Results 11 to 20 of about 95,899 (339)

Demethylases Go Mental [PDF]

Molecular Cell, 2010
Histone-modifying enzymes require recruitment to specific genomic loci in order to elicit their effects. In this issue, Kleine-Kohlbrecher et al. reveal how a histone demethylase is targeted to specific genes, thereby providing mechanistic insight into recruitment and regulation.
Dawson, Mark A., Bannister, Andrew J.
openaire   +2 more sources

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential

Journal of Hematology & Oncology, 2022
RNA demethylase ALKBH5 takes part in the modulation of N 6 -methyladenosine (m 6 A) modification and controls various cell processes. ALKBH5-mediated m 6 A demethylation regulates gene expression by affecting multiple events in RNA metabolism, e.g., pre ...
Jianwei Qu, Haimeng Yan, Yifan Hou, Wen Cao, Yang Liu, E. Zhang, Jingsong He, Z. Cai   +7 more
semanticscholar   +1 more source

FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms

International Journal of Molecular Sciences, 2022
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most abundant mRNA internal modification, which modulates several cellular processes including ...
S. Azzam, Habiba S. Alsafar, Abdulrahim A. Sajini   +2 more
semanticscholar   +1 more source

Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

Molecular Cancer, 2022
Background Gastric cancer (GC) is one of the most pernicious tumors that seriously harm human healthcare. GC metastasis is one of the prime cause of failed cancer treatment, but correlation between N6-methyladenosine (m6A) and GC metastasis was less ...
Yiyang Hu, Chunli Gong, Zhibin Li, Jiao Liu, Yang Chen, Yu Huang, Q. Luo, Sumin Wang, Y. Hou, Shiming Yang, Yufeng Xiao   +10 more
semanticscholar   +1 more source

Fear Stress During Pregnancy Affects Placental m6A-Modifying Enzyme Expression and Epigenetic Modification Levels

Frontiers in Genetics, 2022
As the hub connecting mother and offspring, the placenta’s normal development is vital for fetal growth. Fear stress can cause some structural alterations in the placenta and affect placental development and function. N6-methyladenosine (m6A) is the most
Qiyang Wang, Mingmin Pan, Tong Zhang, Yu Jiang, Peiyuan Zhao, Xihong Liu, Anqi Gao, Liping Yang, Junlin Hou   +8 more
doaj   +1 more source

The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma

Molecular Cancer, 2022
N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) remains elusive. In this study, the expression of
Shufang Jin, Mingyu Li, Hanyue Chang, Ruijie Wang, Zhiyuan Zhang, Jianjun Zhang, Yue He, Hailong Ma   +7 more
semanticscholar   +1 more source

Expressions of m6A methyltransferases and their associations with microR-21 and transforming growth factor-β1 in kidney of rats exposed to cadmium

环境与职业医学, 2022
BackgroundEnvironmental pollutants can affect N6-methyladenosine (m6A) level in the body, but the change of m6A level in kidney after being exposed to cadmium (Cd) and the molecular mechanism of renal injury need to be further studied.
Qian YANG, Yifan ZHANG, Zhichao HAN, Rujie LIU, Yuxing LI, Weitong SHEN, Yufen LIANG, Jiachen ZHANG, Shuangjing LI, Han ZHOU, Lijian LEI   +10 more
doaj   +1 more source

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

Journal of Experimental Medicine, 2021
Abdominal aortic aneurysms (AAAs) are a life-threatening disease characterized by macrophage infiltration contributing to pathological vascular remodeling.
Frank M. Davis, L. Tsoi, W. Melvin, A. denDekker, R. Wasikowski, Amrita D. Joshi, S. Wolf, A. Obi, A. Billi, X. Xing, C. Audu, B. Moore, S. Kunkel, A. Daugherty, Hong S. Lu, J. Gudjonsson, Katherine A. Gallagher   +16 more
semanticscholar   +1 more source

Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus

Frontiers in Plant Science, 2022
The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao, Qi Guo, Sen Cao, Yanting Tian, Kunjin Han, Yuhan Sun, Juan Li, Qingshan Yang, Qingju Ji, Ronald Sederoff, Yun Li   +10 more
doaj   +1 more source

Identification and gene expression analysis of cytosine-5 DNA methyltransferase and demethylase genes in Amaranthus cruentus L. under heavy metal stress

Frontiers in Plant Science, 2023
Amaranth has become increasingly popular due to its highly nutritious grains and ability to tolerate environmental stress. The mechanism underlying defense and adaptation to environmental stress is a complicated process involving DNA methylation and ...
Veronika Lancíková, Jana Kačírová, Andrea Hricová   +2 more
doaj   +1 more source