Results 51 to 60 of about 154,529 (215)

Assessment of tibial fracture healing with dual energy X-ray absorptiometry: influence of metallic implants at the fracture site [PDF]

, 1995
Evaluation of the progress of fracture healing traditionally combines manual fracture manipulation with a visual radiographic assessment. This approach can lead to satisfactory healing, but trouble can ensue when the type of fixation compromises the ...
Cattermole, Howard Charles
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Systemic response of the GH/IGF-I axis in timely versus delayed fracture healing

, 2008
The GH-IGF axis has profound effects on the local and systemic regulation of bone metabolism and may be important for quality of fracture healing. To test the hypothesis that deficiency of the GH/IGF axis may play a role in the pathogenesis of fracture ...
Bidlingmaier, M, Stefan Weiss, Moghaddam, A, Kasten, P, Weiss, S, Zimmermann, G, Arash Moghaddam, Philip Kasten, Martin Bidlingmaier, Gerald Zimmermann, Henle, P, Philipp Henle   +11 more
core   +1 more source

NLRP3 inflammasome impairs fracture repair in Rheumatoid arthritis through RhoA/Rac1-IL1β axis-mediated suppression of osteoblast differentiation

Journal of Orthopaedic Translation
Objective: Rheumatoid arthritis (RA) is often characterized by bone loss and fragility fractures and is a frequent comorbidity. The NLRP3 inflammasome drives inflammatory processes that fundamentally accompany the pathogenesis of RA. However, the role of
Fen Miao, Hanjia Cai, Yue Chen, Ziwei Yan, Ruofan Jin, Yueming Dai, Lu Li, Hua Wang, Yan Xu, Wen Sun   +9 more
doaj   +1 more source

Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice

Journal of Clinical Investigation, 2022
Cellular senescence plays an important role in human diseases, including osteoporosis and osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory phenotype to affect the function of neighboring cells and SCs themselves.
Jiatong Liu, Jun Zhang, Xi Lin, B. Boyce, Hengwei Zhang, L. Xing   +5 more
semanticscholar   +1 more source

[TGF-beta1 as a pathophysiological factor in fracture healing]

, 2007
AIM: TGF-beta1 is an important local and systemic regulatory molecule during fracture healing. Various authors have shown differences in the systemic levels of TGF-beta1 over the time taken for bone healing in distraction osteogenesis and osteotomies ...
Moghaddam, A, Zimmermann, G, Weiss, S, Breier, L, Wentzensen, A, Wangler, B, Henle, P, Reumann, M   +7 more
core   +1 more source

Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p/Bmp2

Journal of Orthopaedic Surgery and Research
Objective Delayed fracture healing increases the suffering of patients. An in-depth investigation of the pathogenesis of delayed fracture healing may offer new direction for the prevention and treatment.
Renjie Kang, Lina Huang, Teng Zeng, Jinliang Ma, Danjie Jin   +4 more
doaj   +1 more source

Risk factor analysis for delayed union after subtrochanteric femur fracture: quality of reduction and valgization are the key to success

BMC Musculoskeletal Disorders, 2019
Background Subtrochanteric femur fractures (SFF) are uncommon, but have a high complication rate concerning non-union and mechanical complications. There is ongoing discussion about risk factors for delayed fracture healing after SFF. The purpose of this
Viola Freigang, Franziska Gschrei, Himanshu Bhayana, Paul Schmitz, Johannes Weber, Maximilian Kerschbaum, Michael Nerlich, Florian Baumann   +7 more
doaj   +1 more source

Delayed tibial shaft fracture healing associated with smoking: A systematic review and meta‐analysis of observational studies conducted worldwide

, 2022
 Tibial fractures represent a great burden of disease globally, being the most common long-bone fracture; smoking is a known risk factor for delayed skeletal healing and post‐fracture complications.
Bhawna Gupta (5934965)
core   +1 more source

Cyclooxygenase-2 inhibitor delays fracture healing in rats

Acta Orthopaedica, 2005
Cyclooxigenase-2 (COX-2) inhibitors have been reported to delay fracture healing. To investigate the major inhibitory period of COX-2 inhibitors in fracture healing, we administrated etodolac, a COX-2-specific inhibitor, to a rat fracture model by altering the period of administration from early to late.After closed fractures had been created at the ...
Kenji, Endo, Koichi, Sairyo, Shinji, Komatsubara, Takahiro, Sasa, Hiroshi, Egawa, Takayuki, Ogawa, Daisuke, Yonekura, Ri-Ichi, Murakami, Natsuo, Yasui   +8 more
openaire   +2 more sources

Molecular factors involved in the development of diabetic foot syndrome [PDF]

, 2012
Diabetes is one of the major challenges of modern medicine, as it is considered a global epidemic of the XXI century. The disease often leads to the development of serious, health threatening complications.
Brun-Olszewska, Bożena, Olszewski, Paweł, Bruhn-Olszewska, Bożena, Węgrzyn, Alicja, Gabig-Cimińska, Magdalena, Korzon-Burakowska, Anna, Jakóbkiewicz-Banecka, Joanna   +6 more
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