Results 11 to 20 of about 121,661 (250)

Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses [PDF]

Frontiers in Immunology, 2019
Dendritic cells (DCs) facilitate cross talk between the innate and adaptive immune system. They sense and phagocytose invading pathogens, and are not only capable of activating naïve T cells, but can also determine the polarization of T cell responses ...
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Arnar Gudjonsson, Arnar Gudjonsson, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +8 more
doaj   +5 more sources

Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis

Frontiers in Immunology, 2022
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions.
Izumi Sasaki, Takashi Kato, Hiroaki Hemmi, Hiroaki Hemmi, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Asumi Yamamoto, Tsuneyasu Kaisho   +7 more
doaj   +3 more sources

Conventional type 1 dendritic cells (cDC1) in cancer immunity

Biology Direct, 2023
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses.
Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp   +3 more
doaj   +4 more sources

Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo [PDF]

Frontiers in Immunology, 2018
Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Johanna Salvermoser, Johanna Salvermoser, Janneke van Blijswijk, Nikos E. Papaioannou, Stephan Rambichler, Stephan Rambichler, Maria Pasztoi, Dalia Pakalniškytė, Dalia Pakalniškytė, Neil C. Rogers, Selina J. Keppler, Tobias Straub, Tobias Straub, Caetano Reis e Sousa, Barbara U. Schraml, Barbara U. Schraml   +15 more
doaj   +5 more sources

Conventional Dendritic Cells and Slan+ Monocytes During HIV-2 Infection [PDF]

Frontiers in Immunology, 2020
HIV-2 infection is characterized by low viremia and slow disease progression as compared to HIV-1 infection. Circulating CD14++CD16+ monocytes were found to accumulate and CD11c+ conventional dendritic cells (cDC) to be depleted in a Portuguese cohort of
Marco Iannetta, Stéphane Isnard, Jennifer Manuzak, Jean-Baptiste Guillerme, Mathilde Notin, Karine Bailly, Muriel Andrieu, Sonia Amraoui, Lene Vimeux, Suzanne Figueiredo, Bénédicte Charmeteau-de Muylder, Laura Vaton, Etienne X. Hatton, Assia Samri, Brigitte Autran, Rodolphe Thiébaut, Nathalie Chaghil, David Glohi, Charlotte Charpentier, Diane Descamps, Françoise Brun-Vézinet, Sophie Matheron, Sophie Matheron, Remi Cheynier, Anne Hosmalin   +24 more
doaj   +4 more sources

STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation [PDF]

iScience, 2020
Summary: Signaling through stimulator of interferon genes (STING) leads to the production of type I interferons (IFN-Is) and inflammatory cytokines. A gain-of-function mutation in STING was identified in an autoinflammatory disease (STING-associated ...
Arthid Thim-uam, Thaneas Prabakaran, Mookmanee Tansakul, Jiradej Makjaroen, Piriya Wongkongkathep, Naphat Chantaravisoot, Thammakorn Saethang, Asada Leelahavanichkul, Thitima Benjachat, Søren Paludan, Trairak Pisitkun, Prapaporn Pisitkun   +11 more
doaj   +6 more sources

mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells [PDF]

Frontiers in Immunology, 2019
In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved.
Alicia R. Watson, Alicia R. Watson, Helong Dai, Helong Dai, Yawen Zheng, Yawen Zheng, Ryosuke Nakano, Anastasios D. Giannou, Ashley V. Menk, Donna B. Stolz, Greg M. Delgoffe, Greg M. Delgoffe, Angus W. Thomson, Angus W. Thomson   +13 more
doaj   +3 more sources

Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity [PDF]

The Journal of Immunology, 2020
Abstract Conventional dendritic cells (cDCs) are arguably the most potent APCs that induce the activation of naive T cells in response to pathogens. In addition, at steady-state, cDCs help maintain immune tolerance. Two subsets of cDCs have been extensively characterized, namely cDC1 and cDC2, each contributing differently to immune ...
Cindy Audiger, Adrien Fois, Alyssa L Thomas, Edith Janssen, Martin Pelletier, Sylvie Lesage   +5 more
openaire   +2 more sources

Role of conventional dendritic cells in schistosomiasis-induced pulmonary hypertension. [PDF]

Clin Sci (Lond)
Background: Schistosomiasis is a major cause of pulmonary hypertension (PH) worldwide, and CD4 T cells are critical in disease pathogenesis. The role of dendritic cells (DCs) in Schistosoma-induced PH (SchPH) is unknown. There are two types of conventional DCs, cDC1 and cDC2, that prototypically activate CD8 and CD4 T cells, respectively.
Mickael C, Kumar R, Fonseca Balladares DC, Nolan K, Lee MH, Kassa B, Menezes TCF, Lau-Xiao A, Sahota A, Sanders L, Tuscan K, Gandjeva A, Cautivo KM, Molofsky A, Graham BB.   +14 more
europepmc   +3 more sources

Circulating Plasmacytoid and Conventional Dendritic Cells Are Numerically and Functionally Deficient in Patients With Scrub Typhus

Frontiers in Immunology, 2021
BackgroundDendritic cells (DCs) are specialized antigen-presenting cells known to bridge innate and adaptive immune reactions. However, the relationship between circulating DCs and Orientia tsutsugamushi infection is unclear.
Seung-Ji Kang, Ki-Jeong Park, Hye-Mi Jin, Young-Nan Cho, Tae Hoon Oh, Seong Eun Kim, Uh Jin Kim, Kyung-Hwa Park, Sook-In Jung, Tae-Ok Kim, Hyo Shin Kim, Young-Goun Jo, Jae Kyun Ju, Seung-Jung Kee, Yong-Wook Park   +14 more
doaj   +1 more source