Results 11 to 20 of about 29,622 (230)

Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo [PDF]

BMC Cancer, 2008
Background Gliomas are the most common and aggressive primary brain tumors for which unfortunately no effective treatment modalities exist despite advances in molecular biology as the knowledge base to unravel the extremely complex molecular mechanisms ...
Wang Ai-Dong, Zhai De-Zhong, Dong Jun, Huang Qiang, Chen Hua, Lan Qing   +5 more
doaj   +6 more sources

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. [PDF]

Proceedings of the National Academy of Sciences, 1990
The human anti-oncoprotein p53 is shown to be a substrate of cdc2. The primary site of phosphorylation is serine-315. Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes. The phosphorylation of p53 is cell cycle-dependent. The abundance of p53 also oscillates during the cell cycle.
J R, Bischoff, P N, Friedman, D R, Marshak, C, Prives, D, Beach   +4 more
openaire   +4 more sources

Thr-161 Phosphorylation of Monomeric Cdc2 [PDF]

Journal of Biological Chemistry, 2002
Fully grown Xenopus oocyte is arrested at prophase I of meiosis. Re-entry into meiosis depends on the activation of MPF (M-phase promoting factor or cyclin B·Cdc2 complex), triggered by progesterone. The prophase-arrested oocyte contains a store of Cdc2.
de Smedt, Veronique, Poulhe, Robert, Cayla, Xavier, Dessauge, Frederic, Karaiskou, Anthi, Jessus, Catherine, Ozon, René   +6 more
openaire   +4 more sources

Raptor is phosphorylated by cdc2 during mitosis. [PDF]

PLoS ONE, 2010
The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division.
Dana M Gwinn, John M Asara, Reuben J Shaw   +2 more
doaj   +6 more sources

ets-2 Regulates cdc2 Kinase Activity in Mammalian Cells: Coordinated Expression of cdc2 and Cyclin A

Experimental Cell Research, 1995
ets-2 is a member of a family of transcription factors implicated in the regulation of gene expression during cell proliferation, cell differentiation, and development. We report that the ets-2 protein transactivates the promoter of the cdc2 gene which encodes a 34-kDa serine-threonine kinase required for mitotic initiation in mammalian cells ...
Wen SC, Ku DH, De Luca A, Claudio PP, Giordano A, CALABRETTA, Bruno   +5 more
openaire   +6 more sources

A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2. [PDF]

Journal of Biological Chemistry, 1992
The Eg1 gene in Xenopus laevis is related in sequence to the cdc2+ gene. We show here that the Eg1 gene product (cdk2) possesses histone H1 protein kinase activity and binds to PSTAIR antibodies as well as to Sepharose beads linked to the 13-kDa product of the suc 1 gene (p13suc1).
Gabrielli, Brian G., Roy, Linda M., Gautier, Jean, Philippe, Michel, Maller, James L.   +4 more
openaire   +5 more sources

Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts. [PDF]

, 1995
Activation of p34cdc2 kinase is essential for entry into mitosis while subsequent deactivation and cyclin degradation are associated with exit. In Xenopus embryos, both of these phases are regulated by post-translational modifications and occur ...
Whitaker, Michael J., Lindsay, Howard D., Ford, Christopher C.   +2 more
core   +4 more sources

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

Frontiers in Immunology, 2020
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals.
Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Xuezhi Dai, Xuezhi Dai, Diana Dudziak, David J. Rawlings, David J. Rawlings, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Pierre Guermonprez, Andrew P. Cope   +16 more
doaj   +1 more source

Saponin-based adjuvants enhance antigen cross-presentation in human CD11c+ CD1c+ CD5− CD163+ conventional type 2 dendritic cells

Journal for ImmunoTherapy of Cancer, 2023
Background Adjuvants are key for effective vaccination against cancer and chronic infectious diseases. Saponin-based adjuvants (SBAs) are unique among adjuvants in their ability to induce robust cell-mediated immune responses in addition to antibody ...
Harry Dolstra, Gosse J Adema, Nataschja I Ho, Lisa G M Huis in 't Veld, Jesper van Eck van der Sluijs, Branco M H Heuts, Maaike W G Looman, Esther D Kers-Rebel, Koen van den Dries, Joost H A Martens, Willemijn Hobo   +10 more
doaj   +1 more source

Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease [PDF]

, 2005
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD.
Prince, J. A., Blennow, Kaj,, Zetterberg, H, Hampel, Harald, Zetterberg, H., Buerger, Katharina, Zetterberg, Henrik,, Wahlund, LO, Buerger, K., Hampel, H, Blennow, K, Wahlund, Lars-Olof, Minthon, L, Blennow, K., Hampel, H., Prince, Jonathan A., Minthon, L., Buerger, K, Johansson, A., Minthon, Lennart, Johansson, Annica,, Prince, JA, Minthon, Lennart,, Johansson, A, Lund University.   +24 more
core   +1 more source