Results 31 to 40 of about 36,880 (185)
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition [PDF]
, 2014 CYP51 (sterol 14α-demethylase) is an efficient target for clinical and agricultural antifungals and an emerging target for treatment of Chagas disease, the infection that is caused by multiple strains of a protozoan pathogen Trypanosoma cruzi.
Cherkesova, Tatiana S. +6 more
core +1 more source
The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain [PDF]
, 2020 Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in
Biasutto, Antonio J +4 more
core +1 more source
Histone Demethylases in Colon Cancer [PDF]
Current Colorectal Cancer Reports, 2014 Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Joaquina Baranda +5 more
openaire +2 more sources
Frontiers in Genetics, 2018 Post-translational modification of histones, such as histone methylation controlled by specific methyltransferases and demethylases, play critical roles in modulating chromatin dynamics and transcription in eukaryotes.
Yani Zheng +9 more
doaj +1 more source
Balkan Medical Journal, 2022 Background: Diffuse large B-cell lymphoma is a type of B-cell non-Hodgkin lymphoma with a high incidence. About one-third of patients are resistant or eventually relapse.
YuYing Cui +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most diagnosed cancer worldwide since 2020. Histone methylation is a common biological epigenetic modification mediating varieties of physiological and pathological ...
Guan-Jun Yang +18 more
doaj +1 more source
Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy. [PDF]
, 2017 Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease.
Cucchiara, Vito +5 more
core +2 more sources
Histone Demethylases in Cancer [PDF]
Current Pharmacology Reports, 2015 Epigenetic regulation, which involves with covalent modifications of DNA and the protein that bundles DNA, namely histones, is an exciting and variable phenomenon that affects normal cellular genetic character and contributes to human diseases. One key histone modification is methylation, regulated by methyl transferases and demethylases.
Santanu Paul +5 more
openaire +2 more sources
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
Nature Communications, 2021 The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier +21 more
doaj +1 more source
Progress in research on m6A modification of FTO mediated-RNA and development [PDF]
Jichu yixue yu linchuang, 2022 Human fat mass and obesity associated protein FTO is the first confirmed N6-methyladenosine(m6A) demethylase, which demonstrated the existence of reversible RNA modification, and also unveiled the prelude of m6A modification research.
PAN Ming-min, WANG Qi-yang, YANG Li-ping
doaj +1 more source