Results 41 to 50 of about 540,123 (302)

Fluorescent Calixarene-Schiff as a Nanovehicle with Biomedical Purposes

Chemosensors, 2022
Gene therapy is a technique that is currently under expansion and development. Recent advances in genetic medicine have paved the way for a broader range of therapies and laid the groundwork for next-generation technologies.
José Antonio Lebrón, Manuel López-López, María Luisa Moyá, Mary Deasy, Ana Muñoz-Wic, Clara Beatriz García-Calderón, Iván Valle Rosado, Pilar López-Cornejo, Eva Bernal, Francisco José Ostos   +9 more
doaj   +1 more source

Blinking statistics of a molecular beacon triggered by end-denaturation of DNA

, 2005
We use a master equation approach based on the Poland-Scheraga free energy for DNA denaturation to investigate the (un)zipping dynamics of a denaturation wedge in a stretch of DNA, that is clamped at one end.
Ambjörnsson T, Ambjörnsson T, Ambjörnsson T, Ambjörnsson T, Ambjörnsson T Metzler R, Hanke A, Krichevsky O, Ledermann W, Lehn J-M, Meller A, Ralf Metzler, Risken H, Tobias Ambjörnsson, van Kampen N G   +13 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effects of Different Denaturants on the Properties of a Hot-Pressed Peanut Meal-Based Adhesive

Molecules, 2022
Plant protein-based adhesives could fundamentally solve the problem of formaldehyde-based adhesive releasing formaldehyde, but enhancing bonding strength and water resistance is a necessary measure to realize practical applications.
Yang Qu, Qin Guo, Tian Li, Hongzhi Liu, Qiang Wang   +4 more
doaj   +1 more source

Thermal Denaturation of Fluctuating DNA Driven by Bending Entropy

, 2007
A statistical model of homopolymer DNA, coupling internal base pair states (unbroken or broken) and external thermal chain fluctuations, is exactly solved using transfer kernel techniques.
Destainville, N., Manghi, M., Palmeri, J.   +2 more
core   +3 more sources

Multiple timescales in a model for DNA denaturation dynamics [PDF]

, 2009
The denaturation dynamics of a long double-stranded DNA is studied by means of a model of the Poland-Scheraga type. We note that the linking of the two strands is a locally conserved quantity, hence we introduce local updates that respect this symmetry ...
Alberts B, Blake R D, de Gennes P G, Dean F B, Drukker K, Duke T A J, Hanke A, Kabakçıoğlu A Orlandini E Mukamel D, Kafri Y, Kunz H, Marco Baiesi, Novotny T, Paul W, Peyrard M, Poland D, Roberto Livi, Rubinstein M, van Heukelum A, Wartell R M   +18 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Thermal Denaturation of Milk Whey Proteins: A Comprehensive Review on Rapid Quantification Methods Being Studied, Developed and Implemented

Dairy, 2022
Heat treatment of milk signifies a certain degree of protein denaturation, which modifies the functional properties of dairy products. Traditional methods for detecting and quantifying the denaturation of whey proteins are slow, complex and require ...
Paulina Freire, Allison Zambrano, Anna Zamora, Manuel Castillo   +3 more
doaj   +1 more source

Test of cold denaturation mechanism for proteins as a function of water's structure

, 2006
In a recent paper [PRL 91, 138103 (2003)] a new mechanism to explain the cold denaturation of proteins, based on the loss of local low-density water structure, has been proposed.
Berendsen, Bruscolini, Chan, Chan, Chandler, Cheung, Collet, Dill, Finney, Frank, Ghosh, Hansen, Hummer, Jonas, Kauzmann, Larini, Lee, Manuel I. Marqués, Marqués, McCarthy, Melchionna, Pace, Paschek, Pierotti, Pratt, Privalov, Privalov, Scala, Shimizu, Silverstein, Smeller, Southhall, Starr, Steinhauser, Stillinger, Trovato, Vanderzande, Zhang, Zipp   +38 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source