Results 41 to 50 of about 18,648 (256)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Recent Advances in Dendrite Suppression Strategies for Solid-State Lithium Batteries: From Interface Engineering to Material Innovations

Batteries
Solid-state lithium batteries (SSLBs) have emerged as a promising alternative to conventional lithium-ion systems due to their superior safety profile, higher energy density, and potential compatibility with lithium metal anodes.
Abniel Machín, Francisco Díaz, María C. Cotto, José Ducongé, Francisco Márquez   +4 more
doaj   +1 more source

Suppressing the Shuttle Effect and Dendrite Growth in Lithium–Sulfur Batteries [PDF]

ACS Nano, 2020
Practical applications of lithium-sulfur batteries are simultaneously hindered by two serious problems occurring separately in both electrodes, namely, the shuttle effects of lithium polysulfides and the uncontrollable growth of lithium dendrites. Herein, to explore a facile integrated approach to tackle both problems as well as guarantee the efficient
Jianan Wang, Shanshan Yi, Jianwei Liu, Shiyi Sun, Yunpeng Liu, Duowen Yang, Kai Xi, Guoxin Gao, Amr Abdelkader, Wei Yan, Shujiang Ding, Ramachandran Vasant Kumar   +11 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Simulation of Dendrite Growth with a Diffusion-Limited Aggregation Model Validated by MRI of a Lithium Symmetric Cell during Charging

Batteries
Lithium metal batteries offer high energy density but are challenged by dendrite growth, which can lead to short circuits and battery failure. Multiple models with varying degrees of accuracy and computational cost have been developed to understand and ...
Rok Peklar, Urša Mikac, Igor Serša
doaj   +1 more source

Leishmania Regulated MTDH Expression to Suppress Dendritic Cells.

The Tohoku journal of experimental medicine, 2022
This study aimed to investigate the correlation between Leishmania infection and dendritic cell infiltration and explore the underlying molecular mechanism how Leishmania infection regulates dendritic cell infiltration. Three datasets, GSE63931, GSE80008 and GSE77528 were combined and their batch effects were removed by Combat function in sva R package.
Tang, Lu, Yu, Siyang, Dong, Baijing, Zhang, Shengkun, Xu, Wanzhen, Wei, Lanlan, Chu, Ming   +6 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dendrite Growth Suppression in Lithium Metal Batteries with Composite Quasi-solid Electrolytes [PDF]

한국정밀공학회지
Secondary batteries are crucial for eco-friendly systems, but existing technologies struggle with energy density and safety issues. This study aims to develop a next-generation battery utilizing quasi-solid electrolytes (QSE), which combine the ...
Jeongeun Park, Jinhyeong An, Jiwoong Bae
doaj   +1 more source