Results 71 to 80 of about 95,899 (339)

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target [PDF]

, 2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy.
Abate F., Agostinelli C., Amente S., Berti E., Bertolini F., Brundu F., Cerroni L., Dellino G. I., Etebari M., Facchetti F., Falini B., Fuligni F., Indio V., Laginestra M. A., Melle F., Motta G., Orecchioni S., Paulli M., Piccioni R., Pileri A., Pileri S. A., Pimpinelli N., Rabadan R., Rossi M., Sabattini E., Sapienza M. R., Tabanelli V., Talarico G., Tarantino G., Tripodo C., Truni M.   +30 more
core   +2 more sources

Histone demethylase SlJMJ6 promotes fruit ripening by removing H3K27 methylation of ripening-related genes in tomato.

New Phytologist, 2020
Fruit ripening is governed by a complex regulatory network. Reversible histone methylation and demethylation regulate chromatin structure and gene expression.
Zhiwei Li, Guoxiang Jiang, Xuncheng Liu, Xiaochun Ding, Dandan Zhang, Xiaowan Wang, Yijie Zhou, Huiling Yan, Taotao Li, Keqiang Wu, Yue-ming Jiang, X. Duan   +11 more
semanticscholar   +1 more source

Hitting histone demethylases [PDF]

Science-Business eXchange, 2012
A GSK–Structural Genomics Consortium team has identified the first potent and selective histone demethylase inhibitor and shown that the molecule dampens the macrophage inflammatory response. The pharma now is focusing on internal efforts and external approaches to exploring potential therapeutic applications of the inhibitor.
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Genome-wide identification and characterization of ALKB homolog gene family in wheat (Triticum aestivum L.)

Frontiers in Plant Science
IntroductionN6-methyladenosine (m6A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. AlkB homologs (ALKBHs) are involved in plant responses to stress by modulating m6A methylation.
Pengkun Wang, Tianye Zhang, Zechi Wu, Lei Yu, Pingan Liao, Jian Yang, Bingjian Sun   +6 more
doaj   +1 more source

Genome-wide identification and expression analysis of DNA demethylase family in cotton

Journal of Cotton Research, 2019
Background DNA methylation is an important epigenetic factor that maintains and regulates gene expression. The mode and level of DNA methylation depend on the roles of DNA methyltransferase and demethylase, while DNA demethylase plays a key role in the ...
Xiaomin YANG, Xuke LU, Xiugui CHEN, Delong WANG, Junjuan WANG, Shuai WANG, Lixue GUO, Chao CHEN, Xiaoge WANG, Xinlei WANG, Wuwei YE   +10 more
doaj   +1 more source

Targeting epigenetic regulators to overcome drug resistance in cancers

Signal Transduction and Targeted Therapy, 2023
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
doaj   +1 more source

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. [PDF]

, 2016
KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that
Feng, X, Guan, K-L, Han, X-R, Lei, Q-Y, Xia, Y-K, Xiong, Y, Yuan, H-X, Zha, Z   +7 more
core   +3 more sources

Diatoms synthesize sterols by inclusion of animal and fungal genes in the plant pathway [PDF]

, 2020
Diatoms are ubiquitous microalgae that have developed remarkable metabolic plasticity and gene diversification. Here we report the first elucidation of the complete biosynthesis of sterols in the lineage.
, Angela, d’Ippolito, Giuliana, Fontana, Angelo, GALLO, CARMELA, LANDI, SIMONE, MANZO, EMILIANO, Nuzzo, Genoveffa, Sardo &   +7 more
core   +1 more source

RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening

Genome Biology, 2019
Methylation of nucleotides, notably in the forms of 5-methylcytosine (5mC) in DNA and N6-methyladenosine (m6A) in mRNA, carries important information for gene regulation. 5mC has been elucidated to participate in the regulation of fruit ripening, whereas
Leilei Zhou, S. Tian, G. Qin
semanticscholar   +1 more source