Results 201 to 210 of about 47,850 (262)

Metabolic Profiling of Epigenetic Aging and Its Associations With Aging‐Related Phenotypes and Modifiable Lifestyle Factors

Aging Cell, Volume 25, Issue 9, September 2026.
This study provides novel insights into the metabolic correlates of epigenetic aging biomarkers and underscores the potential of metabolomics‐informed metrics of epigenetic aging as informative indicators of physiological decline and lifestyle effects.
Xunying Zhao, Tianpei Ma, Maoyao Xia, Xinyang Dui, Yangdan Zhong, Xin Chen, Yang Qu, Bowen Lei, Qingwen Zhao, Xueyao Wu, Haiyu Yan, Xingyu Zhang, Ke Jiang, Lin Hu, Lu Long, Mengyu Fan, Jiaqiang Liao, Tao Zhang, Xia Jiang, Jiayuan Li, Ben Zhang   +20 more
wiley   +1 more source

Lysine demethylases 6 A and 6B as epigenetic regulators in therapeutic resistance of cancer. [PDF]

Clin Epigenetics
Yang L, Li H, Zhao Y, Qian Z, Luo G, Chen X, Yang X.   +6 more
europepmc   +1 more source

Oxygenaging: A Physiological Framework for Geroscience

Aging Cell, Volume 25, Issue 9, September 2026.
Mechanisms of aging disrupt oxygen homeostasis through three converging processes: oxygen‐cascade impairment, microvascular dysfunction, and molecular maladaptation. “Oxygenaging” integrates these domains to explain how declining oxygen delivery and utilization drive mitochondrial instability and amplify the effect of the hallmarks of aging.
Stefano Donega, Kenneth W. Fishbein, Paolo Dominelli, Allison B. Herman, Rafael de Cabo, Myriam Gorospe, Luigi Ferrucci   +6 more
wiley   +1 more source

Metabolic oxidoreductases: central regulators of the epigenetic landscapes in stemness. [PDF]

Exp Mol Med
Lee HT, Roe JS, Youn HD.
europepmc   +1 more source

Comprehensive Quantification of Oligoasthenozoospermia Induced by Obesity, Reproductive Toxicants, and Their Combination in Rat Models

Andrology, Volume 14, Issue 6, Page 1535-1551, September 2026.
ABSTRACT Background Oligoasthenozoospermia is a leading cause of male infertility and has been increasingly associated with the global surge in obesity and exposure to reproductive toxicants. Despite extensive research on each factor individually, their combined pathological effects remain poorly understood.
Yunlong Yao, Xi Zhang, Lingru Li, Yunzhi Zhang, Shuo Huang, Yulin Zong, Mingrui Li, Fufangyu Zhao, Linghui Zhu, Tianxing Li, Wenlong Sun, Mingyan Shao, Yanfei Zheng   +12 more
wiley   +1 more source

Rare KDM4C variants and reduced expression underlie epigenetic dysregulation in rheumatoid arthritis. [PDF]

Immunol Res
Oner DA, Toktas H, Dundar U, Adar S, Eyvaz N.   +4 more
europepmc   +1 more source

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients

Clinical Genetics, Volume 110, Issue 3, Page 379-388, September 2026.
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Camille Bergès, Clément Sauvestre, Sophie Naudion, Catherine Vincent Delorme, Thomas Smol, Mélanie Rama, Stephanie Moortgat, Isabelle Maystadt, Rogier Kersseboom, Martina Wilke, Tahsin Stefan Barakat, Yoann Vial, Laurence Perrin, Sandrine Passemard, Farooq Ahmad, Muhammad Umair, Tobias Haack, Mona Grimmel, Alma Kuechler, Anne Slavotinek, Patrick Devine, Ugur Hodoglugil, Faisal Zafar, Erum Afzal, Tracy Dudding‐Byth, Guillaume Jouret, Lucas Herissant, Stephanie Efthymiou, Henry Houlden, Marine Legendre, Vincent Michaud   +30 more
wiley   +1 more source

Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming. [PDF]

JCI Insight
Wanner N, Keller J, Liaukouskaya N, Andrieux G, Laufer SD, Rogg M, Bork T, Liang W, Braun F, Haas F, Wong MN, Puelles VG, Gies SE, Meyer C, Boerries M, Helmstädter M, Kretz O, Hild I, Metzger E, Schüle R, Bechtel-Walz W, Huber TB.   +21 more
europepmc   +1 more source

Histone modification cross-talk: analytical tools and molecular mechanisms. [PDF]

Biochem J
Jiang J, DuBois-Coyne S, Nam E, Whedon SD, Lee K, Cole PA.   +5 more
europepmc   +1 more source

HBx-mediated GPT2 suppression promotes liver cancer development by downregulating ADH1A. [PDF]

Cancer Biol Med
You H, Wang X, Liu R, Wang Y, Zhang H, Ma L, Bao E, Zhong Y, Liu X, Kong D, Pan X, Li X, Qin S, Zheng K, Li C, Tang R, Kong F.   +16 more
europepmc   +1 more source