Results 51 to 60 of about 39,887 (295)

Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia [PDF]

, 2020
BACKGROUND: We investigated the structural changes associated with Alzheimer's disease, dementia with Lewy bodies and Parkinson disease dementia by means of cortical thickness analysis.
Watson, R, Taylor, JP, Colloby, SJ, Blamire, AM, O’Brien, JT   +4 more
core   +1 more source

Dementia with Lewy Bodies.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2000
Dementia with Lewy bodies (DLB), the second most frequent cause of primary degenerative dementias following Alzheimer's disease, has been increasingly recognized since the proposal of the consensus name and clinical diagnostic criteria. Although DLB overlaps in clinical, pathological, and genetic features with Alzheimer's disease and Parkinson's ...
openaire   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis

Parkinson's Disease, 2012
Dementia is a common feature in Parkinson’s disease (PD) and is considered to be the result of limbic and cortical Lewy bodies and/or Alzheimer changes.
Simone A. van den Berge, Josta T. Kevenaar, Jacqueline A. Sluijs, Elly M. Hol   +3 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Semantic memory is impaired in both dementia with Lewy Bodies (DLB) and dementia of Alzheimer's type (DAT): a comparative neuropsychological study and literature review [PDF]

, 2001
OBJECTIVE---To test the hypothesis that semantic impairment is present in both patients with dementia with Lewy bodies (DLB) and those with dementia of Alzheimer's type (DAT).
Whitworth, A.B., Garrard, P., Garrard, P, Powell, J., Hodges, J.R., Lambon Ralph, Matthew, Howard, D., Howard, D, Lambon Ralph, M.A., Hodges, J., Powell, J, Whitworth, A   +11 more
core  

Differentiation Between Dementia With Lewy Bodies And Alzheimer’s Disease Using Voxel-Based Morphometry Of Structural MRI:AMulticenter Study

, 2019
Dementia with Lewy bodies (DLB) is one of the main etiologies of neurodegenerative dementia after Alzheimer’s disease (AD).1 Distinguishing DLB from AD is difficult because of their overlapping clinical and pathological features.2–4 Patients with ...
Asada, Takashi, Sato, Noriko, Ono, Tetsutaro, Yokoyama, Kota, Shigemori, Keiko, Mizumura, Sunao, 1001984, Hiroshi, Matsuda, 1001983, 1001986, Goto, Tomoaki, 1001985, 1001980, Nakatsuka, Tomoya, 1001982, 1001981, Matsuda, Hiroshi, Kanetaka, Hidekazu, 1001988, 1001987, Hanyu, Haruo, 1001989, Nemoto, Kiyotaka, Ito, Kengo, Terada, Hitoshi, 1001973, 1001972, 1001975, 1001974, Kawakatsu, Shinobu, 1001971, Hayashi, Hiroshi, 1001970, Shimada, Hitoshi, 1001977, 1001976, 1001979, 1001978, Suhara, Tetsuya, Oba, Hiroshi, Shinotoh, Hitoshi, Tetsuya, Suhara, 1001964, 1001969, 1001966, 1001965, 1001968, Hitoshi, Shinoto, 1001967, Hitoshi, Shimada, Kitamura, Shin   +50 more
core   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Cerebral Microbleeds in Patients with Dementia with Lewy Bodies and Parkinson Disease Dementia. [PDF]

, 2015
BACKGROUND AND PURPOSE: The burden of amyloid β is greater in patients with dementia with Lewy bodies than in those with Parkinson disease dementia, and an increased amyloid β load is closely related to a higher incidence of cerebral microbleeds.
Kim, SW, Chung, SJ, Kim, JS, Sunwoo, MK, Oh, YS, Hong, JY, Lee, PH, Yoon, JH   +7 more
core   +2 more sources

Listening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023
The regulatory path for drug approval is increasingly well defined. Drugs for the treatment of Alzheimer disease (AD) need to show statistically significant benefit over placebo with respect to cognitive and functional measures, with the Clinical ...
Marwan N. Sabbagh, Angela Taylor, Douglas Galasko, James E. Galvin, Jennifer G. Goldman, James B. Leverenz, Kathleen L. Poston, Bradley F. Boeve, David J. Irwin, Joseph F. Quinn   +9 more
doaj   +1 more source