Results 31 to 40 of about 6,856,628 (321)

Role of conventional dendritic cells in schistosomiasis-induced pulmonary hypertension. [PDF]

Clin Sci (Lond)
Background: Schistosomiasis is a major cause of pulmonary hypertension (PH) worldwide, and CD4 T cells are critical in disease pathogenesis. The role of dendritic cells (DCs) in Schistosoma-induced PH (SchPH) is unknown. There are two types of conventional DCs, cDC1 and cDC2, that prototypically activate CD8 and CD4 T cells, respectively.
Mickael C, Kumar R, Fonseca Balladares DC, Nolan K, Lee MH, Kassa B, Menezes TCF, Lau-Xiao A, Sahota A, Sanders L, Tuscan K, Gandjeva A, Cautivo KM, Molofsky A, Graham BB.   +14 more
europepmc   +3 more sources

Human Dendritic Cell Subset Isolation by Magnetic Bead Sorting: A Protocol to Efficiently Obtain Pure Populations

Bio-Protocol, 2023
Dendritic cells have been investigated for cell-based immunotherapy for various applications. The low abundance of dendritic cells in blood hampers their clinical application, resulting in the use of monocyte-derived dendritic cells as an alternative ...
Georgina Flórez-Grau, Jorge Cuenca Escalona, Helena Lacasta-Mambo, Daphne Roelofs, Johanna Bödder, Ruben Beuk, Gerty Schreibelt, I Jolanda de Vries   +7 more
doaj   +1 more source

Hypoxia‐driven immunosuppression by Treg and type‐2 conventional dendritic cells in HCC

Hepatology, 2022
Hypoxia is one of the central players in shaping the immune context of the tumor microenvironment (TME). However, the complex interplay between immune cell infiltrates within the hypoxic TME of HCC remains to be elucidated.
Sheena Suthen, C. Lim, P. Nguyen, C. Dutertre, H. Lai, M. Wasser, C. Chua, T. Lim, W. Leow, T. Loh, W. Wan, Y. Pang, G. Soon, P. Cheow, J. Kam, S. Iyer, A. Kow, W. Tam, T. Shuen, H. Toh, Y. Dan, G. Bonney, C. Chan, A. Chung, B. Goh, Weiwei Zhai, F. Ginhoux, P. Chow, S. Albani, Valerie Chew   +29 more
semanticscholar   +1 more source

Cutting Edge: B220+CCR9− Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells [PDF]

The Journal of Immunology, 2009
Abstract Mouse lymphoid organs contain two major subsets of dendritic cells (DC) that differ in their phenotype and functions: conventional DC (cDC) and plasmacytoid DC (pDC). Recently, it has been proposed that differential expression of CCR9 could distinguish functionally distinct pDC subsets.
Elodie, Segura, June, Wong, José A, Villadangos   +2 more
openaire   +2 more sources

Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage

Nature Communications, 2022
Plasmacytoid and conventional dendritic cells (pDC and cDC) are generated from progenitor cells in the bone marrow and commitment to pDCs or cDC subtypes may occur in earlier and later progenitor stages. Cells within the CD11c+MHCII−/loSiglec-H+CCR9lo DC
Konstantin Lutz, Andrea Musumeci, Christopher Sie, Ezgi Dursun, Elena Winheim, J. Bagnoli, C. Ziegenhain, Lisa Rausch, Volker Bergen, Malte D. Luecken, R. Oostendorp, B. Schraml, Fabian J. Theis, W. Enard, T. Korn, A. Krug   +15 more
semanticscholar   +1 more source

Intratumoral Combinatorial Administration of CD1c (BDCA-1)⁺ Myeloid Dendritic Cells Plus Ipilimumab and Avelumab in Combination with Intravenous Low-Dose Nivolumab in Patients with Advanced Solid Tumors: A Phase IB Clinical Trial

Vaccines, 2020
Intratumoral (IT) myeloid dendritic cells (myDCs) play a pivotal role in re-licensing antitumor cytotoxic T lymphocytes. IT injection of the IgG1 monoclonal antibodies ipilimumab and avelumab may induce antibody-dependent cellular cytotoxicity, thereby ...
Julia Katharina Schwarze, Gil Awada, Louise Cras, Jens Tijtgat, Ramses Forsyth, Inès Dufait, Sandra Tuyaerts, Ivan Van Riet, Bart Neyns   +8 more
doaj   +1 more source

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Nature Communications, 2021
Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature.
Nikos E. Papaioannou, N. Salei, Stephan Rambichler, Kaushik Ravi, Jelena Popović, Vanessa Küntzel, Christian H. K. Lehmann, Rémi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, D. Messerer, J. Carrelha, C. Ohnmacht, D. Haller, R. Stumm, T. Straub, S. Jacobsen, C. Schulz, D. Withers, Gunnar Schotta, D. Dudziak, B. Schraml   +22 more
semanticscholar   +1 more source

Usp18 Promotes Conventional CD11b+ Dendritic Cell Development [PDF]

The Journal of Immunology, 2012
Abstract Dendritic cells (DCs) represent the key cells linking innate and adaptive immune responses. It is critical to understand the molecular factors regulating DC differentiation. Usp18 is an IFN-inducible member of the ubiquitin-specific protease family, which deconjugates ubiquitin-like modifier ISG15 from target proteins and ...
Xiu-Li, Cong, Miao-Chia, Lo, Brian A, Reuter, Ming, Yan, Jun-Bao, Fan, Dong-Er, Zhang   +5 more
openaire   +2 more sources

Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis.

Journal of Hepatology, 2022
BACKGROUND & AIMS Primary sclerosing cholangitis (PSC) is a progressive cholangiopathy with fibrotic stricturing and inflammation of bile ducts, which seems to be driven by a maladaptive immune response to bile duct injury.
Anna-Lena Müller, C. Casar, M. Preti, D. Krzikalla, C. Gottwick, P. Averhoff, P. Rosenstiel, M. Gelderblom, M. Altfeld, A. Lohse, S. Steinmann, M. Sebode, J. Krause, D. Schwinge, C. Schramm, A. Carambia, J. Herkel   +16 more
semanticscholar   +1 more source

Recruitment and Differentiation of Conventional Dendritic Cell Precursors in Tumors [PDF]

The Journal of Immunology, 2009
Abstract The origin of dendritic cells (DCs) in tumors remains obscure. Recent studies indicate that conventional DCs (cDCs) in lymphoid tissues arise from a distinct population of committed cDC precursors (pre-cDCs) that originate in bone marrow and migrate via blood.
Jun, Diao, Jun, Zhao, Erin, Winter, Mark S, Cattral   +3 more
openaire   +2 more sources