Results 21 to 30 of about 29,264 (228)

Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]

PLoS ONE, 2011
During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi, Masayuki Fukui, Bao Ting Zhu   +2 more
doaj   +1 more source

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

Frontiers in Immunology, 2020
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals.
Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Xuezhi Dai, Xuezhi Dai, Diana Dudziak, David J. Rawlings, David J. Rawlings, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Pierre Guermonprez, Andrew P. Cope   +16 more
doaj   +1 more source

Saponin-based adjuvants enhance antigen cross-presentation in human CD11c+ CD1c+ CD5− CD163+ conventional type 2 dendritic cells

Journal for ImmunoTherapy of Cancer, 2023
Background Adjuvants are key for effective vaccination against cancer and chronic infectious diseases. Saponin-based adjuvants (SBAs) are unique among adjuvants in their ability to induce robust cell-mediated immune responses in addition to antibody ...
Harry Dolstra, Gosse J Adema, Nataschja I Ho, Lisa G M Huis in 't Veld, Jesper van Eck van der Sluijs, Branco M H Heuts, Maaike W G Looman, Esther D Kers-Rebel, Koen van den Dries, Joost H A Martens, Willemijn Hobo   +10 more
doaj   +1 more source

Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease [PDF]

, 2005
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD.
Prince, J. A., Blennow, Kaj,, Zetterberg, H, Hampel, Harald, Zetterberg, H., Buerger, Katharina, Zetterberg, Henrik,, Wahlund, LO, Buerger, K., Hampel, H, Blennow, K, Wahlund, Lars-Olof, Minthon, L, Blennow, K., Hampel, H., Prince, Jonathan A., Minthon, L., Buerger, K, Johansson, A., Minthon, Lennart, Johansson, Annica,, Prince, JA, Minthon, Lennart,, Johansson, A   +23 more
core   +1 more source

TIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3

Cell Death and Disease, 2023
The outcome of the disease visceral leishmaniasis (VL), caused by Leishmania donovani (LD), largely relies on the relative dominance of host-protective type-1 T helper (Th1) cell response versus disease-promoting type-2 T helper (Th2) cell response.
Manish Mishra, Manisha Yadav, Sandeep Kumar, Raj Kumar, Pradip Sen   +4 more
doaj   +1 more source

تأثیر 6 هفته تمرین بر روی نوار گردان به همراه مصرف جنیستئین بر بیان ژن iNOS و Cdc2 در موش های بالب سی مبتلا به سرطان پستان [PDF]

Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.
مقدمه: هدف پژوهش بررسی تاثیر 6 هفته تمرین بر روی نوار گردان به همراه مصرف جنیستئین بر بیان ژن iNOS و Cdc2 در موش های بالب سی مبتلا به سرطان پستان بود.روش کار:  در این مطالعه بنیادی، تجربی که روی 40 سر موش ماده Balb/C انجام شد، بعد از القاء سرطان پستان ...
سیده زهرا حاجی آقایی, ساناز میرزایان شانجانی, زهره افشارمند, یاسر کاظم زاده   +3 more
doaj   +1 more source

Interaction of Type 1 Porcine Reproductive and Respiratory Syndrome Virus With In Vitro Derived Conventional Dendritic Cells

Frontiers in Immunology, 2021
The present study delineates the interaction of a typical PRRSV1.1 isolate 3267 (moderate virulence) with in vitro derived pig conventional dendritic cells, cDC1, cDC2, and a CD14+ population (designated as CD14+ DCs).
Yanli Li, Enric Mateu, Enric Mateu
doaj   +1 more source

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase. [PDF]

The EMBO Journal, 1992
Exit from metaphase of the cell cycle requires inactivation of MPF, a stoichiometric complex between the cdc2 catalytic and the cyclin B regulatory subunits, as well as that of cyclin A-cdc2 kinase. Inactivation of both complexes depends on proteolytic degradation of the cyclin subunit, yet cyclin proteolysis is not sufficient to inactivate the H1 ...
T, Lorca, J C, Labbé, A, Devault, D, Fesquet, J P, Capony, J C, Cavadore, F, Le Bouffant, M, Dorée   +7 more
openaire   +2 more sources

Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. [PDF]

PLoS ONE, 2015
The activity of Cdc2 (CDK1) kinase, which coordinates cell cycle progression and DNA break repair, is blocked upon its phosphorylation at tyrosine 15 (Y15) by Wee1 kinase in the presence of DNA damage.
Thomas Caspari, Victoria Hilditch
doaj   +1 more source

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Nature Communications, 2021
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear.
Nikos E. Papaioannou, Natallia Salei, Stephan Rambichler, Kaushikk Ravi, Jelena Popovic, Vanessa Küntzel, Christian H. K. Lehmann, Remi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, Denise Messerer, Joana Carrelha, Caspar Ohnmacht, Dirk Haller, Ralf Stumm, Tobias Straub, Sten Eirik W. Jacobsen, Christian Schulz, David R. Withers, Gunnar Schotta, Diana Dudziak, Barbara U. Schraml   +22 more
doaj   +1 more source