover, M, Glover, Matthew, Yang, Y., Bayliss, S., Lord, Joanne, Higgins, A., Bayliss, Susan, Yang, Yaling, Lord, J, Meads, C, Glover, M.   +17 more
core   +1 more source

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. [PDF]

PLoS ONE, 2014
The growth and differentiation factor midkine (Mdk) plays an important role in bone development and remodeling. Mdk-deficient mice display a high bone mass phenotype when aged 12 and 18 months. Furthermore, Mdk has been identified as a negative regulator
Melanie Haffner-Luntzer, Aline Heilmann, Anna Elise Rapp, Simon Beie, Thorsten Schinke, Michael Amling, Anita Ignatius, Astrid Liedert   +7 more
doaj   +1 more source

Correlation of serum PTH level and fracture healing speed in elderly patients with hip fracture

Journal of Orthopaedic Surgery and Research, 2019
Purpose To access serum parathyroid hormone (PTH) level in elderly patients with hip fracture in relation to fracture healing outcomes. Methods This study included 90 elderly male patients with hip fracture and they were defined as the hip fracture group,
Zhao-Nan Ban, Zheng-Jiang Li, Qi-Shan Gu, Jun Cheng, Qiang Huang, Shu-Xing Xing   +5 more
doaj   +1 more source

Diclofenac, a NSAID, delays fracture healing in aged mice

Experimental Gerontology, 2023
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, belong to the most prescribed analgesic medication after traumatic injuries. However, there is accumulating evidence that NSAIDs impair fracture healing. Because bone regeneration in aged patients is subject to significant changes in cell differentiation and proliferation as well as a ...
Menger, Maximilian M., Stief, Maximilian, Scheuer, Claudia, Rollmann, Mika F., Herath, Steven C., Braun, Benedikt J., Ehnert, Sabrina, Nussler, Andreas K., Menger, Michael D., Laschke, Matthias W., Histing, Tina   +10 more
openaire   +3 more sources

Osseous Consolidation of an Aseptic Delayed Union of a Lower Leg Fracture after Parathyroid Hormone Therapy – A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
The absence of osseous consolidation of a fracture within the normal time period is defined as delayed union or non-union. Both for the patient and from a socio-economic point of view, impaired fracture healing represents a major problem.
Ilko Kastirr, Sebastian Radmer, Reimer Andresen, Hans-Christof Schober   +3 more
doaj   +1 more source

Delayed Union of a Diaphyseal Forearm Fracture Associated With Impaired Osteogenic Differentiation of Prospectively Isolated Human Skeletal Stem Cells

JBMR Plus, 2020
Delayed union or nonunion are relatively rare complications after fracture surgery, but when they do occur, they can result in substantial morbidity for the patient.
L Henry Goodnough, Thomas H Ambrosi, Holly Steininger, Malcolm R DeBaun, Geoffrey D Abrams, Timothy R McAdams, Michael J Gardner, Charles KF Chan, Julius A Bishop   +8 more
doaj   +1 more source

Delayed healing of lower limb fractures with bisphosphonate therapy [PDF]

The Annals of The Royal College of Surgeons of England, 2015
Introduction Bisphosphonate therapy (BT) is used commonly in the management of osteoporosis. A systematic review was conducted investigating delayed union of lower limb, long bone fractures in patients on BT. We specifically assessed whether BT increases the risk of delayed union or non-union in lower limb, long bone fractures.
B, Yue, A, Ng, H, Tang, S, Joseph, M, Richardson   +4 more
openaire   +2 more sources

M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator

Bioactive Materials, 2023
Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing. Macrophages play a key role in the process of fracture healing by undergoing polarization into either M1 or M2 subtypes, which respectively exhibit pro ...
Yili Wang, Qiushui Lin, Hao Zhang, Sicheng Wang, J. Cui, Yan Hu, Jinlong Liu, Mengmeng Li, Kun Zhang, Fengjin Zhou, Yingying Jing, Zhen Geng, Jiacan Su   +12 more
semanticscholar   +1 more source

Fracture healing is delayed in the absence of gasdermin signaling [PDF]

, 2021
Abstract Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18. Excessive GSDM- mediated pore formation can compromise the integrity of the plasma membrane thereby causing the lytic inflammatory cell death ...
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D. Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J. Silva, Jie Shen, Gabriel Mbalaviele   +12 more
openaire   +1 more source