Genome-wide identification and characterization of ALKB homolog gene family in wheat (Triticum aestivum L.) [PDF]
Frontiers in Plant ScienceIntroductionN6-methyladenosine (m6A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. AlkB homologs (ALKBHs) are involved in plant responses to stress by modulating m6A methylation.
Pengkun Wang +6 more
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m6A demethylase CpALKBH regulates CpZap1 mRNA stability to modulate the development and virulence of chestnut blight fungus [PDF]
mBioAs the most abundant eukaryotic mRNA modification, N6-methyladenosine (m6A) plays a crucial role in regulating multiple biological processes. This methylation is regulated by methyltransferases and demethylases.
Lijiu Zhao +4 more
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Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformation yield [PDF]
Journal of Biological EngineeringThe cultivation of opium poppy is the only commercially viable source of most morphinan alkaloids. Bioproduction of morphinan alkaloids in recombinant whole-cell systems provides a promising alternate source of these valuable compounds.
Garrick W. K. Spencer +5 more
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Structural requirements for substrate recognition of Mycobacterium tuberculosis 14α-demethylase: implications for sterol biosynthesis [PDF]
Journal of Lipid Research, 2001 Sterol 14α-demethylase (14DM) is a cytochrome P-450 involved in sterol biosynthesis in eukaryotes. It was reported that Mycobacterium smegmatis also makes cholesterol and that cholesterol is essential to Mycobacterium tuberculosis (MT) infection ...
Aouatef Bellamine +4 more
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Journal of Fungi, 2021 The epigenetic modifications control the pathogenicity of human pathogenic fungi, which have been poorly studied in Mucorales, causative agents of mucormycosis.
Macario Osorio-Concepción +4 more
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The Roles and Regulation of m6A Modification in Glioblastoma Stem Cells and Tumorigenesis
Biomedicines, 2022 Glioblastoma is the most common and most lethal primary malignant brain tumor. N6-methyladenosine (m6A) is a widespread and abundant internal messenger RNA (mRNA) modification found in eukaryotes.
Peng Li +4 more
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Frontiers in Plant Science, 2023 Amaranth has become increasingly popular due to its highly nutritious grains and ability to tolerate environmental stress. The mechanism underlying defense and adaptation to environmental stress is a complicated process involving DNA methylation and ...
Veronika Lancíková +2 more
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The role of demethylase AlkB homologs in cancer
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
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Editorial: The emerging role of protein methylation/demethylation modification in disease and homeostasis [PDF]
Frontiers in Molecular BiosciencesYan-Jun Liu +3 more
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eLife, 2020 H3K9 methylation (H3K9me) specifies the establishment and maintenance of transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone modifications is widely assumed to be the primary mechanism that reverses epigenetic ...
Gulzhan Raiymbek +8 more
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