Results 31 to 40 of about 29,264 (228)

Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes

Cell Reports, 2023
Summary: The current paradigm indicates that naive T cells are primed in secondary lymphoid organs. Here, we present evidence that intranasal administration of peptide antigens appended to nanofibers primes naive CD8+ T cells in the lung independently ...
Youhui Si, Yihan Wang, Qiaomu Tian, Qiang Wang, Jared M. Pollard, Pramod K. Srivastava, Aaron P. Esser-Kahn, Joel H. Collier, Anne I. Sperling, Anita S. Chong   +9 more
doaj   +1 more source

Characterization of the Murine cdc2 Gene

Molecules and Cells, 1998
A 1204 bp full-length cDNA encoding murine cdc2 was isolated and used as a probe to obtain four overlapping cdc2 genomic clones which span the entire cdc2 sequence. Characterization of these clones revealed that the cdc2 mRNA is distributed over 28 kb and in 8 exons ranging in size from 63 to approximately 303 bp.
D, Jun, H K, Park, A A, Nordin, J E, Nagel, Y H, Kim   +4 more
openaire   +2 more sources

Differential Effects of Anti-TNFα and Anti-α4β7 Drugs on Circulating Dendritic Cells Migratory Capacity in Inflammatory Bowel Disease

Biomedicines, 2022
Inflammatory bowel disease (IBD) is an idiopathic and chronic disorder that includes ulcerative colitis (UC) and Crohn’s disease (CD). Both diseases show an uncontrolled intestinal immune response that generates tissue inflammation. Dendritic cells (DCs)
Irene Soleto, Samuel Fernández-Tomé, Irene Mora-Gutiérrez, Montserrat Baldan-Martin, Cristina Ramírez, Cecilio Santander, José Andrés Moreno-Monteagudo, María José Casanova, Fernando Casals, Sergio Casabona, Irene Becerro, María Chaparro, David Bernardo, Javier P. Gisbert   +13 more
doaj   +1 more source

High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a [PDF]

, 2012
The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry.
Engels, Kristin K., Marhofer, Richard J., Bender, Frank, Mottram, Jeremy C., Gassel, Michael, Selzer, Paul M., Fernandez, Maria L. Suarez   +6 more
core   +1 more source

GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2

Frontiers in Immunology, 2023
Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy.
Seyed Mohammad Lellahi, Seyed Mohammad Lellahi, Waqas Azeem, Waqas Azeem, Waqas Azeem, Yaping Hua, Yaping Hua, Benjamin Gabriel, Benjamin Gabriel, Kristin Paulsen Rye, Håkon Reikvam, Håkon Reikvam, Karl-Henning Kalland, Karl-Henning Kalland, Karl-Henning Kalland   +14 more
doaj   +1 more source

CD163+ cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer

Journal for ImmunoTherapy of Cancer, 2020
Background Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct clinical entity with a much better prognosis after (chemo)radiotherapy than HPV-negative OPSCC, especially in patients with a concomitant ...
Sjoerd H van der Burg, Ilina Ehsan, Ekaterina J Jordanova, Florent Ginhoux, Saskia J Santegoets, Chantal L Duurland, Nikki M Loof, Sylvia L van Egmond, Vanessa J van Ham, Vipin Narang, Charles A Dutertre, Marij J P Welters   +11 more
doaj   +1 more source

Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin

Frontiers in Immunology, 2018
Systemic immunization with soluble flagellin (sFliC) from Salmonella Typhimurium induces mucosal responses, offering potential as an adjuvant platform for vaccines. Moreover, this engagement of mucosal immunity is necessary for optimal systemic immunity,
Adriana Flores-Langarica, Charlotte Cook, Katarzyna Müller Luda, Emma K. Persson, Jennifer L. Marshall, Nonantzin Beristain-Covarrubias, Juan Carlos Yam-Puc, Madelene Dahlgren, Jenny J. Persson, Satoshi Uematsu, Satoshi Uematsu, Shizuo Akira, Ian R. Henderson, Bengt Johansson Lindbom, Bengt Johansson Lindbom, William Agace, William Agace, Adam F. Cunningham   +17 more
doaj   +1 more source

Cdc2: a monopotent or pluripotent CDK? [PDF]

Cell Proliferation, 2011
Cell cycle progression is controlled by both extracellular and intracellular signalling molecules. It has been generally believed that cdc2/CDK1 only control G(2)-M transition in mammalian and many other higher eukaryotic cells. Accumulating evidence shows that cdc2 not only promotes G(2)-M transition but is also capable of regulating G(1) progress and
X, Hu, L C, Moscinski
openaire   +2 more sources

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

Differential Regulation of Cdc2 and Cdk2 by RINGO and Cyclins [PDF]

Journal of Biological Chemistry, 2001
Cyclin-dependent kinases (Cdks) are key regulators of the eukaryotic cell division cycle. Cdk1 (Cdc2) and Cdk2 should be bound to regulatory subunits named cyclins as well as phosphorylated on a conserved Thr located in the T-loop for full enzymatic activity.
Karaiskou, A., Perez, L.H., Ferby, I., Ozon, René, Jessus, Catherine, Nebreda, A.R.   +5 more
openaire   +4 more sources