Results 1 to 10 of about 29,264 (228)

Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo [PDF]

BMC Cancer, 2008
Background Gliomas are the most common and aggressive primary brain tumors for which unfortunately no effective treatment modalities exist despite advances in molecular biology as the knowledge base to unravel the extremely complex molecular mechanisms ...
Wang Ai-Dong, Zhai De-Zhong, Dong Jun, Huang Qiang, Chen Hua, Lan Qing   +5 more
doaj   +6 more sources

Plasmodium yoelii infection induces lung injury by modulating type 2 conventional dendritic cells autophagy via the STAT3-IRF4 signaling [PDF]

Cell Death and Disease
Malaria is an infectious disease caused by Plasmodium that severely impacts human health, often resulting in lung injury. Classical type 2 dendritic cells (cDC2) in the lungs play a crucial role in the pathogenesis of asthma and infectious diseases ...
Cansheng Hong, Guorong Deng, Zhihan Jiang, Yishuai Lu, Qianlian Wu, Chao Huang, Jia Tang, Haiqi Zhou, Qinan Liu, Xiujuan Luo, Yi Zhao, Yanwei Qi, Qingqing Li, Xiancai Ma, Quan Yang   +14 more
doaj   +2 more sources

Single-cell transcriptomic analysis deciphers heterogeneity and transcriptional regulatory programs of sepsis with different prognosis [PDF]

Biology Direct
Sepsis has a high mortality rate, yet the cellular heterogeneity and transcriptional regulatory programs associated with divergent clinical outcomes remain incompletely understood.
Yuanming Yang, Yiwei Hua, Suyi Yang, Nan Liu, Jun Li   +4 more
doaj   +2 more sources

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection. [PDF]

Adv Sci (Weinh)
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Meurisse F, Coindre S, Wijkhuisen A, Marlin R, Fournier Le Ray L, Pons J, Yaugel-Novoa M, Avettand-Fenoel V, Abi-Rached L, Gallouet AS, Relouzat F, Gourves M, Saez-Cirion A, Arase H, Zurawski G, Zurawski S, Dereuddre-Bosquet N, Le Grand R, Simon S, Lambotte O, Favier B.   +20 more
europepmc   +2 more sources

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45 [PDF]

Oncogene, 1999
Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV radiation and alkylating agents. While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been found to directly inhibit the ...
Albert J Fornace, Xin Wei Wang, France Carrier   +2 more
exaly   +3 more sources

Raptor is phosphorylated by cdc2 during mitosis. [PDF]

PLoS ONE, 2010
The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division.
Dana M Gwinn, John M Asara, Reuben J Shaw   +2 more
doaj   +6 more sources

Unraveling porcine dendritic-cell diversity: welcome tDC and DC3 [PDF]

Frontiers in Immunology
Dendritic cells (DC) are professional antigen presenting cells playing a major role in orchestrating adaptative immune responses. To adapt to various immune challenges, such as different classes of pathogens, specialized subsets of DC have evolved across
Ambre Baillou, Ambre Baillou, Gaël Auray, Gaël Auray, Francisco Brito, Francisco Brito, Marius Botos, Marius Botos, Alizée Huber, Alizée Huber, Artur Summerfield, Artur Summerfield, Stephanie C. Talker, Stephanie C. Talker   +13 more
doaj   +2 more sources

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe [PDF]

Open Biology, 2011
Target of rapamycin complexes (TORCs), which are vital for nutrient utilization, contain a catalytic subunit with the phosphatidyl inositol kinase-related kinase (PIKK) motif.
Nobuyasu Ikai, Norihiko Nakazawa, Takeshi Hayashi, Mitsuhiro Yanagida   +3 more
doaj   +1 more source

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

iScience, 2021
Summary: Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated ...
Samuel W. Lukowski, Inga Rødahl, Samuel Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle Belz, Ian H. Frazer, Janin Chandra   +11 more
doaj   +1 more source

Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis [PDF]

Open Biology, 2014
Analogue-sensitive (as) mutants of kinases are widely used to selectively inhibit a single kinase with few off-target effects. The analogue-sensitive mutant cdc2-as of fission yeast (Schizosaccharomyces pombe) is a powerful tool to study the cell cycle ...
Yuki Aoi, Shigehiro A. Kawashima, Viesturs Simanis, Masayuki Yamamoto, Masamitsu Sato   +4 more
doaj   +1 more source