Results 11 to 20 of about 98,623 (241)

Effects of Cyclamen trochopteranthum on hepatic drug-metabolizing enzymes [PDF]

Archives of Biological Sciences, 2011
The modulatory effects of the Cyclamen trochopterantum tuber extract on hepatic drug-metabolizing enzymes, including aniline 4-hydroxylase (A4H; CYP2E1), ethoxyresorufin O-deethylase (EROD; CYP1A), methoxyresorufin O-demethylase (MROD; CYP1A ...
Arslan Sevki, Ozgun Ozden, Celik Gurbet, Semiz Asli, Dusen Olcay, Mammadov Ramazan, Sen Alaattin   +6 more
doaj   +4 more sources

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

Cancer Cell, 2017
Hengyou Weng, Rui Su, Xiaocheng Weng
exaly   +2 more sources

Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1 [PDF]

, 2007
In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two
Abdelhalim Boukaba, Antony M. Carr, BG Mellone, C Martin, Carolina Bonilla, D Robyr, David Lando, E Metzger, E Nicolas, Ernest D. Laue, G Rigaut, GW Humphrey, I Sinha, IM Hall, J Bahler, J Nakayama, James Cauwood, JF Flanagan, JJ Tasto, Juan Valcarcel, Julian Walfridsson, K Noma, K Yamane, Karl Ekwall, M Wiren, MA Hakimi, MG Lee, MG Lee, Michael Opel, MJ Buck, Natalia V. Murzina, P Bjerling, PA Cloos, Petra J.H. Werler, PJ Werler, R Schneider, RJ Klose, RJ Sims 3rd, Robin C. Allshire, Sarah C. Trewick, SI Grewal, SK Kurdistani, Tony Kouzarides, U Kleeberg, Y Shi, Y Shi, Y Tsukada, Y Xue, YJ Shi   +48 more
core   +14 more sources

Downregulation of the FTO m6A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors

Nature Cancer, 2021
Evelyne Collignon, Clémence Al Wardi, Mohammad Krayem   +2 more
exaly   +2 more sources

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2022
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang, Runjiao Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Fangzhen Guo, Fangzhen Guo, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +12 more
doaj   +1 more source

Gene Expression Profiles of Methyltransferases and Demethylases Associated with Metastasis, Tumor Invasion, CpG73 Methylation, and HPV Status in Head and Neck Squamous Cell Carcinoma

Current Issues in Molecular Biology, 2023
Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan, Tomaž Büdefeld, Helena Čelešnik, Matija Švagan, Boštjan Lanišnik, Uroš Potočnik   +5 more
doaj   +1 more source

Dynamics of H3K27me3 Modification on Plant Adaptation to Environmental Cues

Plants, 2021
Given their sessile nature, plants have evolved sophisticated regulatory networks to confer developmental plasticity for adaptation to fluctuating environments.
Qingwen Shen, Yisheng Lin, Yingbo Li, Guifeng Wang   +3 more
doaj   +1 more source

Effects of aluminum on expressions of fat mass and obesity-associated protein and brain-derived neurotrophic factor in rat brain and PC12 cells

环境与职业医学, 2022
BackgroundChemical modification of RNA is a recent hotspot in the field of epigenetics, but the specific mechanism of chemical modification of RNA in aluminum neurotoxicity has not been fully reported.ObjectiveTo investigate the alterations of fat mass ...
Mengtong XU, Tiantian WANG, Wenjing LI, Chunman YUAN, Jing SONG   +4 more
doaj   +1 more source

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential

Journal of Hematology & Oncology, 2022
RNA demethylase ALKBH5 takes part in the modulation of N 6 -methyladenosine (m 6 A) modification and controls various cell processes. ALKBH5-mediated m 6 A demethylation regulates gene expression by affecting multiple events in RNA metabolism, e.g., pre ...
Jianwei Qu, Haimeng Yan, Yifan Hou, Wen Cao, Yang Liu, E. Zhang, Jingsong He, Z. Cai   +7 more
semanticscholar   +1 more source

The Latest Research Progress of m6A Modification and Its Writers, Erasers, Readers in Infertility: A Review

Frontiers in Cell and Developmental Biology, 2021
Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N6-methyladenosine (m6A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by ...
Xuda Liu, Haiying Wang, Bingchen Liu, Zhipeng Qi, Jiashuo Li, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng   +8 more
doaj   +1 more source