Results 81 to 90 of about 43,841 (247)

A Phase 1 Randomized Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Escalating Oral Doses of Dordaviprone and the Effects of Food on the Bioavailability of Dordaviprone in Healthy Adult Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dordaviprone (ONC201) is a novel, small molecule imipridone with antitumor effects in glioma patients. This study evaluated the pharmacokinetics and safety of dordaviprone following single escalating doses (Part A), as a capsule content mixed with applesauce or Gatorade (sports drink) [Part B1]), and with or without food [Part B2].
Shamia L. Faison, Joelle Batonga, Thangam Arumugham, Angela Bartkus, Marion Morrison, Mark J. Mullin, Tim Tippin, Odin Naderer   +7 more
wiley   +1 more source

The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5794-5806, December 2022., 2022
Abstract Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucleotide polymorphisms (SNPs) and BC. This study
Saeid Doaei, Sepideh Abdollahi, Golsa Khalatbari Mohseni, Maryam Gholamalizadeh, Mohammad Esmail Akbari, Seyed Mohammad Poorhosseini, Seyedeh Elaheh Bagheri, Soudeh Ghafouri‐Fard, Ghasem Azizi Tabesh, Alireza Moslem, Naeemeh Hasanpour Ardekanizadeh, Saeed Omidi, Azita Hekmatdoost, Mahdi Alam Rajabi, Seyed Alireza Mosavi Jarrahi, Mark O. Goodarzi   +15 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

The RNA N6‐methyladenosine demethylase ALKBH9B modulates ABA responses in Arabidopsis

Journal of Integrative Plant Biology, Volume 64, Issue 12, Page 2361-2373, December 2022., 2022
The RNA m6A demethylase ALKBH9B removes m6A from the ABSCISIC ACID (ABA) INSENSITIVE 1 (ABI1) and BRI1‐EMS‐SUPPRESSOR 1 (BES1) transcripts, thus stabilizing them and leading to the inhibition of ABI3 and ABI5 by ABI1 and BES1 proteins, promoting seed germination and early seedling development under ABA treatment.
Jun Tang, Junbo Yang, Qiang Lu, Qian Tang, Shuyan Chen, Guifang Jia   +5 more
wiley   +1 more source

The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis

Memorias do Instituto Oswaldo Cruz, 2012
Ketoconazole is a clinically safe antifungal agent that also inhibits the growth of Leishmania spp. A study was undertaken to determine whether Leishmania parasites are prone to becoming resistant to ketoconazole by upregulating C14-demethylase after ...
Valter Viana Andrade-Neto, Herbert Leonel de Matos-Guedes, Daniel Cláudio de Oliveira Gomes, Marilene Marcuzzo do Canto-Cavalheiro, Bartira Rossi-Bergmann, Eduardo Caio Torres-Santos   +5 more
doaj   +1 more source

Prob-cGAN: A Probabilistic Conditional Generative Adversarial Network for LSD1 Inhibitor Activity Prediction [PDF]

arXiv
The inhibition of Lysine-Specific Histone Demethylase 1 (LSD1) is a promising strategy for cancer treatment and targeting epigenetic mechanisms. This paper introduces a Probabilistic Conditional Generative Adversarial Network (Prob-cGAN), designed to predict the activity of LSD1 inhibitors.
arxiv  

Untersuchungen über eine mikrosomale N-Demethylase in verschiedenen Organen der Ratte in vitro [PDF]

, 1966
M. Knecht
openalex   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

A 4-Methoxybenzoate O-Demethylase from Pseudomonas putida. A New Type of Monooxygenase System [PDF]

, 1975
Frithjof‐Hans BERNHARDT, Heinz PACHOWSKY, H. Staudinger   +2 more
openalex   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, EarlyView.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source