Results 31 to 40 of about 29,622 (230)

GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2

Frontiers in Immunology, 2023
Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy.
Seyed Mohammad Lellahi, Seyed Mohammad Lellahi, Waqas Azeem, Waqas Azeem, Waqas Azeem, Yaping Hua, Yaping Hua, Benjamin Gabriel, Benjamin Gabriel, Kristin Paulsen Rye, Håkon Reikvam, Håkon Reikvam, Karl-Henning Kalland, Karl-Henning Kalland, Karl-Henning Kalland   +14 more
doaj   +1 more source

Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin

Frontiers in Immunology, 2018
Systemic immunization with soluble flagellin (sFliC) from Salmonella Typhimurium induces mucosal responses, offering potential as an adjuvant platform for vaccines. Moreover, this engagement of mucosal immunity is necessary for optimal systemic immunity,
Adriana Flores-Langarica, Charlotte Cook, Katarzyna Müller Luda, Emma K. Persson, Jennifer L. Marshall, Nonantzin Beristain-Covarrubias, Juan Carlos Yam-Puc, Madelene Dahlgren, Jenny J. Persson, Satoshi Uematsu, Satoshi Uematsu, Shizuo Akira, Ian R. Henderson, Bengt Johansson Lindbom, Bengt Johansson Lindbom, William Agace, William Agace, Adam F. Cunningham   +17 more
doaj   +1 more source

CD163+ cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer

Journal for ImmunoTherapy of Cancer, 2020
Background Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct clinical entity with a much better prognosis after (chemo)radiotherapy than HPV-negative OPSCC, especially in patients with a concomitant ...
Sjoerd H van der Burg, Ilina Ehsan, Ekaterina J Jordanova, Florent Ginhoux, Saskia J Santegoets, Chantal L Duurland, Nikki M Loof, Sylvia L van Egmond, Vanessa J van Ham, Vipin Narang, Charles A Dutertre, Marij J P Welters   +11 more
doaj   +1 more source

Cdc2: a monopotent or pluripotent CDK? [PDF]

Cell Proliferation, 2011
Cell cycle progression is controlled by both extracellular and intracellular signalling molecules. It has been generally believed that cdc2/CDK1 only control G(2)-M transition in mammalian and many other higher eukaryotic cells. Accumulating evidence shows that cdc2 not only promotes G(2)-M transition but is also capable of regulating G(1) progress and
X, Hu, L C, Moscinski
openaire   +2 more sources

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

Differential Regulation of Cdc2 and Cdk2 by RINGO and Cyclins [PDF]

Journal of Biological Chemistry, 2001
Cyclin-dependent kinases (Cdks) are key regulators of the eukaryotic cell division cycle. Cdk1 (Cdc2) and Cdk2 should be bound to regulatory subunits named cyclins as well as phosphorylated on a conserved Thr located in the T-loop for full enzymatic activity.
Karaiskou, A., Perez, L.H., Ferby, I., Ozon, René, Jessus, Catherine, Nebreda, A.R.   +5 more
openaire   +4 more sources

cdc2 phosphorylation is required for its interaction with cyclin. [PDF]

The EMBO Journal, 1991
Activation of the cdc2 protein kinase at different stages of the cell cycle is regulated by post-translational modifications and interactions with cyclins. We show that in vitro translated human cdc2 binds very poorly to A and B cyclins, unless it has been preincubated with a Xenopus egg extract. This results in the phosphorylation of cdc2 which allows
Ducommun, B, BRAMBILLA, PAOLO, Félix, M, Franza, B, Karsenti, E, Draetta, G.   +5 more
openaire   +4 more sources

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

eLife, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent infection. With advancing age the
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman   +14 more
doaj   +1 more source

CDC2 Activation Is Not Required for Thymocyte Apoptosis

Biochemical and Biophysical Research Communications, 1994
Apoptosis is a mode of cell death characterized by chromatin condensation and disassembly of the nuclear lamina, processes that are also characteristic of mitosis. The apparent similarity between the two events, together with observations that apoptosis can occur following G2 arrest, has led to the suggestion that apoptosis could be a defective form of
Norbury, C, MacFarlane, M, Fearnhead, H, Cohen, G   +3 more
openaire   +3 more sources

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. [PDF]

Proceedings of the National Academy of Sciences, 1992
Recent studies have shown that there exists a family of protein kinases structurally and functionally related to the yeast cell cycle regulatory kinase cdc2 [Meyerson, M., Faha, B., Su, L.-K., Harlow, E. & Tsai, L.-H. (1991) Cold Spring Harbor Symp. Quant. Biol. 56, 177-186 and Meyerson, M., Enders, G. H., Wu, C.-L., Su, L.-K., Gorka, C., Nelson, C.
M R, Hellmich, H C, Pant, E, Wada, J F, Battey   +3 more
openaire   +2 more sources