Results 11 to 20 of about 6,856,628 (321)

The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity [PDF]

Trends in Cancer, 2018
Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection ...
Caetano Reis E Sousa, Jan Böttcher
exaly   +4 more sources

Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses [PDF]

Frontiers in Immunology, 2019
Dendritic cells (DCs) facilitate cross talk between the innate and adaptive immune system. They sense and phagocytose invading pathogens, and are not only capable of activating naïve T cells, but can also determine the polarization of T cell responses ...
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Arnar Gudjonsson, Arnar Gudjonsson, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +8 more
doaj   +6 more sources

Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells [PDF]

Pharmaceutics, 2020
Throughout the last decades, dendritic cell (DC)-based anti-tumor vaccines have proven to be a safe therapeutic approach, although with inconsistent clinical results. The functional limitations of ex vivo monocyte-derived dendritic cells (MoDCs) commonly
João Calmeiro, Mylène A. Carrascal, Adriana Ramos Tavares, Daniel Alexandre Ferreira, Célia Gomes, Amílcar Falcão, Maria Teresa Cruz, Bruno Miguel Neves   +7 more
doaj   +6 more sources

Conventional type 1 dendritic cells (cDC1) in cancer immunity

Biology Direct, 2023
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses.
Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp   +3 more
doaj   +5 more sources

Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo [PDF]

Frontiers in Immunology, 2018
Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Johanna Salvermoser, Johanna Salvermoser, Janneke van Blijswijk, Nikos E. Papaioannou, Stephan Rambichler, Stephan Rambichler, Maria Pasztoi, Dalia Pakalniškytė, Dalia Pakalniškytė, Neil C. Rogers, Selina J. Keppler, Tobias Straub, Tobias Straub, Caetano Reis e Sousa, Barbara U. Schraml, Barbara U. Schraml   +15 more
doaj   +6 more sources

Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity [PDF]

The Journal of Immunology, 2020
Key Points Merocytic dendritic cells (mcDCs) express ZBTB46 and originate from pre-cDCs. mcDCs are dependent on IRF-4 and express a unique gene signature. mcDCs exhibit a different metabolic phenotype relative to other DC subsets.
Cindy Audiger, Adrien Fois, Alyssa L. Thomas, Edith M. Janssen, Martin Pelletier, S. Lesage   +5 more
semanticscholar   +3 more sources

Structural and functional convergence and divergence of myeloid dendritic cells and conventional dendritic cells

Sokoto Journal of Medical Laboratory Science
Dendritic cells (DCs) are essential regulators of immune responses, acting as a bridge between innate and adaptive immunity. They play a critical role in recognizing and responding to microbial threats and malignant transformations, ensuring appropriate ...
Jonathan Joshua Danjuma, Hayatu Saidu
semanticscholar   +3 more sources

Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis

Frontiers in Immunology, 2022
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions.
Izumi Sasaki, Takashi Kato, Hiroaki Hemmi, Hiroaki Hemmi, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Asumi Yamamoto, Tsuneyasu Kaisho   +7 more
doaj   +3 more sources

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis

Frontiers in Immunology, 2018
ObjectiveDendritic cells (DCs) are key orchestrators of immune function. To date, rheumatoid arthritis (RA) researchers have predominantly focused on a potential pathogenic role for CD1c+ DCs.
Faye A. H. Cooles, Faye A. H. Cooles, Amy E. Anderson, Amy E. Anderson, Andrew Skelton, Andrew Skelton, Arthur G. Pratt, Arthur G. Pratt, Mariola S. Kurowska-Stolarska, Mariola S. Kurowska-Stolarska, Iain McInnes, Iain McInnes, Catharien M. U. Hilkens, Catharien M. U. Hilkens, John D. Isaacs, John D. Isaacs   +15 more
doaj   +3 more sources

Conventional Dendritic Cells and Slan+ Monocytes During HIV-2 Infection [PDF]

Frontiers in Immunology, 2020
HIV-2 infection is characterized by low viremia and slow disease progression as compared to HIV-1 infection. Circulating CD14++CD16+ monocytes were found to accumulate and CD11c+ conventional dendritic cells (cDC) to be depleted in a Portuguese cohort of
Marco Iannetta, Stéphane Isnard, Jennifer Manuzak, Jean-Baptiste Guillerme, Mathilde Notin, Karine Bailly, Muriel Andrieu, Sonia Amraoui, Lene Vimeux, Suzanne Figueiredo, Bénédicte Charmeteau-de Muylder, Laura Vaton, Etienne X. Hatton, Assia Samri, Brigitte Autran, Rodolphe Thiébaut, Nathalie Chaghil, David Glohi, Charlotte Charpentier, Diane Descamps, Françoise Brun-Vézinet, Sophie Matheron, Sophie Matheron, Remi Cheynier, Anne Hosmalin   +24 more
doaj   +4 more sources