Results 51 to 60 of about 452,208 (292)

Assembly of sensory-motor connectivity in the spinal cord of mice [PDF]

, 2007
Many features critical for proper functioning of an organism are under the control of neuronal circuits. The building blocks for these circuits are formed early during embryogenesis and are generated by the specification of distinct neuronal types.
Vrieseling, Eline
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Dendrite-Embedded Platinum–Nickel Multiframes as Highly Active and Durable Electrocatalyst toward the Oxygen Reduction Reaction

, 2018
Pt-based nanoframe catalysts have been explored extensively due to their superior activity toward the oxygen reduction reaction (ORR). Herein, we report the synthesis of Pt–Ni multiframes, which exhibit the unique structure of tightly fused multiple ...
Mrinal Kanti Kabiraz, Hionsuck Baik (1596526), Kwangyeol Lee, Hyukbu Kwon, Sang-Il Choi (734363), Hionsuck Baik, Jongsik Park (4109467), Aram Oh (1631836), Kwangyeol Lee (1428835), Sang-Il Choi, Hyukbu Kwon (4517533), Mrinal Kanti Kabiraz (4517536), Aram Oh, Jongsik Park   +13 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Dendrite-Free Composite Li Anode Assisted by Ag Nanoparticles in a Wood-Derived Carbon Frame

, 2019
Using lithium metal as anode in lithium batteries has attracted great attention due to its ultrahigh theoretical capacity of 3860 mA h g–1. However, the uneven deposition of lithium will cause dendrites, resulting in a poor cycling performance. Herein, a
Shijun Liao, Shijun Liao (1396471), Guangli Zheng, Xijuan Yu (6680282), Zhiming Cui, Li Du, Guangli Zheng (6680279), Huiyu Song, Xilong Chen, Xijuan Yu, Xilong Chen (6113276), Shangfeng Jiang, Huiyu Song (1396480), Shangfeng Jiang (6680285), Li Du (397426), Zhiming Cui (1487593)   +15 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Numerical simulation of dendrite growth during solidification [PDF]

, 2006
A comprehensive probabilistic model for simulating dendrite morphology and investigating dendritic growth kinetics during solidification has been developed, based on a modified Cellular Automaton (mCA) for microscopic modeling of nucleation, growth of ...
Yao, X., Wang, H, Yao, X, He, B, B. He, H. Wang, Wang, H., Zhou, X, He, B., X. Zhou, Zhou, X., X. Yao   +11 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Computation-accelerated Design of Dendrite-free Li Batteries

, 2023
The main obstacle to the development of the next-generation Li-based batteries is the formation of Li dendrite on the anode surface. Li dendrite growth contributes to the reduction of coulombic efficiency, poor cycling performance, and internal short ...
Tantratian, Karnpiwat
core   +1 more source