Results 81 to 90 of about 9,406,168 (354)

Treatment-related fluctuations in subacute inflammatory demyelinating polyneuropathy

eNeurologicalSci, 2020
Treatment-related fluctuation (TRF), only defined in Guillain-Barre syndrome (GBS), refer to the deterioration of symptoms following treatment-induced improvement, and implies disease activity lasting beyond the effect of immunotherapy.
Young Gi Min, Yoon-Ho Hong
doaj   +1 more source

COVID-19 and the risk of CNS demyelinating diseases: A systematic review

Frontiers in Neurology, 2022
BackgroundViral infections are a proposed possible cause of inflammatory central nervous system (CNS) demyelinating diseases, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein ...
Itay Lotan, Shuhei Nishiyama, Giovanna S. Manzano, Melissa Lydston, Michael Levy   +4 more
doaj   +1 more source

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. [PDF]

, 2014
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis.
Blanc, Caroline A, Lane, Thomas E, Rosen, Hugh   +2 more
core   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

Brain-Derived Neurotrophic Factor in Multiple Sclerosis Disability: A Prospective Study

Brain Sciences
Multiple sclerosis (MS) is a demyelinating central nervous system disease that leads to neurological disability. Brain-derived neurotrophic factors (BDNFs) are neurotrophins involved in neurodegenerative disorders.
Vitalie Vacaras, Andreea-Cristina Paraschiv, Silvina Iluț, Cristiana Vacaras, Cristina Nistor, Gheorghe-Eduard Marin, Andra Maria Schiopu, Dorian-Traian Nistor, Ștefan Cristian Vesa, Dafin Fior Mureșanu   +9 more
doaj   +1 more source

HIV positive patient with GBS-like syndrome [PDF]

, 2017
Introduction. Guillain–Barré Syndrome (GBS) is an acute demyelinating polyneuropathy which can occur post-infection. Criteria of diagnosis of GBS include areflexia with progressive bilateral weakness in arms and legs.
Black, Heather, Gunson, Rory N., Shepherd, Samantha J., Thomson, Emma C.   +3 more
core   +1 more source

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Inflammatory demyelinating polyneuropathy versus leptomeningeal disease following Ipilimumab

Journal for ImmunoTherapy of Cancer, 2018
Background Ipilimumab is an FDA-approved anti-CTLA-4 monoclonal antibody used in treatment of metastatic melanoma. We present an unusual neurological complication of Ipilimumab therapy and the diagnostic dilemma it caused. Case presentation A 42 year old
Lorraine Cafuir, David Lawson, Nilesh Desai, Vita Kesner, Alfredo Voloschin   +4 more
doaj   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source

CD8+ T Cells Are Required For Glatiramer Acetate Therapy in Autoimmune Demyelinating Disease

PLoS ONE, 2013
The exact mechanism of glatiramer acetate (GA, Copaxone®), an FDA-approved immunomodulatory therapy for multiple sclerosis (MS), remains unclear after decades of research. Previously, we have shown that GA therapy of MS induces CD8+ T cell responses that
A. Tyler, Jason P. Mendoza, Mihail Firan, Nitin J. Karandikar   +3 more
semanticscholar   +1 more source