Results 81 to 90 of about 9,225,670 (325)

Late‐onset epilepsy of unknown etiology is more treatment‐responsive than acquired lesional late‐onset epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Late‐onset epilepsy of unknown etiology (LOEU) carries an elevated risk of dementia, suggesting that it may represent an early manifestation of neurodegenerative or cerebrovascular disease. Direct comparisons between LOEU and acquired lesional late‐onset epilepsy (LOE) may elucidate clinical features specific to LOEU.
L. Brian Hickman, Bhavya Pandey, Alexander Fish, Mohit Bandla, Adnan Husein, Corinne Allas, Harika Kottakota, Lauren Herzog, Keith Vossel, John M. Stern   +9 more
wiley   +1 more source

Prolactin Receptor Deficiency Promotes Hypomyelination in White Matter Tracts During Postnatal Central Nervous System Maturation in Mice

Glia, EarlyView.
Prolactin action is essential for proper myelination of white matter tracts during neonatal and prepubertal stages in mice. Lack of prolactin receptor (Prlr−/−) signaling leads to hypomyelination and impaired locomotor function. ABSTRACT A large wave of myelination in the central nervous system (CNS) of mammals occurs during postnatal development ...
Ana L. Ocampo‐Ruiz, José L. Dena‐Beltrán, Marco A. Dimas‐Rufino, Ximena Castillo, Dina I. Vazquez‐Carrillo, Andrea Silos‐Guajardo, Xarubet Ruiz‐Herrera, Edith Garay, Gonzalo Martínez de la Escalera, Carmen Clapp, Rogelio O. Arellano, Abraham J. Cisneros‐Mejorado, Yazmín Macotela   +12 more
wiley   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

A clinical case with Anti-MOG associated demyelinating disease

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Relevance. Anti-MOG-associated diseases are a relatively new and poorly studied group of autoimmune demyelinating disorders. Description of clinical cases helps to expand the understanding of the pathology, its diagnosis and treatment.
D. A. Bazhenova, E. I. Zaydullina, A. A. Malkova, N. V. Komissarova   +3 more
doaj   +1 more source

Acute‐onset chronic inflammatory demyelinating polyneuropathy with cranial nerves and respiratory tract involvement: A case report

Clinical Case Reports, 2020
Sixteen percent of chronic inflammatory demyelinating polyneuropathy (CIDP) patients may present acutely like acute idiopathic demyelinating polyneuropathy (AIDP) the demyelinating form of GBS, developing in
Malek Mansour, Asma Ouerdiene, Ines Bedoui, Amel Kacem, Jamel Zaouali, Ridha Mrissa   +5 more
doaj   +1 more source

Movement Disorders in Neuromyelitis Optica Spectrum Disorder: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Several movement disorders (MD) have been reported to occur in neuromyelitis optica spectrum disorder (NMOSD). No extensive review has addressed the whole spectrum of MD in NMOSD. Objective This article aims to review MD in NMOSD, describing its prevalence and features.
Luciana A.F. Bringel, Pedro L.G.S.B. Lima, Pedro V.F. Rodrigues, Francisco L.H.B. Cavalcante, Amanda R. Pinheiro, Fabricia M.S. Saraiva, Cynthia P. Rodrigues, Paulo V.S. Gonçalves, Leonardo J.R.A. Melo, Antônio E. Camelo‐Filho, Avelino M. Dutra‐Junior, Samuel R.O. Veras, Fernanda M.M. Carvalho, Flávia P.S. Rolim, Gabriela J. Martins, José A.C. D'Almeida, Pedro Braga‐Neto, Milena S. Pitombeira, Paulo R. Nobrega   +18 more
wiley   +1 more source

The impact of gut microbiome on neuro-autoimmune demyelinating diseases

Academia Biology
Demyelinating diseases, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and chronic inflammatory demyelinating polyneuropathy (CIDP), are characterized by dysregulated immune responses to self-antigens ...
Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold   +2 more
doaj   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Biallelic Variants in SLC27A3 Cause a Complex Form of Neurodegeneration with Brain Iron Accumulation

Movement Disorders, EarlyView.
Abstract Background Complex lipid metabolism is one of the main biological pathways disrupted in neurodegeneration with brain iron accumulation (NBIA). SLC27A3 gene encodes for the very long‐chain acyl‐CoA synthetase 3, an acyl‐CoA ligase that activates long and very long‐chain fatty acids.
Lorena Travaglini, Cherim Jeon, Teresa Rizza, Antonio Novelli, Nicola Specchio, Anna Piluso, Enrico Bertini, Arcangela Iuso, Giacomo Garone   +8 more
wiley   +1 more source

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

Movement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger, Chi Wang Ip   +1 more
wiley   +1 more source