Results 21 to 30 of about 121,661 (250)

Cutting Edge: B220+CCR9− Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells [PDF]

The Journal of Immunology, 2009
Abstract Mouse lymphoid organs contain two major subsets of dendritic cells (DC) that differ in their phenotype and functions: conventional DC (cDC) and plasmacytoid DC (pDC). Recently, it has been proposed that differential expression of CCR9 could distinguish functionally distinct pDC subsets.
Elodie, Segura, June, Wong, José A, Villadangos   +2 more
openaire   +2 more sources

Intratumoral Combinatorial Administration of CD1c (BDCA-1)⁺ Myeloid Dendritic Cells Plus Ipilimumab and Avelumab in Combination with Intravenous Low-Dose Nivolumab in Patients with Advanced Solid Tumors: A Phase IB Clinical Trial

Vaccines, 2020
Intratumoral (IT) myeloid dendritic cells (myDCs) play a pivotal role in re-licensing antitumor cytotoxic T lymphocytes. IT injection of the IgG1 monoclonal antibodies ipilimumab and avelumab may induce antibody-dependent cellular cytotoxicity, thereby ...
Julia Katharina Schwarze, Gil Awada, Louise Cras, Jens Tijtgat, Ramses Forsyth, Inès Dufait, Sandra Tuyaerts, Ivan Van Riet, Bart Neyns   +8 more
doaj   +1 more source

Recruitment and Differentiation of Conventional Dendritic Cell Precursors in Tumors [PDF]

The Journal of Immunology, 2009
Abstract The origin of dendritic cells (DCs) in tumors remains obscure. Recent studies indicate that conventional DCs (cDCs) in lymphoid tissues arise from a distinct population of committed cDC precursors (pre-cDCs) that originate in bone marrow and migrate via blood.
Jun, Diao, Jun, Zhao, Erin, Winter, Mark S, Cattral   +3 more
openaire   +2 more sources

Usp18 Promotes Conventional CD11b+ Dendritic Cell Development [PDF]

The Journal of Immunology, 2012
Abstract Dendritic cells (DCs) represent the key cells linking innate and adaptive immune responses. It is critical to understand the molecular factors regulating DC differentiation. Usp18 is an IFN-inducible member of the ubiquitin-specific protease family, which deconjugates ubiquitin-like modifier ISG15 from target proteins and ...
Xiu-Li, Cong, Miao-Chia, Lo, Brian A, Reuter, Ming, Yan, Jun-Bao, Fan, Dong-Er, Zhang   +5 more
openaire   +2 more sources

The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

Journal for ImmunoTherapy of Cancer, 2019
Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a ...
Kalijn F. Bol, Gerty Schreibelt, Katrin Rabold, Stefanie K. Wculek, Julia Katharina Schwarze, Andrzej Dzionek, Alvaro Teijeira, Lana E. Kandalaft, Pedro Romero, George Coukos, Bart Neyns, David Sancho, Ignacio Melero, I. Jolanda M. de Vries   +13 more
doaj   +1 more source

Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells

Frontiers in Immunology, 2019
Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. The effects of DCs on adaptive immune responses depend partly on functional specialization of distinct DC subsets, and partly on the activation state of DCs, which is ...
Claudia Carenza, Claudia Carenza, Francesca Calcaterra, Francesca Calcaterra, Ferdinando Oriolo, Ferdinando Oriolo, Clara Di Vito, Marta Ubezio, Matteo Giovanni Della Porta, Matteo Giovanni Della Porta, Domenico Mavilio, Domenico Mavilio, Silvia Della Bella, Silvia Della Bella   +13 more
doaj   +1 more source

GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2

Frontiers in Immunology, 2023
Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy.
Seyed Mohammad Lellahi, Seyed Mohammad Lellahi, Waqas Azeem, Waqas Azeem, Waqas Azeem, Yaping Hua, Yaping Hua, Benjamin Gabriel, Benjamin Gabriel, Kristin Paulsen Rye, Håkon Reikvam, Håkon Reikvam, Karl-Henning Kalland, Karl-Henning Kalland, Karl-Henning Kalland   +14 more
doaj   +1 more source

Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]

PLoS ONE, 2013
Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda, Zhifei Shao, Ken D Yamaguchi, Takehiro Takagi, Corina N D'Alessandro-Gabazza, Osamu Taguchi, Hugh Salamon, Lawrence L K Leung, Esteban C Gabazza, John Morser   +9 more
doaj   +1 more source

Dendritic cells during Epstein Barr virus infection

Frontiers in Microbiology, 2014
Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This -herpesvirus infects primarily human B and epithelial cells, but has been reported to be sensed ...
Christian eMunz
doaj   +1 more source

In Vivo Induction of Immune Responses to Pathogens by Conventional Dendritic Cells [PDF]

Immunity, 2008
Specific defense mechanisms against pathogens are fulfilled by different subsets of nonmucosal conventional dendritic cells (DCs), including migratory Langerhans cells (LCs), dermal DCs, and resident CD8(+) and CD8(-) DCs found in lymphoid organs. Dermal DCs capture antigens in the skin and migrate to lymph nodes, where they can transfer the antigens ...
López-Bravo, María, Ardavín, Carlos
openaire   +3 more sources