Results 81 to 90 of about 825,352 (312)

A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stages

Journal of Hematology & Oncology
Background The long-term effectiveness of immunotherapies against Multiple Myeloma (MM) remains elusive, demonstrated by the inevitable relapse in patients. This underscores the urgent need for an in-depth analysis of the MM tumor-immune microenvironment
Emma Verheye, Daliya Kancheva, Hatice Satilmis, Niels Vandewalle, Rong Fan, Pauline M. R. Bardet, Emile J. Clappaert, Kevin Verstaen, Ann De Becker, Karin Vanderkerken, Kim De Veirman, Damya Laoui   +11 more
doaj   +1 more source

An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages

Scientific Reports, 2017
Activated macrophages have a greater ability of phagocytosis against pathogens that is mediated by large-scale actin rearrangement. However, molecular machineries that conduct this task have not been fully identified.
Hye-Ran Kim, Hyun-Su Lee, Kyung-Sik Lee, In Duk Jung, Min-Sung Kwon, Chang-Hyun Kim, Seong-Min Kim, Myung-Han Yoon, Yeong-Min Park, Sang-Myeong Lee, Chang-Duk Jun   +10 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells

OncoImmunology
Bispecific antibodies are used for the treatment of hematological malignancies as well as solid tumors. One of their main effector mechanisms is the recruitment of effector cells such as CD8+ T cells and CD16A+ NK cells to tumor cells.
Lukas Heger, Tomasz Kaszubowski, Lukas Amon, Christian H. K. Lehmann, Susanne Wingert, José Medina-Echeverz, Joachim Koch, Holger Hackstein, Ariawan Purbojo, Arndt Hartmann, Christoph Alexiou, Robert Cesnjevar, Jens Pahl, Diana Dudziak   +13 more
doaj   +1 more source

Optimal sizes of dendritic and axonal arbors in a topographic projection

, 1999
I consider a topographic projection between two neuronal layers with different densities of neurons. Given the number of output neurons connected to each input neuron (divergence) and the number of input neurons synapsing on each output neuron ...
Chklovskii, Dmitri B.
core   +2 more sources

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Protocol for mapping the heterogeneous dendritic cell network across the murine tissue landscape via high-dimensional flow cytometry

STAR Protocols
Summary: Dendritic cells (DCs) populate nearly all tissues and represent the central orchestrators of immunity. Here, we present a protocol for the mild but efficient preparation of single-cell suspensions from multiple murine tissues and the downstream ...
Lukas Amon, Anna Seichter, Damir Vurnek, Giorgi Tchitashvili, Isabel Heß, Lukas Heger, Christian H.K. Lehmann, Diana Dudziak   +7 more
doaj   +1 more source

Image informatics strategies for deciphering neuronal network connectivity [PDF]

, 2016
Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions.
A Dani, A Rodriguez, A Rodriguez, A Rodriguez, B Deleglise, B Zhang, BA Wilt, C Sala, CG Dotti, D Cai, D Gerlich, D Popova, D Prodanov, D Smetters, DA Dombeck, DA Dombeck, DW Godwin, E Cohen, E Fluhler, E Meijering, E Meijering, E Meijering, EW Dent, F Cornelissen, F Janoos, G Pani, GG Gurkoff, GP Feng, GS Belinsky, H Bading, H Chen, H Peng, H Peng, HH Piao, IR Wickersham, IY Koh, J Cheng, J Fan, J Fan, J Lammerding, J Liu, J Livet, JA Harrill, JI Luebke, JL Chen, JM Nussbaum, K Chung, K Deisseroth, K Imamura, K Takahashi, KA Al-Kofahi, KD Micheva, KE Binley, KM Brown, KO Lai, KR Kay, L Bretzner, L Feng, L Grosenick, L Jin, L Jin, LD Costa, M Meijer, M Naujock, M Papa, M Pickering, M Pool, M Wittmann, ML Narro, MS Siegel, N Heck, O Sirenko, P Chothani, P Maiti, P Penzes, P Roqué, P Sarder, P Shi, P Verstraelen, Q Li, Q Li, R Nair, R Parekh, RA McKinney, RM Paredes, S Cho, S Schmitt, SK Schmitz, SL Wearne, SY Ho, SY Kim, T Nemoto, T Zhao, TL Fletcher, VA Alvarez, W Bai, WH Vos De, Y Al-Kofahi, Y Zhang, YC Lin   +99 more
core   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source