Results 61 to 70 of about 131,881 (286)

Physical properties of apoprotein B in mixed micelles with sodium deoxycholate and in a vesicle with dimyristoyl phosphatidylcholine.

Journal of Lipid Research, 1987
Apoprotein B, the major apoprotein of normal human low density lipoprotein (LDL) was solubilized with sodium deoxycholate (NaDC). The protein was recombined with the phospholipid dimyristoyl phosphatidylcholine (DMPC) to produce a complex of DMPC-apoB (4:
M T Walsh, D Atkinson
doaj   +1 more source

Twist versus Nonlinear Stacking in Short DNA Molecules

, 2014
The denaturation of the double helix is a template for fundamental biological functions such as replication and transcription involving the formation of local fluctuational openings.
Zoli, Marco
core   +1 more source

Statistical mechanics of RNA folding: a lattice approach [PDF]

, 2003
We propose a lattice model for RNA based on a self-interacting two-tolerant trail. Self-avoidance and elements of tertiary structure are taken into account.
A. Pagnani, B. Derrida, C. Vanderzande, D. Marenduzzo, D.S. Gaunt, E. Carlon, E. Orlandini, F. Krzakala, H. Orland, H.A. Lim, I. Tinoco, J. Chahine, J. Liphardt, J.A. Marqusee, J.S. McCaskill, K. De’Bell, M. Müller, M.C. Tesi, M.S. Causo, N. Madras, P. Grassberger, P. Leoni, P.G. Higgs, P.G. Higgs, R. Bundschuh, R. Bundschuh, R. Bundschuh, S. Cocco, S. Doniach, T.R. Strick, Y. Kafri   +30 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Denaturation of Circular DNA: Supercoil Mechanism

, 2011
The denaturation transition which takes place in circular DNA is analyzed by extending the Poland-Scheraga model to include the winding degrees of freedom.
Alkan Kabakçoğlu, Amir Bar, David Mukamel, H. Hiasa, L. Lewin, M. Abramowitz, Y. Kafri   +6 more
core   +1 more source

Lyapunov exponents as a dynamical indicator of a phase transition [PDF]

, 2001
We study analytically the behavior of the largest Lyapunov exponent $\lambda_1$ for a one-dimensional chain of coupled nonlinear oscillators, by combining the transfer integral method and a Riemannian geometry approach.
, Garel T., J Barré, Kockelkoren J., Lichtenberg A. J., Mac Kay R. S., Manneville P., Pikovsky A., T Dauxois, Theodorakopoulos N.   +9 more
core   +3 more sources

Rare Dissipative Transitions Punctuate the Initiation of Chemical Denaturation in Proteins [PDF]

Biophysical Journal, 2018
Protein unfolding dynamics are bound by their degree of entropy production, a quantity that relates the amount of heat dissipated by a nonequilibrium process to a system's forward and time-reversed trajectories. We here explore the statistics of heat dissipation that emerge in protein molecules subjected to a chemical denaturant.
Jeffrey K, Weber, Seung-Gu, Kang, Ruhong, Zhou   +2 more
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Differences in pressure and temperature transitions of proteins and polymer gels

Brazilian Journal of Medical and Biological Research, 2005
Pressure-driven and temperature-driven transitions of two thermoresponsive polymers, poly(N-isopropylacrylamide) (pNIPAM) and poly(N-vinylisobutyramide) (pNVIBA)), in both a soluble linear polymer form and a cross-linked hydro-gel form, were examined by ...
S. Kunugi, K. Kameyama, T. Tada, N. Tanaka, M. Shibayama, M. Akashi   +5 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source