Results 211 to 220 of about 47,850 (262)

Mapping the RNA methylome under drought: techniques, mechanisms, and agricultural implications. [PDF]

Front Plant Sci
Fan X, Zhang Y.
europepmc   +1 more source

KDM2B controls HIF levels and activity through its JmjC and CxxC domains

Batie M, Shakir D, Kwok C, Bell G, Kou J, Bakhsh A, Rocha S.   +6 more
europepmc   +1 more source

Alkbh5a-mediated m6A methylation promotes seawater adaptation via chromatin remodeling and tonebpa1 activation in anadromous Oncorhynchus mykiss

Tian Y, Yu H, Sun Y, Gundappa MK, Lu Y, Zeng X, Wang B, He J, Zhu H, Li D, Qu Y, Xin C, Yu Y, Meng X, Macqueen D, Gao Q.   +15 more
europepmc   +1 more source

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When Is a Demethylase Not a Demethylase?

Science Signaling, 2011
The histone lysine demethylase JARID1a has demethylase-independent function in the circadian clock.
openaire   +2 more sources

Inhibitors of histone demethylases

Bioorganic & Medicinal Chemistry, 2011
Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.
Lohse, Brian, Kristensen, Jesper L, Kristensen, Line H, Agger, Karl, Helin, Kristian, Gajhede, Michael, Clausen, Rasmus P   +6 more
openaire   +3 more sources

AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function [PDF]

Cell Research, 2010
LSD1 (KDM1 under the new nomenclature) was the first identified lysine-specific histone demethylase belonging to the flavin-dependent amine oxidase family. Here, we report that AOF1 (KDM1B under the new nomenclature), a mammalian protein related to LSD1, also possesses histone demethylase activity with specificity for H3K4me1 and H3K4me2.
, M David Stewart, Jiemin Wong
exaly   +3 more sources

Lysine demethylases and cancer

Pathology - Research and Practice
Epigenetic mechanisms are of pivotal importance in the normal development and maintenance of cell and tissue-specific gene expression patterns, and are fundamental to the genesis of cancer. One significant category of epigenetic modifications is histone methylation.
Tomas, Eckschlager, Ales, Vicha, Daniela, Frolikova   +2 more
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In Vitro Histone Demethylase Assays

2009
Histone methylation plays important roles in chromatin structure, transcription, and epigenetic state of the cell. Tremendous discoveries recently demonstrated that methylation mark is not static but is dynamically regulated by both histone methyltransferases and the histone demethylases.
Kenji, Kokura, Jia, Fang
openaire   +2 more sources

Histone demethylases in development and disease

Trends in Cell Biology, 2010
Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a
Pedersen, Marianne Terndrup, Helin, Kristian   +1 more
openaire   +3 more sources