Results 1 to 10 of about 130,992 (116)

Development and function of chicken XCR1+ conventional dendritic cells [PDF]

Frontiers in Immunology, 2023
Conventional dendritic cells (cDCs) are antigen-presenting cells (APCs) that play a central role in linking innate and adaptive immunity. cDCs have been well described in a number of different mammalian species, but remain poorly characterised in the ...
Zhiguang Wu, Barbara Shih, Barbara Shih, Joni Macdonald, Dominique Meunier, Kris Hogan, Cosmin Chintoan-Uta, Hazel Gilhooley, Tuanjun Hu, Mariana Beltran, Neil C. Henderson, Neil C. Henderson, Helen M. Sang, Mark P. Stevens, Michael J. McGrew, Adam Balic, Adam Balic   +16 more
doaj   +2 more sources

GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2

Frontiers in Immunology, 2023
Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy.
Seyed Mohammad Lellahi, Seyed Mohammad Lellahi, Waqas Azeem, Waqas Azeem, Waqas Azeem, Yaping Hua, Yaping Hua, Benjamin Gabriel, Benjamin Gabriel, Kristin Paulsen Rye, Håkon Reikvam, Håkon Reikvam, Karl-Henning Kalland, Karl-Henning Kalland, Karl-Henning Kalland   +14 more
doaj   +3 more sources

Type 1 conventional dendritic cells regulate innate immunity during fungal pneumonia [PDF]

mBio
Aspergillus fumigatus is a ubiquitous mold that is the primary etiological agent of invasive pulmonary aspergillosis (IPA), a severe lung infection in immunocompromised patients with extreme mortality.
Pari M. Dhruva, Thomas E. Draper, Camille A. Chiller, MaryJane Jones, Chad Steele   +4 more
doaj   +2 more sources

Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells

Pharmaceutics, 2020
Throughout the last decades, dendritic cell (DC)-based anti-tumor vaccines have proven to be a safe therapeutic approach, although with inconsistent clinical results. The functional limitations of ex vivo monocyte-derived dendritic cells (MoDCs) commonly
João Calmeiro, Mylène A. Carrascal, Adriana Ramos Tavares, Daniel Alexandre Ferreira, Célia Gomes, Amílcar Falcão, Maria Teresa Cruz, Bruno Miguel Neves   +7 more
doaj   +3 more sources

Regulation of the Migration of Distinct Dendritic Cell Subsets

Frontiers in Cell and Developmental Biology, 2021
Dendritic cells (DCs), a class of antigen-presenting cells, are widely present in tissues and apparatuses of the body, and their ability to migrate is key for the initiation of immune activation and tolerogenic immune responses.
Meng Feng, Shuping Zhou, Yong Yu, Qinghong Su, Xiaofan Li, Wei Lin   +5 more
doaj   +1 more source

OVA-PEG-R848 nanocapsules stimulate neonatal conventional and plasmacytoid dendritic cells

Frontiers in Pediatrics, 2022
Childhood mortality represents a major issue with 5. 3 million worldwide deaths of children under 5 years of age in 2019. Approximately half of those deaths can be attributed to easily preventable, infectious diseases.
Sebastian Wirsching, Marina Machtakova, Frauke Borgans, Frauke Borgans, Leah Pretsch, Michael Fichter, Michael Fichter, Michael Fichter, Maximiliano L. Cacicedo, Héloïse Thérien-Aubin, Héloïse Thérien-Aubin, Katharina Landfester, Stephan Gehring   +12 more
doaj   +1 more source

Circulating Plasmacytoid and Conventional Dendritic Cells Are Numerically and Functionally Deficient in Patients With Scrub Typhus

Frontiers in Immunology, 2021
BackgroundDendritic cells (DCs) are specialized antigen-presenting cells known to bridge innate and adaptive immune reactions. However, the relationship between circulating DCs and Orientia tsutsugamushi infection is unclear.
Seung-Ji Kang, Ki-Jeong Park, Hye-Mi Jin, Young-Nan Cho, Tae Hoon Oh, Seong Eun Kim, Uh Jin Kim, Kyung-Hwa Park, Sook-In Jung, Tae-Ok Kim, Hyo Shin Kim, Young-Goun Jo, Jae Kyun Ju, Seung-Jung Kee, Yong-Wook Park   +14 more
doaj   +1 more source

Human Dendritic Cell Subset Isolation by Magnetic Bead Sorting: A Protocol to Efficiently Obtain Pure Populations

Bio-Protocol, 2023
Dendritic cells have been investigated for cell-based immunotherapy for various applications. The low abundance of dendritic cells in blood hampers their clinical application, resulting in the use of monocyte-derived dendritic cells as an alternative ...
Georgina Flórez-Grau, Jorge Cuenca Escalona, Helena Lacasta-Mambo, Daphne Roelofs, Johanna Bödder, Ruben Beuk, Gerty Schreibelt, I Jolanda de Vries   +7 more
doaj   +1 more source

Intratumoral Combinatorial Administration of CD1c (BDCA-1)⁺ Myeloid Dendritic Cells Plus Ipilimumab and Avelumab in Combination with Intravenous Low-Dose Nivolumab in Patients with Advanced Solid Tumors: A Phase IB Clinical Trial

Vaccines, 2020
Intratumoral (IT) myeloid dendritic cells (myDCs) play a pivotal role in re-licensing antitumor cytotoxic T lymphocytes. IT injection of the IgG1 monoclonal antibodies ipilimumab and avelumab may induce antibody-dependent cellular cytotoxicity, thereby ...
Julia Katharina Schwarze, Gil Awada, Louise Cras, Jens Tijtgat, Ramses Forsyth, Inès Dufait, Sandra Tuyaerts, Ivan Van Riet, Bart Neyns   +8 more
doaj   +1 more source

Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis

Frontiers in Immunology, 2022
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions.
Izumi Sasaki, Takashi Kato, Hiroaki Hemmi, Hiroaki Hemmi, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Asumi Yamamoto, Tsuneyasu Kaisho   +7 more
doaj   +1 more source