Synthesis of Oxazolidinones by a Hypervalent Iodine Mediated Cyclization of N‐Allylcarbamates [PDF]
Advanced Synthesis &Catalysis, Volume 363, Issue 6, Page 1646-1650, March 16, 2021., 2021 The preparation of oxazolidinones by the hypervalent iodine mediated cyclization of allylcarbamates is described. A versatile range of substrates can be converted into substituted oxazolidinones primed for further transformations.
Das, Mirdyul +3 more
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Comparative In Vitro Drug Susceptibility Study of Five Oxazolidinones Against Mycobacterium tuberculosis in Hainan, China [PDF]
PathogensOxazolidinones, novel synthetic antibacterials, inhibit protein biosynthesis and show potent activity against Gram-positive bacteria, including Mycobacterium tuberculosis (MTB).
Jinhui Dong +9 more
doaj +2 more sources
Treatment for non-tuberculous mycobacteria: challenges and prospects. [PDF]
Front MicrobiolNon-Tuberculous mycobacteria (NTM) are opportunistic environmental bacteria. Globally, NTM incidence is increasing and modeling suggests that, without new interventions, numbers will continue to rise.
Conyers LE, Saunders BM.
europepmc +3 more sources
Bridging science and policy in tuberculosis treatment through innovations in precision medicine, drug development, and cohort research: a narrative review. [PDF]
Ewha Med JRecent advancements in tuberculosis treatment research emphasize innovative strategies that enhance treatment efficacy, reduce adverse effects, and adhere to patient-centered care principles. As tuberculosis remains a significant global health challenge,
Min J, Andrade BB, Kim JS, Jeong Y.
europepmc +3 more sources
Contezolid Harbored Equivalent Efficacy to Linezolid in Tuberculosis Treatment in a Prospective and Randomized Early Bactericidal Activity Study. [PDF]
Infect Drug ResistGuanglu Jiang,1,* Rongmei Liu,2,* Yi Xue,1 Qiping Ge,2 Lihui Nie,2 Zizheng Lv,2 Zhongshun Kong,2 Jin Shi,2 Hongmei Chen,2 Hua Li,2 Xiaoguang Wu,2 Li Xie,2 Yanhua Song,2 Hairong Huang,1 Mengqiu Gao2 1National Clinical Laboratory on Tuberculosis ...
Jiang G +14 more
europepmc +3 more sources
International Journal of Infectious Diseases, 2021 Background: The natural resistance of rapidly growing mycobacteria (RGM) to multiple antibiotics renders the treatment of the infections caused less successful.
Shu’an Wen +9 more
doaj +1 more source
Mycobacterium tuberculosis: Pathogenesis and therapeutic targets
MedComm, Volume 4, Issue 5, October 2023., 2023 In this review, we summarize the pathogenesis of TB infection, therapeutic targets, and corresponding modulators, including first‐line medications, current clinical trial drugs and molecules in preclinical assessment. Our review provides valuable insights for future antituberculosis drug development efforts.
Jiaxing Yang +3 more
wiley +1 more source
An Overview of Bioactive 1,3-Oxazole-Containing Alkaloids from Marine Organisms
Pharmaceuticals, 2021 1,3-Oxazole chemicals are a unique class of five-membered monocyclic heteroarenes, containing a nitrogen atom and an oxygen. These alkaloids have attracted extensive attention from medicinal chemists and pharmacologists owing to their diverse arrays of ...
Jinyun Chen +5 more
doaj +1 more source
Advances in Key Drug Target Identification and New Drug Development for Tuberculosis
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control. Therefore, there is an urgent need to develop new anti‐TB drugs to treat drug‐resistant TB and shorten the standard therapy.
Jie Mi +3 more
wiley +1 more source
MDR Tuberculosis Treatment [PDF]
, 2022 MDR; Tratamiento; TuberculosisMDR; Tractament; TuberculosiMDR; Treatment; TuberculosisMultidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues to be one of the most important threats to controlling the TB epidemic ...
Aznar, Maria Luisa +4 more
core +2 more sources