Results 21 to 30 of about 6,907,839 (294)

Cutting Edge: B220+CCR9− Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells [PDF]

The Journal of Immunology, 2009
Abstract Mouse lymphoid organs contain two major subsets of dendritic cells (DC) that differ in their phenotype and functions: conventional DC (cDC) and plasmacytoid DC (pDC). Recently, it has been proposed that differential expression of CCR9 could distinguish functionally distinct pDC subsets.
Elodie, Segura, June, Wong, José A, Villadangos   +2 more
openaire   +2 more sources

Recruitment and Differentiation of Conventional Dendritic Cell Precursors in Tumors [PDF]

The Journal of Immunology, 2009
Abstract The origin of dendritic cells (DCs) in tumors remains obscure. Recent studies indicate that conventional DCs (cDCs) in lymphoid tissues arise from a distinct population of committed cDC precursors (pre-cDCs) that originate in bone marrow and migrate via blood.
Jun, Diao, Jun, Zhao, Erin, Winter, Mark S, Cattral   +3 more
openaire   +2 more sources

Usp18 Promotes Conventional CD11b+ Dendritic Cell Development [PDF]

The Journal of Immunology, 2012
Abstract Dendritic cells (DCs) represent the key cells linking innate and adaptive immune responses. It is critical to understand the molecular factors regulating DC differentiation. Usp18 is an IFN-inducible member of the ubiquitin-specific protease family, which deconjugates ubiquitin-like modifier ISG15 from target proteins and ...
Xiu-Li, Cong, Miao-Chia, Lo, Brian A, Reuter, Ming, Yan, Jun-Bao, Fan, Dong-Er, Zhang   +5 more
openaire   +2 more sources

The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

Journal for ImmunoTherapy of Cancer, 2019
Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a ...
Kalijn F. Bol, Gerty Schreibelt, Katrin Rabold, Stefanie K. Wculek, Julia Katharina Schwarze, Andrzej Dzionek, Alvaro Teijeira, Lana E. Kandalaft, Pedro Romero, George Coukos, Bart Neyns, David Sancho, Ignacio Melero, I. Jolanda M. de Vries   +13 more
doaj   +1 more source

Dendritic cells in experimental renal inflammation - Part I [PDF]

, 2011
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses.
Elfriede Noessner, Noessner, Elfriede, Segerer, S., Noessner, E, Stephan Segerer, Nößner, E., Peter J. Nelson, Lindenmeyer, Maja, Segerer, Stephan, Lindenmeyer, M., Lindenmeyer, M, Nelson, P.J., Maja Lindenmeyer, Nelson, Peter J., Segerer, S, Nelson, P J, Nelson PJ, Lindenmeyer M, Noessner E, Segerer S   +19 more
core   +1 more source

Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells

Frontiers in Immunology, 2019
Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. The effects of DCs on adaptive immune responses depend partly on functional specialization of distinct DC subsets, and partly on the activation state of DCs, which is ...
Claudia Carenza, Claudia Carenza, Francesca Calcaterra, Francesca Calcaterra, Ferdinando Oriolo, Ferdinando Oriolo, Clara Di Vito, Marta Ubezio, Matteo Giovanni Della Porta, Matteo Giovanni Della Porta, Domenico Mavilio, Domenico Mavilio, Silvia Della Bella, Silvia Della Bella   +13 more
doaj   +1 more source

Dendritic cells in human renal inflammation - Part II [PDF]

, 2011
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. Here, we review the available information on their role in human renal inflammation.
Elfriede Noessner, Noessner, Elfriede, Segerer, S., Noessner, E, Stephan Segerer, Nößner, E., Peter J. Nelson, Lindenmeyer, Maja, Segerer, Stephan, Lindenmeyer, M., Lindenmeyer, M, Nelson, P.J., Maja Lindenmeyer, Nelson, Peter J., Segerer, S, Nelson, P J   +15 more
core   +1 more source

Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]

PLoS ONE, 2013
Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda, Zhifei Shao, Ken D Yamaguchi, Takehiro Takagi, Corina N D'Alessandro-Gabazza, Osamu Taguchi, Hugh Salamon, Lawrence L K Leung, Esteban C Gabazza, John Morser   +9 more
doaj   +1 more source

CD14 Expressing Precursors Give Rise to Highly Functional Conventional Dendritic Cells for Use as Dendritic Cell Vaccine [PDF]

Cancers, 2021
Induction of long-lasting immunity by dendritic cells (DCs) makes them attractive candidates for anti-tumor vaccination. Although DC vaccinations are generally considered safe, clinical responses remain inconsistent in clinical trials. This initiated studies to identify subsets of DCs with superior capabilities to induce effective and memory anti-tumor
Maud Plantinga, Denise A. M. H. van den Beemt, Ester Dünnebach, Stefan Nierkens   +3 more
openaire   +3 more sources

Subsets of migrating intestinal dendritic cells [PDF]

, 2010
Dendritic cells (DCs) in the intestine are heterogeneous. Phenotypically different populations of conventional DCs have been identified in the intestinal lamina propria, Peyer's patches, and in the draining mesenteric lymph nodes, to which these DCs ...
Yrlid, Ulf, Cerovic, Vuk, MacPherson, Gordon, Milling, Simon, Yrlid, Ulf,   +4 more
core   +1 more source