Results 71 to 80 of about 56,601 (283)

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Genes, brain dynamics and art: the genetic underpinnings of creativity in dancing, musicality and visual arts

Journal of Integrative Neuroscience, 2021
Creativity, art and artistic creation in music, dance and visual arts are brain activities specific to humans. Their genetic background remained unexplored for years, but many recent studies have uncovered significant associations with cognition ...
Marinos G. Sotiropoulos, Maria Anagnostouli   +1 more
doaj   +1 more source

Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases [PDF]

, 2019
International audienceAutoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating syndromes (ADS) and physiopathology is still under investigation. As cynomolgus macaques immunized
Marignier, Romain, Adam, Clovis, Stimmer, Lev, Tchitchek, Nicolas, Perrin, Audrey, Contreras, Vanessa, Hart, Bertt, Fovet, Claire-Maëlle, Hart, Bert‘t, Massonneau, Julie, Leroy, Carole, Boutonnat, Jean, Hart, Bert't, Le-Grand, Roger, Horellou, Philippe, Flament, Julien, Hantraye, Philippe, Chrétien, Pascale, Serguera, Che, Deiva, Kumaran, Demilly, Joanna   +20 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Mechanisms of remyelination: recent insight from experimental models

Biomolecular Concepts, 2014
Oligodendrocytes and myelin play essential roles in the vertebrate central nervous system. Demyelination disrupts saltatory nerve conduction, leading to axonal degeneration and neurological disabilities.
Tanaka Tatsuhide, Yoshida Shigetaka
doaj   +1 more source

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorders: Toward a New Spectrum of Inflammatory Demyelinating CNS Disorders?

Frontiers in Immunology, 2018
Inflammatory demyelinating CNS syndromes include, besides their most common entity multiple sclerosis (MS), several different diseases of either monophasic or recurrent character—including neuromyelitis optica spectrum disorders (NMOSDs) and acute ...
Franziska Di Pauli, Thomas Berger
doaj   +1 more source

Mitochondrial Genome Profile in Demyelinating Diseases

, 2013
Multiple sclerosis and neuromyelitis optica are chronic inflammatory diseases of the central nervous system. These pathologies share clinical similarities with Leber hereditary optic neuropathy, which is primarily due to mutations of mitochondrial DNA.
CORTESE, ANTONIO, e. wang, v. durastanti, fm maricola, MILLEFIORINI, Enrico, CARONTI, Brunella, BERARDELLI, Alfredo, a. monaco, FUSTAINO, VALENTINA   +8 more
core   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Optical coherent tomography capabilities in the diagnosis of demyelinating diseases of the central nervous system

Анналы клинической и экспериментальной неврологии, 2018
Optical coherence tomography (OCT) is a non-invasive technique routinely used for obtaining in vivo transverse images of tissues. In the field of neurology, OCT is used to assess retinal changes in various diseases, including multiple sclerosis ...
Natalia V. Polekhina, Zoya V. Surnina, Maria N. Zakharova   +2 more
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source