Results 61 to 70 of about 266,371 (307)

Cognitive impairment in older people: its implications for future demand for services and costs [PDF]

, 2003
This study aimed to make projections, for the next 30 years, of future numbers of older people with cognitive impairment, their demand for long-term care services and the future costs of their care under a range of specified assumptions.

core  

Macrophages come to mind as keys to cognitive decline [PDF]

, 2016
Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by Faraco et al.
D.G. Harrison, Davies, Faraco, Launer, Liu, Tomasz J. Guzik   +5 more
core   +1 more source

Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study [PDF]

, 2020
Path integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer’s disease (AD). However, such path integration changes have been less explored in Vascular Cognitive Impairment (VCI), despite ...
Coughlan, Gillian, Hornberger, Michael, Jeffs, Stephen, Lowry, Ellen, Puthusseryppady, Vaisakh   +4 more
core   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Big data and data repurposing – using existing data to answer new questions in vascular dementia research [PDF]

, 2017
Introduction: Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost efficient hypothesis generating ...
A Abdul-Rahim, AH Noel-Storr, Andreas Charidimou, Charlotte J. Roberts, CN Martyn, Craig W. Ritchie, CW Ritchie, D Jang, D Kerr, D Religa, DA Levine, Deborah A. Levine, Fergus N. Doubal, G Mead, G Perera, G Perera, G Rands, G. David Batty, GE Mead, Gillian Mead, HA Mucke, Hermann A. M. Mucke, HL Dunn, I Chalmers, J Danesh, J Mindell, J Sultana, JPA Ioannidis, L Gray, M Ali, M Brainin, M Jokela, M Porter, M Porter, Maria Eriksdotter, Martin Hofmann-Apitius, Myzoon Ali, NL Catlett, P Langhorne, R Lees, R Patel, R Stewart, R Xu, Robert Stewart, S Garcia-Ptacek, SK McCann, T Hoffman, T Skillbäck, TC Russ, TC Russ, TC Russ, TC Russ, Terence J. Quinn, TJ Quinn, Tom C. Russ, William Whiteley, Yun-Hee Kim   +56 more
core   +8 more sources

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Age Related Changes in Cerebrovascular Reactivity and Its Relationship to Global Brain Structure [PDF]

, 2015
ACKNOWLEDGMENTS This study was funded by Alzheimer’s Research UK (ARUK) and the Aberdeen Biomedical Imaging Centre, University of Aberdeen. GDW, ADM and CS are part of the SINASPE collaboration (Scottish Imaging Network - A Platform for Scientific ...
Ahearn, Trevor S., Cameron, George G., Murray, Alison D., Schwarzbauer, Christian, Waiter, Gordon D.   +4 more
core   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source

Association of MAFLD and MASLD with all-cause and cause-specific dementia: a prospective cohort study

Alzheimer’s Research & Therapy
Background Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations between metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated ...
Xue Bao, Lina Kang, Songjiang Yin, Gunnar Engström, Lian Wang, Wei Xu, Biao Xu, Xiaowen Zhang, Xinlin Zhang   +8 more
doaj   +1 more source

Association of N-terminal pro-brain natriuretic peptide with cognitive function and depression in elderly people with type 2 diabetes [PDF]

, 2012
<p>Background: Type 2 diabetes mellitus is associated with risk of congestive heart failure (CHF), cognitive dysfunction and depression. CHF itself is linked both to poor cognition and depression.
,, Deary, Ian, Feinkohl, Insa, Price, Jackie F., Reynolds, Rebecca M., Sattar, Naveed, Strachan, Mark W. J., Welsh, Paul   +7 more
core   +2 more sources