Results 11 to 20 of about 29,264 (228)
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. [PDF]
Proceedings of the National Academy of Sciences, 1990 The human anti-oncoprotein p53 is shown to be a substrate of cdc2. The primary site of phosphorylation is serine-315. Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes. The phosphorylation of p53 is cell cycle-dependent. The abundance of p53 also oscillates during the cell cycle.
J R, Bischoff +4 more
openaire +4 more sources
Thr-161 Phosphorylation of Monomeric Cdc2 [PDF]
Journal of Biological Chemistry, 2002 Fully grown Xenopus oocyte is arrested at prophase I of meiosis. Re-entry into meiosis depends on the activation of MPF (M-phase promoting factor or cyclin B·Cdc2 complex), triggered by progesterone. The prophase-arrested oocyte contains a store of Cdc2.
de Smedt, Veronique +6 more
openaire +4 more sources
In VivoRegulation of Cyclin A/Cdc2 and Cyclin B/Cdc2 through Meiotic and Early Cleavage Cycles in Starfish [PDF]
Developmental Biology, 1998 In starfish, fertilization occurs naturally at late meiosis I. In the absence of fertilization, however, oocytes complete meiosis I and II, resulting in mature eggs arrested at the pronucleus stage, which are still fertilizable. In this study, we isolated cDNAs of starfish cyclin A and Cdc2, and monitored extensively the cell cycle dynamics of cyclin A
Okano-Uchida, Takayuki +5 more
openaire +3 more sources
A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2. [PDF]
Journal of Biological Chemistry, 1992 The Eg1 gene in Xenopus laevis is related in sequence to the cdc2+ gene. We show here that the Eg1 gene product (cdk2) possesses histone H1 protein kinase activity and binds to PSTAIR antibodies as well as to Sepharose beads linked to the 13-kDa product of the suc 1 gene (p13suc1).
Gabrielli, Brian G. +4 more
openaire +5 more sources
cdc2 phosphorylation is required for its interaction with cyclin. [PDF]
The EMBO Journal, 1991 Activation of the cdc2 protein kinase at different stages of the cell cycle is regulated by post-translational modifications and interactions with cyclins. We show that in vitro translated human cdc2 binds very poorly to A and B cyclins, unless it has been preincubated with a Xenopus egg extract. This results in the phosphorylation of cdc2 which allows
Ducommun, B +5 more
openaire +5 more sources
, 2021 Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and of ...
B Clark (11242545) +11 more
core +6 more sources
Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts. [PDF]
, 1995 Activation of p34cdc2 kinase is essential for entry into mitosis while subsequent deactivation and cyclin degradation are associated with exit. In Xenopus embryos, both of these phases are regulated by post-translational modifications and occur ...
Whitaker, Michael J. +2 more
core +4 more sources
Allergology International, 2021 Background: Follicular helper T (Tfh) cells represent a unique subset of helper CD4+ T cells in lymphoid follicles. Recently, Tfh cells were shown to play an important role in asthma through B cell differentiation.
Shogo Sakurai +12 more
doaj +1 more source
Biology Open, 2020 Checkpoint activation and gene expression modulation represent key determinants of cellular survival in adverse conditions. The former is regulated by cyclin-dependent kinases (CDKs) while the latter can be controlled by mitogen-activated protein kinases
Agamani Ghosal +2 more
doaj +1 more source
Frontiers in Immunology, 2022 Conventional dendritic cells (cDC) are a group of antigen-presenting cells specialized in priming T cell responses. In mice, splenic cDC are divided into conventional type 1 DC (cDC1) and conventional type 2 (cDC2).
Fernando Bandeira Sulczewski +7 more
doaj +1 more source