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The emerging functions of histone demethylases
Current Opinion in Genetics & Development, 2008Epigenetic information refers to heritable changes in gene function that are stable between cell divisions but which is not a result of changes in the DNA sequence. Part of the epigenetic mechanism has been ascribed to modifications of histones or DNA that affects the transcription of specific genes. In this context, post-translational modifications of
Agger, Karl +3 more
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Histone methylation is a dynamic process that contributes to the control of gene expression by influencing chromatin structure. Since their initial discovery 20 years ago, histone demethylases have been shown to play a critical role in histone methylation and thus developmental, physiological, and pathological processes.
Stephen C. Kales, Anton Simeonov
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Stephen C. Kales, Anton Simeonov
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JMJD6 Is a Histone Arginine Demethylase
Science, 2007Arginine methylation occurs on a number of proteins involved in a variety of cellular functions. Histone tails are known to be mono- and dimethylated on multiple arginine residues where they influence chromatin remodeling and gene expression. To date, no enzyme has been shown to reverse these regulatory modifications.
Bingsheng, Chang +3 more
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In Vitro Histone Demethylase Assays
2022Dynamic histone methylation regulates gene activation and repression. It is involved in proliferation, differentiation, lineage specification, and development. Histone demethylase assays are invaluable in studying histone demethylation substrate recognition, kinetics, regulation, and inhibition by small molecules, many of which are potential ...
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In Vitro Histone Demethylase Assays
2015Histone methylation plays pivotal roles in modulating chromatin structure and dynamics and in turn regulates genomic processes that require access to the DNA template. The methylation status at different sites is dynamically regulated by histone methyltransferases and demethylases. During the past decade, two classes of proteins have been characterized
Kenji, Kokura, Lidong, Sun, Jia, Fang
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Assay and Analysis of Dimethylsulfoniopropionate Demethylase
2018Dimethylsulfoniopropionate (DMSP) demethylase is a tetrahydrofolate-dependent enzyme that initiates the DMSP demethylation pathway in marine bacteria. This enzyme is important for understanding of organic sulfur flux from the oceans because it directs the sulfur from DMSP away from dimethylsulfide.
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Lysine Demethylases Inhibitors
Journal of Medicinal Chemistry, 2011Takayoshi, Suzuki, Naoki, Miyata
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Interfering with histone demethylases in HSCs
Blood, 2013In this issue of Blood , Cellot et al identify the histone demethylase Jarid1b as a key regulator of renewal and differentiation in hematopoietic stem cells (HSCs).[1][1] ![Figure][2] Proposed model for JARID1B activity in HSC regulation.
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Profiling demethylase activity using epigenetically inactivated DNAzyme
Biosensors and Bioelectronics, 2022Zhenkun Wu +2 more
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