Results 41 to 50 of about 6,856,628 (321)

The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

Journal for ImmunoTherapy of Cancer, 2019
Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a ...
Kalijn F. Bol, Gerty Schreibelt, Katrin Rabold, Stefanie K. Wculek, Julia Katharina Schwarze, Andrzej Dzionek, Alvaro Teijeira, Lana E. Kandalaft, Pedro Romero, George Coukos, Bart Neyns, David Sancho, Ignacio Melero, I. Jolanda M. de Vries   +13 more
doaj   +1 more source

Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]

PLoS ONE, 2013
Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda, Zhifei Shao, Ken D Yamaguchi, Takehiro Takagi, Corina N D'Alessandro-Gabazza, Osamu Taguchi, Hugh Salamon, Lawrence L K Leung, Esteban C Gabazza, John Morser   +9 more
doaj   +1 more source

Dendritic cells in experimental renal inflammation - Part I [PDF]

, 2011
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses.
Elfriede Noessner, Noessner, Elfriede, Segerer, S., Noessner, E, Stephan Segerer, Nößner, E., Peter J. Nelson, Lindenmeyer, Maja, Segerer, Stephan, Lindenmeyer, M., Lindenmeyer, M, Nelson, P.J., Maja Lindenmeyer, Nelson, Peter J., Segerer, S, Nelson, P J   +15 more
core   +1 more source

Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells

Frontiers in Immunology, 2019
Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. The effects of DCs on adaptive immune responses depend partly on functional specialization of distinct DC subsets, and partly on the activation state of DCs, which is ...
Claudia Carenza, Claudia Carenza, Francesca Calcaterra, Francesca Calcaterra, Ferdinando Oriolo, Ferdinando Oriolo, Clara Di Vito, Marta Ubezio, Matteo Giovanni Della Porta, Matteo Giovanni Della Porta, Domenico Mavilio, Domenico Mavilio, Silvia Della Bella, Silvia Della Bella   +13 more
doaj   +1 more source

GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2

Frontiers in Immunology, 2023
Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy.
Seyed Mohammad Lellahi, Seyed Mohammad Lellahi, Waqas Azeem, Waqas Azeem, Waqas Azeem, Yaping Hua, Yaping Hua, Benjamin Gabriel, Benjamin Gabriel, Kristin Paulsen Rye, Håkon Reikvam, Håkon Reikvam, Karl-Henning Kalland, Karl-Henning Kalland, Karl-Henning Kalland   +14 more
doaj   +1 more source

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

Journal for ImmunoTherapy of Cancer, 2021
Background Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer.
F. J. Cueto, C. del Fresno, Paola Brandi, A. Combes, Elena Hernández-García, A. R. Sanchez-Paulete, M. Enamorado, C. Bromley, M. Gómez, Ruth Conde-Garrosa, S. Mañes, S. Zelenay, I. Melero, S. Iborra, M. Krummel, D. Sancho   +15 more
semanticscholar   +1 more source

Dendritic cells in human renal inflammation - Part II [PDF]

, 2011
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. Here, we review the available information on their role in human renal inflammation.
Elfriede Noessner, Noessner, Elfriede, Segerer, S., Noessner, E, Stephan Segerer, Nößner, E., Peter J. Nelson, Lindenmeyer, Maja, Segerer, Stephan, Lindenmeyer, M., Lindenmeyer, M, Nelson, P.J., Maja Lindenmeyer, Nelson, Peter J., Segerer, S, Nelson, P J   +15 more
core   +1 more source

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

iScience, 2021
Summary Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated ...
S. Lukowski, Inga Rødahl, Samuel L. Kelly, Mei-Hua Yu, James Gotley, Chen-Hao Zhou, S. Millard, Stacey B. Andersen, Angelika N. Christ, G. Belz, I. Frazer, J. Chandra   +11 more
semanticscholar   +1 more source

Dendritic cells during Epstein Barr virus infection

Frontiers in Microbiology, 2014
Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This -herpesvirus infects primarily human B and epithelial cells, but has been reported to be sensed ...
Christian eMunz
doaj   +1 more source

Type 1 conventional dendritic cells and interferons are required for spontaneous CD4+ and CD8+ T‐cell protective responses to breast cancer

Clinical & Translational Immunology, 2021
To better understand how immune responses may be harnessed against breast cancer, we investigated which immune cell types and signalling pathways are required for spontaneous control of a mouse model of mammary adenocarcinoma.
Raphaël Mattiuz, Carine Brousse, M. Ambrosini, Jean-Charles Cancel, G. Bessou, J. Mussard, Amélien Sanlaville, C. Caux, N. Bendriss-Vermare, J. Valladeau-Guilemond, M. Dalod, K. Crozat   +11 more
semanticscholar   +1 more source