Results 81 to 90 of about 778,422 (341)
Transcriptional regulation of DC fate specification [PDF]
, 2020 Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further ...
Bosteels, Cedric, Scott, Charlotte
core +1 more source
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source
IOX1 impedes host inflammation in imiquimod-triggered psoriasis
Heliyon, 2021 Psoriasis is a chronic autoimmune disease with an unknown etiology and highly limited treatment strategies. The drugs currently used in the treatment of psoriasis are rarely recommended for long-term use owing to the serious side effects.
Joo Eun Shin +4 more
doaj
Travelling waves in a model of quasi-active dendrites with active spines [PDF]
, 2010 Dendrites, the major components of neurons, have many different types of branching structures and are involved in receiving and integrating thousands of synaptic inputs from other neurons.
Abbott +40 more
core +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Neuromodulatory control of localized dendritic spiking in critical period cortex. [PDF]
, 2019 Sensory experience in early postnatal life, during so-called critical periods, restructures neural circuitry to enhance information processing1. Why the cortex is susceptible to sensory instruction in early life and why this susceptibility wanes with age
Ringach, Dario L +2 more
core
Residence times of receptors in dendritic spines analyzed by simulations in empirical domains [PDF]
, 2014 Analysis of high-density superresolution imaging of receptors reveal the organization of dendrites at the nano-scale resolution. We present here simulations in empirical live cell images, which allows converting local information extracted from short ...
Holcman, D., Hoze, N.
core +2 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages
Scientific Reports, 2017 Activated macrophages have a greater ability of phagocytosis against pathogens that is mediated by large-scale actin rearrangement. However, molecular machineries that conduct this task have not been fully identified.
Hye-Ran Kim +10 more
doaj +1 more source