Results 81 to 90 of about 98,772 (389)
Aging, 2021 As a systemic disease, osteoporosis (OP) results in bone density loss and fracture risk, particularly in the hip and vertebrae. However, the underlying molecular mechanisms of OP development have not been fully illustrated.
Jing Wang +8 more
semanticscholar +1 more source
Hitting histone demethylases [PDF]
Science-Business eXchange, 2012 A GSK–Structural Genomics Consortium team has identified the first potent and selective histone demethylase inhibitor and shown that the molecule dampens the macrophage inflammatory response. The pharma now is focusing on internal efforts and external approaches to exploring potential therapeutic applications of the inhibitor.
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Frontiers in Plant ScienceIntroductionN6-methyladenosine (m6A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. AlkB homologs (ALKBHs) are involved in plant responses to stress by modulating m6A methylation.
Pengkun Wang +6 more
doaj +1 more source
Identification and characterization of PKF118-310 as a KDM4A inhibitor
Epigenetics, 2017 Epigenetic modifications are functionally involved in gene expression regulation. In particular, histone posttranslational modifications play a crucial role in functional chromatin organization. Several drugs able to inhibit or stimulate some families of
Gianluigi Franci +3 more
doaj +1 more source
Genome-wide identification and expression analysis of DNA demethylase family in cotton
Journal of Cotton Research, 2019 Background DNA methylation is an important epigenetic factor that maintains and regulates gene expression. The mode and level of DNA methylation depend on the roles of DNA methyltransferase and demethylase, while DNA demethylase plays a key role in the ...
Xiaomin YANG +10 more
doaj +1 more source
Targeting epigenetic regulators to overcome drug resistance in cancers
Signal Transduction and Targeted Therapy, 2023 Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
doaj +1 more source
Synergistic Anti-Candida Activity of Bengazole A in the Presence of Bengamide A †. [PDF]
, 2019 Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and ...
Cheng, Tina +3 more
core
Genome Biology, 2019 Methylation of nucleotides, notably in the forms of 5-methylcytosine (5mC) in DNA and N6-methyladenosine (m6A) in mRNA, carries important information for gene regulation. 5mC has been elucidated to participate in the regulation of fruit ripening, whereas
Leilei Zhou, S. Tian, G. Qin
semanticscholar +1 more source
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.
Molecules and Cells, 2020 LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple cancers.
Sang-Ah Kim +4 more
semanticscholar +1 more source