Results 91 to 100 of about 43,841 (247)

The histone demethylase activity of Rph1 is not essential for its role in the transcriptional response to nutrient signaling.

open access: yesPLoS ONE, 2014
Rph1 and Gis1 are two related yeast zinc finger proteins that function as downstream effectors in the Ras/PKA, TOR and Sch9 nutrient signaling pathways.
Niklas Nordberg   +5 more
doaj   +1 more source

Molecular characterization reveals no functional evidence for naturally occurring cross‐kingdom RNA interference in the early stages of Botrytis cinerea–tomato interaction

open access: yesMolecular Plant Pathology, Volume 24, Issue 1, Page 3-15, January 2023., 2023
Botrytis cinerea mutants lacking both Dicer‐like genes displayed a >99% reduction of transposable element‐derived small RNA (sRNA) production, but were not reduced in virulence, indicating redundancy of sRNAs in fungal virulence. Abstract Plant immune responses are triggered during the interaction with pathogens.
Si Qin   +11 more
wiley   +1 more source

Design, Synthesis, and In Silico Insights of new 4‐Piperazinylquinolines as Antiproliferative Agents against NCI Renal Cancer Cell Lines

open access: yesChemistryOpen, EarlyView.
A novel series of hybrid 4‐(4‐benzoylpiperazin‐1‐yl)‐6‐nitroquinoline‐3‐carbonitrile derivatives has been designed, synthetized and evaluated for anticancer properties on the NCI60 panel. Strong antiproliferative effects have been detected against renal cancer cells.
Gabriele La Monica   +4 more
wiley   +1 more source

SPINDLY interacts with EIN2 to facilitate ethylene signalling‐mediated fruit ripening in tomato

open access: yesPlant Biotechnology Journal, Volume 21, Issue 1, Page 219-231, January 2023., 2023
SlSPY regulates fruit ripening by changing the ethylene response in tomato. A central regulator of ethylene signaling SlEIN2 as a SlSPY interacting protein regulates fruit ripening. SlSPY as an O‐glycosylation enzyme promotes the stability and nuclear accumulation of SlEIN2. SlEIN2 is required for the function of SlSPY in fruit ripening.
Jin Xu   +7 more
wiley   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Different nontarget‐site mechanisms underlie resistance to dicamba and 2,4‐D in an Amaranthus tuberculatus population

open access: yesPest Management Science, EarlyView.
Weak phenotypic and genetic associations between resistance to dicamba and 2,4‐D suggest that different nontarget‐site mechanisms contribute to these traits in an Amaranthus tuberculatus population from Illinois. Abstract BACKGROUND Amaranthus tuberculatus (Moq.) Sauer (waterhemp) has emerged as one of several weed species that is resistant to ...
Isabel Schlegel Werle   +5 more
wiley   +1 more source

DNA Demethylase Is a Processive Enzyme [PDF]

open access: hybrid, 1999
Nadia Cervoni   +2 more
openalex   +1 more source

Targeting KDM1A suppresses G6PD expression to induce oxidative stress and ferroptosis in TP53‐mutated liver cancer

open access: yesVIEW, EarlyView.
TP53‐mutant HCC is aggressive and often resistant to treatment. In this study, we found that KDM1A is highly expressed in TP53‐mutant HCC and promotes tumor growth while preventing ferroptosis by activating the pentose phosphate pathway (PPP). Targeting KDM1A, especially in combination with sorafenib, may offer a promising therapeutic strategy for this
Songling Li   +10 more
wiley   +1 more source

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