Macrophages and Autoantibodies in Demyelinating Diseases
Cells, 2021 Myelin phagocytosis by macrophages has been an essential feature of demyelinating diseases in the central and peripheral nervous systems, including Guillain–Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multiple ...
Haruki Koike, Masahisa Katsuno
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COVID-19 and the risk of CNS demyelinating diseases: A systematic review
Frontiers in Neurology, 2022 BackgroundViral infections are a proposed possible cause of inflammatory central nervous system (CNS) demyelinating diseases, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein ...
Itay Lotan +4 more
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Peripheral Demyelinating Diseases: From Biology to Translational Medicine
Frontiers in Neurology, 2019 Demyelinating diseases represent a spectrum of disorders that impose significant burden on global economy and society. Generally, the prognosis of these diseases is poor and there is no available cure.
Khidhir Kamil +4 more
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Pregnancy-Related Immune Changes and Demyelinating Diseases of the Central Nervous System
Frontiers in Neurology, 2019 Demyelinating diseases of the central nervous system comprise a heterogeneous group of autoimmune disorders characterized by myelin loss with relative sparing of axons occurring on a background of inflammation.
Ke Qiu +5 more
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Central nervous system demyelinating diseases: glial cells at the hub of pathology
Frontiers in Immunology, 2023 Inflammatory demyelinating diseases (IDDs) are among the main causes of inflammatory and neurodegenerative injury of the central nervous system (CNS) in young adult patients.
Vinicius Gabriel Coutinho Costa +3 more
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Journal of Materials Science: Materials in Medicine, 2023 Peripheral demyelinating diseases entail damage to axons and Schwann cells in the peripheral nervous system. Because of poor prognosis and lack of a cure, this group of diseases has a global impact. The primary underlying cause of these diseases involves
Aishwarya Nagarajan +8 more
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Myelin oligodendrocyte glycoprotein antibody-associated disorders: clinical spectrum, diagnostic evaluation, and treatment options [PDF]
Clinical and Experimental Pediatrics, 2021 Inflammatory or immune-mediated demyelinating central nervous system (CNS) syndromes include a broad spectrum of clinical phenotype and different overlapping diseases.
Yun-Jin Lee +4 more
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Ferroptosis and central nervous system demyelinating diseases
Journal of Neurochemistry, 2023 Ferroptosis is a newly discovered programmed cell death caused by intracellular iron excess and glutathione (GSH) system imbalance, resulting in fatal lipid peroxidation. It is different from necrosis, apoptosis, autophagy, and other forms of cell death.
D. Qin +3 more
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Existing Evidence for the Repurposing of PARP-1 Inhibitors in Rare Demyelinating Diseases
Cancers, 2022 Simple Summary Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors are successful cancer therapeutics that impair DNA repair machinery, leading to an accumulation of DNA damage and consequently cell death.
Marianna Mekhaeil +2 more
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Immunopathology of Tumefactive Demyelinating Lesions-From Idiopathic to Drug-Related Cases
Frontiers in Neurology, 2022 Tumefactive demyelinating lesions (TDL) represent a diagnostic dilemma for clinicians, and in rare atypical cases a collaboration of a neuroradiologist, a neurologist, and a neuropathologist is warranted for accurate diagnosis.
Aigli G. Vakrakou +5 more
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