Results 21 to 30 of about 237 (77)

Mycobacterium tuberculosis: Pathogenesis and therapeutic targets

MedComm, Volume 4, Issue 5, October 2023., 2023
In this review, we summarize the pathogenesis of TB infection, therapeutic targets, and corresponding modulators, including first‐line medications, current clinical trial drugs and molecules in preclinical assessment. Our review provides valuable insights for future antituberculosis drug development efforts.
Jiaxing Yang, Laiying Zhang, Wenliang Qiao, Youfu Luo   +3 more
wiley   +1 more source

Advances in Key Drug Target Identification and New Drug Development for Tuberculosis

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control. Therefore, there is an urgent need to develop new anti‐TB drugs to treat drug‐resistant TB and shorten the standard therapy.
Jie Mi, Wenping Gong, Xueqiong Wu, Atef M. Al Attar   +3 more
wiley   +1 more source

Synthesis of Oxazolidinones by a Hypervalent Iodine Mediated Cyclization of N‐Allylcarbamates

Advanced Synthesis &Catalysis, Volume 363, Issue 6, Page 1646-1650, March 16, 2021., 2021
Abstract The preparation of oxazolidinones by the hypervalent iodine mediated cyclization of allylcarbamates is described. A versatile range of substrates can be converted into substituted oxazolidinones primed for further transformations. Derivatization of the products at both ends is demonstrated.
Mirdyul Das, Arantxa Rodríguez, Pui Kin Tony Lo, Wesley J. Moran   +3 more
wiley   +1 more source

Pipeline of anti-Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities [PDF]

Medicinal Research Reviews, 2021
Vadim A Makarov, Anna Egorova, Mary Jackson   +2 more
exaly   +2 more sources

폐결핵 환자 대상 Delpazolid 의 약동, 약력학 모델링 분석

, 2023
Objective: Delpazolid (LCB01-0371) is a novel and safe oxazolidinone derivative for the treatment of infection by gram-positive pathogens. Especially, Delpazolid is effective against several M.abscessus which is a highly pathogenic drug-resistant ...
이상민
core  

Searching for Ideal Oxazolidinone for Treatment of Tuberculosis

Туберкулез и болезни лёгких
Oxazolidinones represent a promising class of drugs for treatment of multidrug-resistant tuberculosis (MDR-TB). Linezolid, the first representative of this class, is highly effective; however, its use is limited due to its toxicity (myelosuppression ...
A. I. Gayda, G. N. Mozhokina, E. R. Pereverzeva, M. I. Romanova, A. V. Abramchenko, A. G. Samoylova   +5 more
doaj   +1 more source

Structural modification of oxazolidinone antibiotics alters nascent peptide stalling preference and peptide trajectory through the ribosome

The oxazolidinone antibiotic linezolid binds to the peptidyl transferase center of the ribosome, where it inhibits a subset of peptide bond formation events.
V\ue1zquez-Laslop, Nora, Fraser, James S., Fujimori, Danica Galoni\u107, Kleinman, Jordan I., Szal, Teresa, Raskar, Tushar, Mankin, Alexander S., Klepacki, Dorota   +7 more
core   +1 more source

Antimicrobial Effect of Oxazolidinones and Its Synergistic Effect with Bedaquiline Against Mycobacterium abscessus Complex. [PDF]

Infect Drug Resist, 2023
Gao T, Yao C, Shang Y, Su R, Zhang X, Ren W, Li S, Shu W, Pang Y, Li Q.   +9 more
europepmc   +1 more source

Advances in Diagnostics and Drug Discovery against Resistant and Latent Tuberculosis Infection. [PDF]

Pharmaceutics, 2023
Shleider Carnero Canales C, Marquez Cazorla J, Furtado Torres AH, Monteiro Filardi ET, Di Filippo LD, Costa PI, Roque-Borda CA, Pavan FR.   +7 more
europepmc   +1 more source

Staph wars: the antibiotic pipeline strikes back. [PDF]

Microbiology (Reading), 2023
Douglas EJA, Laabei M.
europepmc   +1 more source