Results 201 to 210 of about 98,772 (389)

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer Cell, 2019
Yue Huang, R. Su, Yue Sheng, Lei Dong, Ze Dong, Hongjiao Xu, Tengfeng Ni, Zijie Zhang, Tao Zhang, Chenying Li, Li Han, Zhenyun Zhu, F. Lian, Jiangbo W, Qiang-qiang Deng, Yungui Wang, M. Wunderlich, Zhi-wei Gao, Guoyu Pan, D. Zhong, Hu Zhou, Naixia Zhang, J. Gan, Hualiang Jiang, J. Mulloy, Zhijian Qian, Jianjun Chen, Cai-Guang Yang   +27 more
semanticscholar   +1 more source

Rosuvastatin Upregulates RCOR1 to Repress C10ORF10 Transcription and Alleviate Oxidative Stress and Plaque Formation in Atherosclerosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rosuvastatin (RVS) is an HMG‐CoA reductase inhibitor with lipid‐lowering properties. This study aims to investigate the role of RVS in plaque formation in atherosclerosis (AS) and its functional mechanism. ApoE−/− mice were fed a high‐fat diet to generate a mouse model of AS.
Xin Fu, Chuang Liu, Ya‐Li Chen, Jie‐Lin Qin, Ting‐Ting Wang, Shan‐Shan Fu   +5 more
wiley   +1 more source

Cutting Edge: Hypoxia Sensing by the Histone Demethylase UTX (KDM6A) Limits Colitogenic CD4+ T Cells in Mucosal Inflammation [PDF]

Mandy I. Cheng, Lee K. Hong, Christian Bustillos, Bryan Chen, Scott Chin, Christopher R. Luthers, Au Vo, Shehzad Z. Sheikh, Maureen A. Su   +8 more
openalex   +1 more source

The Jumonji-C Histone Lysine Demethylase KDM3B Senses Cellular Iron to Regulate Anabolism Through mTORC1

, 2021
Jason Shapiro, Hsiang‐Chun Chang, Zibo Zhao, Justin Geier, Elizabeth T. Bartom, Chunlei Chen, Yihan Chen, Adam De Jesus, Zohra Sattar, Farnaz Keyhani‐Nejad, Tatsuya Sato, Lucía Ramos-Alonso, Antonia María Romero, María Teresa Martínez‐Pastor, Shang-chuan Jiang, Shiv K. Sah‐Teli, Liming Li, David J. Bentrem, Gary D. Lopaschuk, Issam Ben‐Sahra, Thomas V. O’Halloran, Ali Shilatifard, Sergi Puig, Joy Bergelson, Peppi Koivunen, Hossein Ardehali   +25 more
openalex   +1 more source

Involvement of the miR‐128‐3p/KDM3A/NLRP3 Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen, Jian‐Bo Feng, Yin‐Sheng Cai, Nan Lin, Fei Lv, Zhu‐Sheng Guo   +5 more
wiley   +1 more source

Point mutations in the squalene epoxidase erg1 and sterol 14‐α demethylase erg11 gene of T indotineae isolates indicate that the resistant mutant strains evolved independently [PDF]

, 2021
Anke Burmester, Uta‐Christina Hipler, Peter Elsner, Cornelia Wiegand   +3 more
openalex   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

The Saccharomyces cerevisiae Histone Demethylase Jhd1 Fine-Tunes the Distribution of H3K36me2

, 2020
Jincun Fang, G. J. Hogan, Ge-Hao Liang, J. D. Lieb, Y. Zhang   +4 more
openalex   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

Active site topology of Saccharomyces cerevisiae lanosterol 14 alpha-demethylase (CYP51) and its G310D mutant (cytochrome P-450SG1).

, 1992
Stephen F. Tuck, Yuri Aoyama, Yuzo Yoshida, P.R. Ortiz de Montellano   +3 more
openalex   +1 more source