Results 91 to 100 of about 4,483,430 (258)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The influence of GABAergic signaling on dendritic processing [PDF]

, 2013
GABAergic (?-aminobutyric acid-releasing) signaling plays a crucial role in integration processes of pyramidal neurons. Specific subtypes of GABA releasing interneurons innervate different compartments of pyramidal neurons; thereby modulating the ...
Willadt, Silvia
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization [PDF]

, 2010
Contains fulltext : 88219.pdf (Publisher’s version ) (Open Access)BACKGROUND: Probiotics can be used to stimulate or regulate epithelial and immune cells of the intestinal mucosa and generate beneficial mucosal immunomodulatory effects.
Kleerebezem, M., Vos, P., de, Bilsen, J., van Bilsen Jolanda, Meijerink Marjolein, Savelkoul, H.F.J., Bron, P.A., Savelkoul Huub F., Bilsen, J.G.P.M., van, Huub F. Savelkoul, Wells Jerry M., Vos, P., Marjolein Meijerink, Bilsen, J. van, Jolanda van Bilsen, Bron, Peter A., Wells, J., Savelkoul, Huub F., de Vos Paul, Huub F Savelkoul, Saskia van Hemert, Vos, P. de, Michiel Wels, van Hemert Saskia, Meijerink, M., Jerry M Wells, Kleerebeezem, M., van Bilsen, Jolanda, Wels, Michiel, Kleerebezem, Michiel, Paul de Vos, Michiel Kleerebezem, Kleerebezem Michiel, Peter A. Bron, Taverne, Nico, Taverne Nico, Taverne, N., van Bilsen, J.G.P.M., van Hemert, Saskia, de Vos, Paul, Bron Peter A., Peter A Bron, de Vos, Paul; id_orcid, Wells, J.M., Savelkoul, H.F., van Hemert, S., de Vos, P., Wels Michiel, Nico Taverne, Hemert, S. van, Hemert, S., van, Wels, M., Wells, Jerry M., Jerry M. Wells, Wels, M.W.W., Sanders, M.W.W., Meijerink, Marjolein   +56 more
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Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Regulatory immune cells in transplantation. [PDF]

, 2012
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured ...
Bushell, Andrew, Wood, Kathryn, Bushell, A, Hester, J, Wood, Kathryn J, Andrew Bushell, Joanna Hester, Kathryn J. Wood, Wood, KJ, Hester, Joanna   +9 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis. [PDF]

, 2006
CD8 T lymphocytes are important effectors in protective immunity against Mycobacterium tuberculosis. We recently characterized the detour pathway of CD8 T cell activation in tuberculosis mediated by apoptotic vesicles from infected cells that transport ...
Hoops, Silvia Locatelli, Subash Sad, Sandhoff, Konrad, de Diego, Juana, Konrad Sandhoff, Bernadette Breiden, Kaufmann, Stefan H. E., Juana de Diego, Winau, Florian, Weber, Stephan, Sad, Subash, Silvia Locatelli Hoops, Kaufmann, Stefan H.E., Kaufmann, Stefan HE, Ulrich E. Schaible, Volker Brinkmann, Florian Winau, Breiden, Bernadette, Brinkmann, Volker, Schaible, Ulrich E, Schaible, Ulrich E., Stephan Weber, Stefan H.E. Kaufmann   +22 more
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Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo [PDF]

, 2004
Strategies to enhance the immunogenicity of tumors are urgently needed. Although vaccination with irradiated dying lymphoma cells recruits a tumor-specific immune response, its efficiency as immunogen is poor.
Zimmermann, VS, Voll, Reinhard E., Turnay, Javier, Manfredi, Angelo A., Turnay, J, Dumitriu, IE, Voll, RE, Zimmermann, Valérie S, Angelo A. Manfredi, Bertling, Wolf, Rovere-Querini, P, Kalden, JR, Udo S. Gaipl, Herrmann, M, Attilio Bondanza, Gaipl, Udo S, Wolf Bertling, Bertling, W, Patrizia Rovere-Querini, Ingrid E. Dumitriu, Bondanza, Attilio, Stach, Christian M., Pöschl, E, Stach, Christian M, Gaipl, US, Javier Turnay, Herrmann, Martin, Martin Herrmann, Dumitriu, Ingrid E., Rovere-Querini, Patrizia, Christian M. Stach, Manfredi, Angelo A, Kalden, Joachim R, Valérie S. Zimmermann, Pöschl, Ernst, Stach, CM, Dumitriu, Ingrid E; id_orcid, Gaipl, Udo S., Joachim R. Kalden, Bondanza, A, Zimmermann, Valérie S., Voll, Reinhard E, Kalden, Joachim R., Reinhard E. Voll, Manfredi, AA, Ernst Pöschl, Dumitriu IE, ROVERE QUERINI , PATRIZIA, Kalden JR, Bertling W, Turnay J, BONDANZA , ATTILIO, Herrmann M., Poschl E, Zimmermann VS, Gaipl US, Stach CM, MANFREDI , ANGELO ANDREA M. A., Voll RE   +58 more
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