Results 41 to 50 of about 121,661 (250)

Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo

Antibodies, 2022
Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical tools ...
Jessica Bourque, Daniel Hawiger
doaj   +1 more source

Conventional Dendritic Cells Impair Recovery after Myocardial Infarction [PDF]

The Journal of Immunology, 2018
Abstract Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to pathogenesis of specific cardiac mononuclear phagocyte lineages, in particular ...
Jun Seong Lee, Se-Jin Jeong, Sinai Kim, Lorraine Chalifour, Tae Jin Yun, Mohammad Alam Miah, Bin Li, Abdelilah Majdoubi, Antoine Sabourin, Tibor Keler, Jean V Guimond, Elie Haddad, Eui-Young Choi, Slava Epelman, Jae-Hoon Choi, Jacques Thibodeau, Goo Taeg Oh, Cheolho Cheong   +17 more
openaire   +3 more sources

First Genomic Analysis of Dendritic Cells from Lung and Draining Lymph Nodes in Murine Asthma

International Journal of Genomics, 2015
Asthma is the consequence of allergic inflammation in the lung compartments and lung-draining lymph nodes. Dendritic cells initiate and promote T cell response and drive it to immunity or allergy.
Thomas Tschernig, Christina Hartwig, Andreas Jeron, Quoc Thai Dinh, Marcus Gereke, Dunja Bruder   +5 more
doaj   +1 more source

Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination

Cell Reports, 2020
Summary: Plasmacytoid dendritic cells (pDCs) and type 2 conventional dendritic cells (cDC2s) are currently under evaluation for use in cancer vaccines. Although both DC subsets can activate adaptive and innate lymphocytes, their capacity to recruit such ...
Jasper J.P. van Beek, Georgina Flórez-Grau, Mark A.J. Gorris, Till S.M. Mathan, Gerty Schreibelt, Kalijn F. Bol, Johannes Textor, I. Jolanda M. de Vries   +7 more
doaj   +1 more source

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells [PDF]

The Journal of Experimental Medicine, 2006
The mononuclear phagocyte (MP) system is a body-wide macrophage (MΦ) and dendritic cell (DC) network, which contributes to tissue homeostasis, inflammation, and immune defense. The in vivo origins of MPs remain poorly understood. Here, we use an adoptive precursor cell transfer strategy into MP-depleted mice to establish the in vivo differentiation ...
Varol, Chen, Landsman, Limor, Fogg, Darin K., Greenshtein, Liat, Gildor, Boaz, Margalit, Raanan, Kalchenko, Vyacheslav, Geissmann, Frederic, Jung, Steffen   +8 more
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Fungal immunization potentiates CD4+ T cell-independent cDC2 responses for cross-presentation

Frontiers in Immunology
The incidence rates of fungal infections are increasing, especially in immunocompromised individuals without an FDA-approved vaccine. Accumulating evidence suggests that T cells are instrumental in providing fungal immunity.
Nitish A. Kulkarni, Som G. Nanjappa, Som G. Nanjappa   +2 more
doaj   +1 more source

Interaction of Type 1 Porcine Reproductive and Respiratory Syndrome Virus With In Vitro Derived Conventional Dendritic Cells

Frontiers in Immunology, 2021
The present study delineates the interaction of a typical PRRSV1.1 isolate 3267 (moderate virulence) with in vitro derived pig conventional dendritic cells, cDC1, cDC2, and a CD14+ population (designated as CD14+ DCs).
Yanli Li, Enric Mateu, Enric Mateu
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Role of Tolerogenic Dendritic Cell Therapy in Autoimmune Diseases

مجله دانشکده پزشکی اصفهان, 2018
Dendritic cells (DCs) are special antigen-presenting cells that are important for activation of immune response and tolerance. Dendritic cells have been divided in two subtypes of conventional and plasmacytoid dendritic cells.
Maryam Shahidi, Seyed Mahmoud Hashemi, Davar Amani, Kaveh Baghaei   +3 more
doaj   +1 more source