Results 11 to 20 of about 36,880 (185)

The Latest Research Progress of m6A Modification and Its Writers, Erasers, Readers in Infertility: A Review

Frontiers in Cell and Developmental Biology, 2021
Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N6-methyladenosine (m6A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by ...
Xuda Liu, Haiying Wang, Bingchen Liu, Zhipeng Qi, Jiashuo Li, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng   +8 more
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Effects of aluminum on expressions of fat mass and obesity-associated protein and brain-derived neurotrophic factor in rat brain and PC12 cells

环境与职业医学, 2022
BackgroundChemical modification of RNA is a recent hotspot in the field of epigenetics, but the specific mechanism of chemical modification of RNA in aluminum neurotoxicity has not been fully reported.ObjectiveTo investigate the alterations of fat mass ...
Mengtong XU, Tiantian WANG, Wenjing LI, Chunman YUAN, Jing SONG   +4 more
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The Discovery of Histone Demethylases [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yuichi-I. Tsukada, Yujiang Geno Shi
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Demethylases Go Mental [PDF]

Molecular Cell, 2010
Histone-modifying enzymes require recruitment to specific genomic loci in order to elicit their effects. In this issue, Kleine-Kohlbrecher et al. reveal how a histone demethylase is targeted to specific genes, thereby providing mechanistic insight into recruitment and regulation.
Mark A. Dawson, Mark A. Dawson, Andrew J. Bannister   +2 more
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Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus

Frontiers in Plant Science, 2022
The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao, Qi Guo, Sen Cao, Yanting Tian, Kunjin Han, Yuhan Sun, Juan Li, Qingshan Yang, Qingju Ji, Ronald Sederoff, Yun Li   +10 more
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Expressions of m6A methyltransferases and their associations with microR-21 and transforming growth factor-β1 in kidney of rats exposed to cadmium

环境与职业医学, 2022
BackgroundEnvironmental pollutants can affect N6-methyladenosine (m6A) level in the body, but the change of m6A level in kidney after being exposed to cadmium (Cd) and the molecular mechanism of renal injury need to be further studied.
Qian YANG, Yifan ZHANG, Zhichao HAN, Rujie LIU, Yuxing LI, Weitong SHEN, Yufen LIANG, Jiachen ZHANG, Shuangjing LI, Han ZHOU, Lijian LEI   +10 more
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Fear Stress During Pregnancy Affects Placental m6A-Modifying Enzyme Expression and Epigenetic Modification Levels

Frontiers in Genetics, 2022
As the hub connecting mother and offspring, the placenta’s normal development is vital for fetal growth. Fear stress can cause some structural alterations in the placenta and affect placental development and function. N6-methyladenosine (m6A) is the most
Qiyang Wang, Mingmin Pan, Tong Zhang, Yu Jiang, Peiyuan Zhao, Xihong Liu, Anqi Gao, Liping Yang, Junlin Hou   +8 more
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Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

Frontiers in Neuroscience, 2020
Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han, Zhen Liu, Yingying Xu, Xiangtian Liu, Dewei Wang, Fan Li, Yun Wang, Jianzhong Bi   +7 more
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Biological and therapeutic role of LSD1 in Alzheimer’s diseases

Frontiers in Pharmacology, 2022
Alzheimer’s disease (AD) is a common chronic neurodegenerative disease characterized by cognitive learning and memory impairments, however, current treatments only provide symptomatic relief.
Yu Li, Yuanyuan Zhao, Xiaona Li, Liuqun Zhai, Hua Zheng, Ying Yan, Qiang Fu, Jinlian Ma, Haier Fu, Zhenqiang Zhang, Zhonghua Li   +10 more
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DNA Methylation on N6-Adenine Regulates the Hyphal Development during Dimorphism in the Early-Diverging Fungus Mucor lusitanicus

Journal of Fungi, 2021
The epigenetic modifications control the pathogenicity of human pathogenic fungi, which have been poorly studied in Mucorales, causative agents of mucormycosis.
Macario Osorio-Concepción, Carlos Lax, Eusebio Navarro, Francisco E. Nicolás, Victoriano Garre   +4 more
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