Results 21 to 30 of about 6,856,628 (321)

Type 1 conventional dendritic cells regulate innate immunity during fungal pneumonia [PDF]

mBio
Aspergillus fumigatus is a ubiquitous mold that is the primary etiological agent of invasive pulmonary aspergillosis (IPA), a severe lung infection in immunocompromised patients with extreme mortality.
Pari M. Dhruva, Thomas E. Draper, Camille A. Chiller, MaryJane Jones, Chad Steele   +4 more
doaj   +2 more sources

mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells [PDF]

Frontiers in Immunology, 2019
In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved.
Alicia R. Watson, Alicia R. Watson, Helong Dai, Helong Dai, Yawen Zheng, Yawen Zheng, Ryosuke Nakano, Anastasios D. Giannou, Ashley V. Menk, Donna B. Stolz, Greg M. Delgoffe, Greg M. Delgoffe, Angus W. Thomson, Angus W. Thomson   +13 more
doaj   +3 more sources

Conventional Dendritic Cells Impair Recovery after Myocardial Infarction [PDF]

The Journal of Immunology, 2018
Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to ...
Jun Seong Lee, Se-Jin Jeong, Sinai Kim, L. Chalifour, T. Yun, M. Miah, Bin Li, A. Majdoubi, Antoine Sabourin, T. Keler, Jean Guimond, E. Haddad, E. Choi, S. Epelman, Jae-Hoon Choi, J. Thibodeau, G. Oh, C. Cheong   +17 more
semanticscholar   +4 more sources

STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation [PDF]

iScience, 2020
Summary: Signaling through stimulator of interferon genes (STING) leads to the production of type I interferons (IFN-Is) and inflammatory cytokines. A gain-of-function mutation in STING was identified in an autoinflammatory disease (STING-associated ...
Arthid Thim-uam, Thaneas Prabakaran, Mookmanee Tansakul, Jiradej Makjaroen, Piriya Wongkongkathep, Naphat Chantaravisoot, Thammakorn Saethang, Asada Leelahavanichkul, Thitima Benjachat, Søren Paludan, Trairak Pisitkun, Prapaporn Pisitkun   +11 more
doaj   +6 more sources

Sequential activation of conventional and plasmacytoid dendritic cells in autoimmune pancreatitis and systemic lupus erythematosus: similarities and dissimilarities

Frontiers in Immunology
Type 1 autoimmune pancreatitis (AIP) and systemic lupus erythematosus (SLE) are caused by type I IFNs secreted by plasmacytoid dendritic cells (pDCs).
Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Warren Strober, Masatoshi Kudo   +5 more
doaj   +3 more sources

Dendritic cell regulation of immunity to Leishmania donovani [PDF]

, 2010
Dendritic cells lie at the interface of innate and adaptive immunity, critically contributing to the generation of an antigen-specific immune response.
Owens, Benjamin M.J.
core   +6 more sources

Regulation of the Migration of Distinct Dendritic Cell Subsets

Frontiers in Cell and Developmental Biology, 2021
Dendritic cells (DCs), a class of antigen-presenting cells, are widely present in tissues and apparatuses of the body, and their ability to migrate is key for the initiation of immune activation and tolerogenic immune responses.
Meng Feng, Shuping Zhou, Yong Yu, Qinghong Su, Xiaofan Li, Wei Lin   +5 more
doaj   +1 more source

OVA-PEG-R848 nanocapsules stimulate neonatal conventional and plasmacytoid dendritic cells

Frontiers in Pediatrics, 2022
Childhood mortality represents a major issue with 5. 3 million worldwide deaths of children under 5 years of age in 2019. Approximately half of those deaths can be attributed to easily preventable, infectious diseases.
Sebastian Wirsching, Marina Machtakova, Frauke Borgans, Frauke Borgans, Leah Pretsch, Michael Fichter, Michael Fichter, Michael Fichter, Maximiliano L. Cacicedo, Héloïse Thérien-Aubin, Héloïse Thérien-Aubin, Katharina Landfester, Stephan Gehring   +12 more
doaj   +1 more source

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches.

Immunity, 2022
Reinvigoration of exhausted CD8+ T (Tex) cells by checkpoint immunotherapy depends on the activation of precursors of exhausted T (Tpex) cells, but the local anatomical context of their maintenance, differentiation, and interplay with other cells is not ...
Sabrina Dähling, A. Mansilla, Konrad Knöpper, Anika Grafen, Daniel T. Utzschneider, Milas Ugur, Paul G. Whitney, A. Bachem, P. Arampatzi, F. Imdahl, T. Kaisho, D. Zehn, Frederick Klauschen, N. Garbi, A. Kallies, A. Saliba, G. Gasteiger, S. Bedoui, W. Kastenmüller   +18 more
semanticscholar   +1 more source

Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

Immunity, 2021
SUMMARY Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor immunity. To delineate the DC states associated with productive anti-tumor T cell immunity, we compared spontaneously regressing and progressing ...
Ellen Duong, Tim B. Fessenden, E. Lutz, T. Dinter, Leon Yim, S. Blatt, A. Bhutkar, K. Wittrup, S. Spranger   +8 more
semanticscholar   +1 more source