Results 201 to 210 of about 53,955 (247)
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Lysine demethylases and cancer
Pathology - Research and PracticeEpigenetic mechanisms are of pivotal importance in the normal development and maintenance of cell and tissue-specific gene expression patterns, and are fundamental to the genesis of cancer. One significant category of epigenetic modifications is histone methylation.
Tomas, Eckschlager +2 more
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Opiate target site N-demethylase enzymes: Differences from the liver N-demethylase
Biochemical and Biophysical Research Communications, 1979Abstract Mixtures of morphine-63H and morphine-N-14CH3 were incubated with rat brain subcellular fractions. Isotope ratio measurements served as the marker for identification, purification and quantitation of N-nor products which were shown to consist almost solely of N-normorphine.
E F, Hahn, B I, Norton, J, Fishman
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Recent Progress in Histone Demethylase Inhibitors
Journal of Medicinal Chemistry, 2016There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC
McAllister +6 more
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In Vitro Histone Demethylase Assays
2009Histone methylation plays important roles in chromatin structure, transcription, and epigenetic state of the cell. Tremendous discoveries recently demonstrated that methylation mark is not static but is dynamically regulated by both histone methyltransferases and the histone demethylases.
Kenji, Kokura, Jia, Fang
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Histone methylation is a dynamic process that contributes to the control of gene expression by influencing chromatin structure. Since their initial discovery 20 years ago, histone demethylases have been shown to play a critical role in histone methylation and thus developmental, physiological, and pathological processes.
Stephen C. Kales, Anton Simeonov
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Stephen C. Kales, Anton Simeonov
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In Vitro Histone Demethylase Assays
2015Histone methylation plays pivotal roles in modulating chromatin structure and dynamics and in turn regulates genomic processes that require access to the DNA template. The methylation status at different sites is dynamically regulated by histone methyltransferases and demethylases. During the past decade, two classes of proteins have been characterized
Kenji, Kokura, Lidong, Sun, Jia, Fang
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KDM5 demethylases and their role in cancer cell chemoresistance
International Journal of Cancer, 2018Histone methylation is important in the regulation of genes expression, and thus its dysregulation has been observed in various cancers. KDM5 enzymes are capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4) which makes them ...
Johana Plch, J. Hraběta, T. Eckschlager
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The role of RNA adenosine demethylases in the control of gene expression.
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, 2019RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease.
Veronika Rájecká +2 more
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H3K9 demethylases IBM1 and JMJ27 are required for male meiosis in Arabidopsis thaliana.
New Phytologist, 2022Jinping Cheng +9 more
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