Results 1 to 10 of about 29,622 (230)

Plasmodium yoelii infection induces lung injury by modulating type 2 conventional dendritic cells autophagy via the STAT3-IRF4 signaling [PDF]

Cell Death and Disease
Malaria is an infectious disease caused by Plasmodium that severely impacts human health, often resulting in lung injury. Classical type 2 dendritic cells (cDC2) in the lungs play a crucial role in the pathogenesis of asthma and infectious diseases ...
Cansheng Hong, Guorong Deng, Zhihan Jiang, Yishuai Lu, Qianlian Wu, Chao Huang, Jia Tang, Haiqi Zhou, Qinan Liu, Xiujuan Luo, Yi Zhao, Yanwei Qi, Qingqing Li, Xiancai Ma, Quan Yang   +14 more
doaj   +2 more sources

Single-cell transcriptomic analysis deciphers heterogeneity and transcriptional regulatory programs of sepsis with different prognosis [PDF]

Biology Direct
Sepsis has a high mortality rate, yet the cellular heterogeneity and transcriptional regulatory programs associated with divergent clinical outcomes remain incompletely understood.
Yuanming Yang, Yiwei Hua, Suyi Yang, Nan Liu, Jun Li   +4 more
doaj   +2 more sources

Identification of heterogeneous subtypes of human dendritic cells from the lymph nodes of patients with gastric cancer [PDF]

Frontiers in Immunology
ObjectiveThe subtypes of heterogeneous conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) in lymph nodes (LN) cannot be distinguished because they share similar surface markers.
Song-Hee Han, In-Jeong Lee, Hue Vy An Tran, Mi Ha Joo, Kwan Woo Kim, JungMo Kim, Seung Ho Kim, Hyun Goo Woo, Hyun Goo Woo, Min Chan Kim, Jong-Young Kwak   +10 more
doaj   +2 more sources

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe [PDF]

Open Biology, 2011
Target of rapamycin complexes (TORCs), which are vital for nutrient utilization, contain a catalytic subunit with the phosphatidyl inositol kinase-related kinase (PIKK) motif.
Nobuyasu Ikai, Norihiko Nakazawa, Takeshi Hayashi, Mitsuhiro Yanagida   +3 more
doaj   +1 more source

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

iScience, 2021
Summary: Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated ...
Samuel W. Lukowski, Inga Rødahl, Samuel Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle Belz, Ian H. Frazer, Janin Chandra   +11 more
doaj   +1 more source

Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis [PDF]

Open Biology, 2014
Analogue-sensitive (as) mutants of kinases are widely used to selectively inhibit a single kinase with few off-target effects. The analogue-sensitive mutant cdc2-as of fission yeast (Schizosaccharomyces pombe) is a powerful tool to study the cell cycle ...
Yuki Aoi, Shigehiro A. Kawashima, Viesturs Simanis, Masayuki Yamamoto, Masamitsu Sato   +4 more
doaj   +1 more source

Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung

Allergology International, 2021
Background: Follicular helper T (Tfh) cells represent a unique subset of helper CD4+ T cells in lymphoid follicles. Recently, Tfh cells were shown to play an important role in asthma through B cell differentiation.
Shogo Sakurai, Kazuki Furuhashi, Ryo Horiguchi, Fumiya Nihashi, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda   +12 more
doaj   +1 more source

Communication between Cyclin-dependent kinase Cdc2 and the Wis1-Spc1 MAPK pathway determines mitotic timing in Schizosaccharomyces pombe

Biology Open, 2020
Checkpoint activation and gene expression modulation represent key determinants of cellular survival in adverse conditions. The former is regulated by cyclin-dependent kinases (CDKs) while the latter can be controlled by mitogen-activated protein kinases
Agamani Ghosal, Priyanka Sarkar, Geetanjali Sundaram   +2 more
doaj   +1 more source

STAT3 signaling modulates the immune response induced after antigen targeting to conventional type 1 dendritic cells through the DEC205 receptor

Frontiers in Immunology, 2022
Conventional dendritic cells (cDC) are a group of antigen-presenting cells specialized in priming T cell responses. In mice, splenic cDC are divided into conventional type 1 DC (cDC1) and conventional type 2 (cDC2).
Fernando Bandeira Sulczewski, Larissa Alves Martino, Davi Salles, Márcio Massao Yamamoto, Daniela Santoro Rosa, Daniela Santoro Rosa, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin   +7 more
doaj   +1 more source

Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]

PLoS ONE, 2011
During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi, Masayuki Fukui, Bao Ting Zhu   +2 more
doaj   +1 more source