Results 71 to 80 of about 165,498 (276)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease

Scientific Reports
Dendrite defects and loss are early cellular alterations observed across neurodegenerative diseases that play a role in early disease pathogenesis.
Sydney E. Prange, Isha N. Bhakta, Daria Sysoeva, Grace E. Jean, Anjali Madisetti, Hieu H. N. Le, Ly U. Duong, Patrick T. Hwu, Jaela G. Melton, Katherine L. Thompson-Peer   +9 more
doaj   +1 more source

A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. [PDF]

, 2019
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the ...
Clanton, Joshua A, Cronan, Mark R, Jiang, Nan, Kim, Hyeon-Jin, Luedke, Kory P, Parker, Edward D, Parrish, Jay Z, Rasmussen, Jeffrey P, Rosenberg, Marci F, Sagasti, Alvaro, Vaughan, Joshua C   +10 more
core  

Crossover Scaling in Dendritic Evolution at Low Undercooling

, 1999
We examine scaling in two-dimensional simulations of dendritic growth at low undercooling, as well as in three-dimensional pivalic acid dendrites grown on NASA's USMP-4 Isothermal Dendritic Growth Experiment.
A. A. Wheeler, A. A. Wheeler, A. Karma, Afina Lupulescu, D. A. Kessler, D. A. Kessler, E. Ben-Jacob, E. Brener, G. Caginalp, G. Caginalp, G. Caginalp, J. A. Warren, J. B. Collins, J. Ignés-Mullol, J. S. Langer, Jeffrey C. LaCombe, Jonathan Dantzig, K. R. Elder, M. B. Koss, M. E. Glicksman, M. E. Glicksman, M. Muschol, Martin E. Glicksman, Matthew B. Koss, N. Provatas, N. Provatas, N. Provatas, Nigel Goldenfeld, Nikolas Provatas, Q. Li, R. Almgren, R. Almgren, R. J. Braun, R. Kobayashi, Robert Almgren, S.-C. Huang, S.-L. Wang, U. Bisang, Y. Pomeau   +38 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Dendritic flux patterns in MgB2 films

, 2001
Magneto-opitcal studies of a c-oriented epitaxial MgB2 film with critical current density 10^7 A/cm^2 demonstrate a breakdown of the critical state at temperatures below 10 K [cond-mat/0104113].
D V Shantsev, E M Choi, Frello T, H J Kim, Johansen T H, Johansen T H, M Baziljevich, M-S Kim, P E Goa, S I Lee, T H Johansen, W N Kang, Y M Galperin, Zhao Z W, Zhao Z W   +14 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Mechanical deformations of bone generate interstitial fluid flow at nanoscale velocities around osteocytes

Frontiers in Bioengineering and Biotechnology
Osteocytes play a critical role in bone mechanobiology, sensing and responding to mechanical loading through fluid flow within the lacunar-canalicular network (LCN).
Asier Muñoz, Annalisa De Paolis, Luis Cardoso, Alessandra Carriero   +3 more
doaj   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source