Results 1 to 10 of about 6,856,628 (321)

Development and function of chicken XCR1+ conventional dendritic cells [PDF]

Frontiers in Immunology, 2023
Conventional dendritic cells (cDCs) are antigen-presenting cells (APCs) that play a central role in linking innate and adaptive immunity. cDCs have been well described in a number of different mammalian species, but remain poorly characterised in the ...
Zhiguang Wu, Barbara Shih, Barbara Shih, Joni Macdonald, Dominique Meunier, Kris Hogan, Cosmin Chintoan-Uta, Hazel Gilhooley, Tuanjun Hu, Mariana Beltran, Neil C. Henderson, Neil C. Henderson, Helen M. Sang, Mark P. Stevens, Michael J. McGrew, Adam Balic, Adam Balic   +16 more
doaj   +8 more sources

RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells [PDF]

Nature Communications, 2018
Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin.
Seika Hashimoto-Hill, Leon Friesen, Sungtae Park, Suji Im, Mark H. Kaplan, Chang H. Kim   +5 more
doaj   +5 more sources

The Role of Type-2 Conventional Dendritic Cells in the Regulation of Tumor Immunity. [PDF]

Cancers (Basel), 2022
Simple Summary Recent studies revealed that type-2 conventional dendritic cells (cDC2s) play an important role in antitumor immunity by promoting cytotoxic T-cell responses and helper T-cell differentiation.
Saito Y, Komori S, Kotani T, Murata Y, Matozaki T.   +4 more
europepmc   +3 more sources

Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4⁺ T cells through regulating type 2 conventional dendritic cells. [PDF]

Theranostics, 2023
Rationale: An immunosuppressive tumor microenvironment (TME) is a major obstacle in tumor immunotherapy. Stimulator of interferon genes (STING) agonists trigger an inflammatory innate immune response to potentially overcome tumor immunosuppression. While
Luo J, Pang S, Hui Z, Zhao H, Xu S, Yu W, Yang L, Sun Q, Hao X, Wei F, Wang J, Ren X.   +11 more
europepmc   +2 more sources

NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation. [PDF]

Redox Biol, 2023
Dendritic cells (DCs) undergo rapid metabolic reprogramming to generate signal-specific immune responses. The fine control of cellular metabolism underlying DC immune tolerance remains elusive.
Sen K, Pati R, Jha A, Mishra GP, Prusty S, Chaudhary S, Swetalika S, Podder S, Sen A, Swain M, Nanda RK, Raghav SK.   +11 more
europepmc   +2 more sources

Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer. [PDF]

Science
Inflammation and tissue damage associated with pancreatitis can precede or occur concurrently with pancreatic ductal adenocarcinoma (PDAC). We demonstrate that in PDAC coupled with pancreatitis (ptPDAC), antigen-presenting type I conventional dendritic ...
Mahadevan KK, Dyevoich AM, Chen Y, Li B, Sugimoto H, Sockwell AM, McAndrews KM, Sthanam LK, Wang H, Shalapour S, Watowich SS, Kalluri R.   +11 more
europepmc   +2 more sources

Circulating Plasmacytoid and Conventional Dendritic Cells Are Numerically and Functionally Deficient in Patients With Scrub Typhus

Frontiers in Immunology, 2021
BackgroundDendritic cells (DCs) are specialized antigen-presenting cells known to bridge innate and adaptive immune reactions. However, the relationship between circulating DCs and Orientia tsutsugamushi infection is unclear.
Seung-Ji Kang, Ki-Jeong Park, Hye-Mi Jin, Young-Nan Cho, Tae Hoon Oh, Seong Eun Kim, Uh Jin Kim, Kyung-Hwa Park, Sook-In Jung, Tae-Ok Kim, Hyo Shin Kim, Young-Goun Jo, Jae Kyun Ju, Seung-Jung Kee, Yong-Wook Park   +14 more
doaj   +3 more sources

Plasmacytoid dendritic cells cross-prime naive CD8 T cells by transferring antigen to conventional dendritic cells through exosomes

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Whether and how pDCs cross-prime CD8 T cells in vivo remain controversial despite extensive studies. Using a vaccine model where antigens were only delivered to pDCs, this report demonstrated that pDCs induced cross-priming and durable CD8 T
Aimin Jiang
exaly   +2 more sources

Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis

Journal of Experimental Medicine, 2020
Type 1 conventional dendritic cells are progressively and systemically dysregulated during pancreatic carcinogenesis, subject to semimaturation and IL-6–driven apoptosis.
David Feldser, Gregory Beatty, Erica Carpenter   +2 more
exaly   +2 more sources

Glutamine is critical for the maintenance of type 1 conventional dendritic cells in normal tissue and the tumor microenvironment. [PDF]

Proc Natl Acad Sci U S A
Significance Immune evasion is a key hallmark of cancer; however, the underlying pathways are diverse, tumor-specific, and not fully elucidated. Many tumor cells avidly import glutamine to support their anabolic needs, creating a glutamine-deficient ...
Lobel GP, Han N, Molina Arocho WA, Silber M, Shoush J, Noji MC, To TKJ, Zhai L, Lesner NP, Simon MC, Haldar M.   +10 more
europepmc   +2 more sources