Diffusion Kurtosis Imaging maps neural damage in the EAE model of multiple sclerosis [PDF]
arXiv, 2018 Diffusion kurtosis imaging (DKI), is an imaging modality that yields novel disease biomarkers and in combination with nervous tissue modeling, provides access to microstructural parameters. Recently, DKI and subsequent estimation of microstructural model parameters has been used for assessment of tissue changes in neurodegenerative diseases and their ...
arxiv
The effect of realistic geometries on the susceptibility-weighted MR signal in white matter [PDF]
, 2017 Purpose: To investigate the effect of realistic microstructural geometry on the susceptibility-weighted magnetic resonance (MR) signal in white matter (WM), with application to demyelination. Methods: Previous work has modeled susceptibility-weighted signals under the assumption that axons are cylindrical. In this work, we explore the implications of
arxiv +1 more source
Demyelinating disease masquerading as a surgical problem: a case series
Journal of Medical Case Reports, 2009 Introduction We report three cases of demyelinating disease with tumor-like presentation. This information is particularly important to both neurosurgeons and neurologists who should be aware that inflammatory demyelinating diseases can present as a mass
Awang Saufi M +4 more
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Bypassing damaged nervous tissue [PDF]
arXiv, 2016 It is shown the principal possibility of bypassing damaged demyelinated portions of the nervous tissue, thereby restoring its normal function for the passage of action potentials.
arxiv +1 more source
Multivariate MR Biomarkers Better Predict Cognitive Dysfunction in Mouse Models of Alzheimers Disease [PDF]
arXiv, 2018 To understand multifactorial conditions such as Alzheimers disease (AD) we need brain signatures that predict the impact of multiple pathologies and their interactions. To help uncover the relationships between brain circuits and cognitive markers we have used mouse models that represent, at least in part, the complex interactions altered in AD.
arxiv
Demyelinating Disease Following Anti-TNFa Treatment (Adalimumab) in Patients with psoriasis: A Case Report (PP-13) [PDF]
Neurology Letters, 2023 Tumor necrosis factor antagonists (anti-TNFa) are an established therapeutic option for several autoimmune and inflammatory bowel diseases. Despite their clinical effectiveness, neurological adverse events have been reported and literature data suggest a
Mohammadreza Malek Zadeh
doaj
Multiple sclerosis lesion enhancement and white matter region estimation using hyperintensities in FLAIR images [PDF]
arXiv, 2018 Multiple sclerosis (MS) is a demyelinating disease that affects more than 2 million people worldwide. The most used imaging technique to help in its diagnosis and follow-up is magnetic resonance imaging (MRI). Fluid Attenuated Inversion Recovery (FLAIR) images are usually acquired in the context of MS because lesions often appear hyperintense in this ...
arxiv
Multiple sclerosis and herpesvirus interaction
Arquivos de Neuro-Psiquiatria, 2013 Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components.
Guilherme Sciascia do Olival +10 more
doaj +1 more source
Multiple Sclerosis Lesion Inpainting Using Non-Local Partial Convolutions [PDF]
arXiv, 2018 Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that results in focal injury to the grey and white matter. The presence of white matter lesions biases morphometric analyses such as registration, individual longitudinal measurements and tissue segmentation for brain volume measurements.
arxiv
The central vein sign in multiple sclerosis: a biomarker evaluated on a 3T MRI scanner
Clinical and Biomedical Research, 2021 The central vein sign (CVS) is a promising MRI biomarker in multiple sclerosis (MS). CVS has recently been proposed to improve the accuracy and speed of MS diagnosis.
Lillian Goncalves Campos +5 more
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