Results 71 to 80 of about 98,772 (389)

Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation. [PDF]

PLoS ONE, 2015
The removal of histone H3 trimethylation at lysine residue 27 (H3K27me3) plays a critical role in the transcriptional initiation of developmental genes.
Sung Chul Kang, Se Kye Kim, Jin Choul Chai, Sun Hwa Kim, Kyoung-Jae Won, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai   +7 more
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target [PDF]

, 2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy.
Abate F., Agostinelli C., Amente S., Berti E., Bertolini F., Brundu F., Cerroni L., Dellino G. I., Etebari M., Facchetti F., Falini B., Fuligni F., Indio V., Laginestra M. A., Melle F., Motta G., Orecchioni S., Paulli M., Piccioni R., Pileri A., Pileri S. A., Pimpinelli N., Rabadan R., Rossi M., Sabattini E., Sapienza M. R., Tabanelli V., Talarico G., Tarantino G., Tripodo C., Truni M.   +30 more
core   +2 more sources

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. [PDF]

, 2020
Fatty acid and triglyceride synthesis increases greatly in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of various enzymes in lipogenic pathway, including fatty acid synthase and glycerol-3 ...
Choi, Yoon, Nguyen, Hai, SUL, Hei Sook, Viscarra, Jose, Wang, Yuhui   +4 more
core  

Does litomosoides sigmodontis synthesize dimethylethanolamine from choline? [PDF]

, 2008
Juvenile female Litomosoides sigmodontis secrete a protein (Juv-p120) highly modified with dimethylethanolamine (DMAE). In an attempt to establish the source of this decoration worms were pulsed with [3H]-choline and [3H]-ethanolamine and the radio ...
Allen, J E, Allen, Judith, Babayan, S A, Harnett, W, Houston, K M   +4 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Smoking-induced long-lasting modifications of human platelet serotonin catabolism through a MAO epigenetic regulation [PDF]

, 2008
Postulating that serotonin, secreted from smoking-activated platelets, could be involved in smoking-induced vascular modifications, we studied 115 men distributed in smokers (S), former smokers (FS) and never smokers (NS).
Alain Simon, Francine Rendu, Gilles Chironi, Jacques Callebert, Jacques Mallet, Jean-Louis Mé, Jean-Marie Launay, Katell Peoc', Muriel Del Pino   +8 more
core   +1 more source

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]

, 2016
Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe, Forgione, Mariantonietta, Forneris, Federico, Lucidi, Alessia, Mai, Antonello, Marrocco, Biagina, Mattevi, Andrea, Mehdipour, Parinaz, Pilotto, Simona, Rotili, Dante, Speranzini, Valentina, Velankar, Sameer   +11 more
core   +2 more sources

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase

bioRxiv, 2020
N6-methyladenosine (m6A) is the most common modification on endogenous RNA transcripts in mammalian cells. Currently, the lack of precise single-nucleotide RNA modification tools makes it challenging to understand the relationship between site-specific ...
Zhenfang Xia, Min Tang, Jiayan Ma, Hongyan Zhang, Ryan C. Gimple, B. Prager, Hongzhen Tang, Chongran Sun, Fuyi Liu, Peng Lin, Y. Mei, Ruoxin Du, J. Rich, Qi Xie   +13 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Histone demethylase SlJMJ6 promotes fruit ripening by removing H3K27 methylation of ripening-related genes in tomato.

New Phytologist, 2020
Fruit ripening is governed by a complex regulatory network. Reversible histone methylation and demethylation regulate chromatin structure and gene expression.
Zhiwei Li, Guoxiang Jiang, Xuncheng Liu, Xiaochun Ding, Dandan Zhang, Xiaowan Wang, Yijie Zhou, Huiling Yan, Taotao Li, Keqiang Wu, Yue-ming Jiang, X. Duan   +11 more
semanticscholar   +1 more source