Results 11 to 20 of about 98,772 (389)
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]
Nature Communications, 2019 Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Seungwon Yang, Jiangbo Wei, Yan-Hong Cui
exaly +4 more sources
Nucleic Acids Research, 2021 Faithful genome integrity maintenance plays an essential role in cell survival. Here, we identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA damage and apoptosis during reactive oxygen species (ROS)-induced stress. We find
Fang Yu, Jiangbo Wei, Xiao-Long Cui
exaly +2 more sources
Nature Communications, 2021 Here we show that FTO as an N6-methyladenosine (m6A) RNA demethylase is degraded by selective autophagy, which is impaired by low-level arsenic exposure to promote tumorigenesis. We found that in arsenic-associated human skin lesions, FTO is upregulated,
Yan-Hong Cui, Seungwon Yang, Jiangbo Wei
exaly +2 more sources
Nature Communications, 2020 Autophagy is essential for cellular survival and energy homeostasis under nutrient deprivation. Despite the emerging importance of nuclear events in autophagy regulation, epigenetic control of autophagy gene transcription remains unclear. Here, we report
Sangwon Byun, Young-Chae Kim, Yang Zhang
exaly +2 more sources
Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure [PDF]
EpigeneticsHistone H4K20 methylation is critical in regulating the cell cycle, DNA damage response, and gene repression in proliferating cells. However, its role in the heart remains poorly understood.
Samuel Hickenlooper +12 more
doaj +2 more sources
Frontiers in Genetics, 2018 Post-translational modification of histones, such as histone methylation controlled by specific methyltransferases and demethylases, play critical roles in modulating chromatin dynamics and transcription in eukaryotes.
Yani Zheng +9 more
doaj +2 more sources
Cell Research, 2019 Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing ...
Junzhong Liu, Qun Li, Muyang Wang
exaly +2 more sources
Nucleic Acids Research, 2017 N6-methyladenosine (m6A) is the most abundant base modification found in messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase established the concept of reversible RNA modification. Here, we present a comprehensive transcriptome-
Marek Bartosovic +2 more
exaly +2 more sources
Histone demethylase KDM5D upregulation drives sex differences in colon cancer
Nature, 2023 Jiexi Li, Kyle A Labella, Chang-Jiun Wu
exaly +2 more sources
Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5 [PDF]
Epigenetics & ChromatinBackground Lysine demethylase 5 (KDM5) family proteins are transcriptional regulators best known for demethylating the promoter-proximal histone mark H3K4me3.
Matanel Yheskel +2 more
doaj +2 more sources