Results 131 to 140 of about 54,440 (362)

Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest

open access: yesACS Nano, 2014
Treatment of brain injury following circulatory arrest is a challenging health issue with no viable therapeutic options. Based on studies in a clinically relevant large animal (canine) model of hypothermic circulatory arrest (HCA)-induced brain injury ...
M. Mishra   +11 more
semanticscholar   +1 more source

Controlled Growth of Oligophenylene‐Structures on Graphene for Facile Secondary functionalization.

open access: yesAngewandte Chemie International Edition, Accepted Article.
Functionalization of graphene derivatives is a common approach to tune material properties for use in various applications. Due to the low reactivity of the unsaturated carbon lattice of graphene, not only are few chemical approaches suitable for successful functionalization, such as those involving highly reactive in situ formed radical species or ...
Christian Eberhard Halbig   +6 more
wiley   +1 more source

Development of Tat-Conjugated Dendrimer for Transdermal DNA Vaccine Delivery

open access: yesJournal of Pharmacy & Pharmaceutical Sciences, 2016
PURPOSE: In order to enhance cellular uptake and to facilitate transdermal delivery of DNA vaccine, polyamidoamine (PAMAM) dendrimers conjugated with HIV transactivator of transcription (TAT) was developed.
Azadeh Bahadoran   +4 more
doaj   +1 more source

Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. [PDF]

open access: green, 1996
Jolanta F. Kukowska‐Latallo   +5 more
openalex   +1 more source

Functional Dendrimer Nanogels for DNA Delivery and Gene Therapy of Tumors

open access: yesAngewandte Chemie International Edition, Accepted Article.
Solving the dilemma between efficacy and cytotoxicity of cationic colloidal vectors is one of the biggest challenges in gene delivery. Cationic dendrimer assemblies with hierarchical structure, smart and biomimetic behaviors have been developed for drug/gene delivery in vivo.
Xin Li   +7 more
wiley   +1 more source

Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture

open access: yesMolecules, 2018
Polyamidoamine (PAMAM) dendrimers are multifunctional nanoparticles with tunable physicochemical features, making them promising candidates for targeted drug delivery in the central nervous system (CNS).
Yossef Alnasser   +7 more
doaj   +1 more source

Five Generations of Nitroxyl-Functionalized Dendrimers [PDF]

open access: green, 1997
Anton W. Bosman   +2 more
openalex   +1 more source

Efficient Synthesis of Macromolecular DO3A@Gn Derivatives for Potential Application in MRI Diagnostics: From Polymer Conjugates to Polymer Nanoparticles

open access: yesMacromolecular Chemistry and Physics, Volume 224, Issue 1, January 2023., 2023
Herein, poly(2‐oxazoline) homo‐ and copolymers are used for functionalization with the 1,4,7,10‐tetraazacyclododecane‐N,N,N,N‐tetraacetic acid chelator and subsequent complexation with Gn(III). The resulting conjugates are utilized for micelle and nanoparticle formation and are further analyzed and compared toward their relaxivity as a prerequisite for
Anne‐Larissa Kampmann   +2 more
wiley   +1 more source

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature.

open access: yesNano letters (Print), 2014
Targeted RNA delivery to lung endothelial cells has the potential to treat conditions that involve inflammation, such as chronic asthma and obstructive pulmonary disease.
Omar F. Khan   +14 more
semanticscholar   +1 more source

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