Results 21 to 30 of about 29,622 (230)

TIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3

Cell Death and Disease, 2023
The outcome of the disease visceral leishmaniasis (VL), caused by Leishmania donovani (LD), largely relies on the relative dominance of host-protective type-1 T helper (Th1) cell response versus disease-promoting type-2 T helper (Th2) cell response.
Manish Mishra, Manisha Yadav, Sandeep Kumar, Raj Kumar, Pradip Sen   +4 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection. [PDF]

Adv Sci (Weinh)
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Meurisse F, Coindre S, Wijkhuisen A, Marlin R, Fournier Le Ray L, Pons J, Yaugel-Novoa M, Avettand-Fenoel V, Abi-Rached L, Gallouet AS, Relouzat F, Gourves M, Saez-Cirion A, Arase H, Zurawski G, Zurawski S, Dereuddre-Bosquet N, Le Grand R, Simon S, Lambotte O, Favier B.   +20 more
europepmc   +2 more sources

تأثیر 6 هفته تمرین بر روی نوار گردان به همراه مصرف جنیستئین بر بیان ژن iNOS و Cdc2 در موش های بالب سی مبتلا به سرطان پستان [PDF]

Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.
مقدمه: هدف پژوهش بررسی تاثیر 6 هفته تمرین بر روی نوار گردان به همراه مصرف جنیستئین بر بیان ژن iNOS و Cdc2 در موش های بالب سی مبتلا به سرطان پستان بود.روش کار:  در این مطالعه بنیادی، تجربی که روی 40 سر موش ماده Balb/C انجام شد، بعد از القاء سرطان پستان ...
سیده زهرا حاجی آقایی, ساناز میرزایان شانجانی, زهره افشارمند, یاسر کاظم زاده   +3 more
doaj   +1 more source

Interaction of Type 1 Porcine Reproductive and Respiratory Syndrome Virus With In Vitro Derived Conventional Dendritic Cells

Frontiers in Immunology, 2021
The present study delineates the interaction of a typical PRRSV1.1 isolate 3267 (moderate virulence) with in vitro derived pig conventional dendritic cells, cDC1, cDC2, and a CD14+ population (designated as CD14+ DCs).
Yanli Li, Enric Mateu, Enric Mateu
doaj   +1 more source

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase. [PDF]

The EMBO Journal, 1992
Exit from metaphase of the cell cycle requires inactivation of MPF, a stoichiometric complex between the cdc2 catalytic and the cyclin B regulatory subunits, as well as that of cyclin A-cdc2 kinase. Inactivation of both complexes depends on proteolytic degradation of the cyclin subunit, yet cyclin proteolysis is not sufficient to inactivate the H1 ...
T, Lorca, J C, Labbé, A, Devault, D, Fesquet, J P, Capony, J C, Cavadore, F, Le Bouffant, M, Dorée   +7 more
openaire   +2 more sources

Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. [PDF]

PLoS ONE, 2015
The activity of Cdc2 (CDK1) kinase, which coordinates cell cycle progression and DNA break repair, is blocked upon its phosphorylation at tyrosine 15 (Y15) by Wee1 kinase in the presence of DNA damage.
Thomas Caspari, Victoria Hilditch
doaj   +1 more source

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Nature Communications, 2021
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear.
Nikos E. Papaioannou, Natallia Salei, Stephan Rambichler, Kaushikk Ravi, Jelena Popovic, Vanessa Küntzel, Christian H. K. Lehmann, Remi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, Denise Messerer, Joana Carrelha, Caspar Ohnmacht, Dirk Haller, Ralf Stumm, Tobias Straub, Sten Eirik W. Jacobsen, Christian Schulz, David R. Withers, Gunnar Schotta, Diana Dudziak, Barbara U. Schraml   +22 more
doaj   +1 more source

Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes

Cell Reports, 2023
Summary: The current paradigm indicates that naive T cells are primed in secondary lymphoid organs. Here, we present evidence that intranasal administration of peptide antigens appended to nanofibers primes naive CD8+ T cells in the lung independently ...
Youhui Si, Yihan Wang, Qiaomu Tian, Qiang Wang, Jared M. Pollard, Pramod K. Srivastava, Aaron P. Esser-Kahn, Joel H. Collier, Anne I. Sperling, Anita S. Chong   +9 more
doaj   +1 more source

Characterization of the Murine cdc2 Gene

Molecules and Cells, 1998
A 1204 bp full-length cDNA encoding murine cdc2 was isolated and used as a probe to obtain four overlapping cdc2 genomic clones which span the entire cdc2 sequence. Characterization of these clones revealed that the cdc2 mRNA is distributed over 28 kb and in 8 exons ranging in size from 63 to approximately 303 bp.
D, Jun, H K, Park, A A, Nordin, J E, Nagel, Y H, Kim   +4 more
openaire   +2 more sources

Differential Effects of Anti-TNFα and Anti-α4β7 Drugs on Circulating Dendritic Cells Migratory Capacity in Inflammatory Bowel Disease

Biomedicines, 2022
Inflammatory bowel disease (IBD) is an idiopathic and chronic disorder that includes ulcerative colitis (UC) and Crohn’s disease (CD). Both diseases show an uncontrolled intestinal immune response that generates tissue inflammation. Dendritic cells (DCs)
Irene Soleto, Samuel Fernández-Tomé, Irene Mora-Gutiérrez, Montserrat Baldan-Martin, Cristina Ramírez, Cecilio Santander, José Andrés Moreno-Monteagudo, María José Casanova, Fernando Casals, Sergio Casabona, Irene Becerro, María Chaparro, David Bernardo, Javier P. Gisbert   +13 more
doaj   +1 more source