Results 31 to 40 of about 121,661 (250)

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells [PDF]

Journal of Experimental Medicine, 2010
Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid tissues, the transcription factors controlling their development and their relationship to other DC subsets remain unclear. Mice lacking the transcription factor Batf3 have a defect in the development of CD8α+ conventional DCs (cDCs) within lymphoid tissues.
Edelson, Brian T, KC, Wumesh, Juang, Richard, Kohyama, Masako, Benoit, Loralyn A, Klekotka, Paul A, Moon, Clara, Albring, Jörn C, Ise, Wataru, Michael, Drew G, Bhattacharya, Deepta, Stappenbeck, Thaddeus S, Holtzman, Michael J, Sung, Sun-Sang J, Murphy, Theresa L, Hildner, Kai, Murphy, Kenneth M   +16 more
openaire   +3 more sources

Bluetongue Virus Targets Conventional Dendritic Cells in Skin Lymph [PDF]

Journal of Virology, 2009
ABSTRACTBluetongue virus (BTV) is the etiological agent of bluetongue, a hemorrhagic disease of ruminants (particularly sheep), which causes important economic losses around the world. BTV is transmitted primarily via the bites of infected midges, which inject the virus into the ruminant's skin during blood feeding.
Hemati, Behzad, Contreras, Vanessa, Urien, Celine, Bonneau, Michel, Takamatsu, Haru-Hisa, Mertens, Peter P.C., Breard, Emmanuel, Sailleau, Corinne, Zientara, Stéphan, Schwartz-Cornil, Isabelle   +9 more
openaire   +4 more sources

Migratory conventional dendritic cells in the induction of peripheral T cell tolerance [PDF]

Journal of Leukocyte Biology, 2013
ABSTRACTConventional DCs are an extremely heterogeneous cell population that comprises several different subsets. A major distinction can be made between lymphoid-resident DCs that are present in the lymphoid tissues and the blood and migratory DCs that reside in the nonlymphoid tissues and migrate to the lymph nodes, both in homeostatic conditions and
Achille, Broggi, Ivan, Zanoni, Francesca, Granucci   +2 more
openaire   +2 more sources

Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells [PDF]

Blood, 2012
AbstractDendritic cell (DC) homeostasis in peripheral tissues reflect a balance between DC generation, migration, and death. The current model of DC ontogeny indicates that pre-cDCs are committed to become terminal conventional DCs (cDCs). Here, we report the unexpected finding that proliferating immunostimulatory CD11c+ MHC class II+ cDCs derived from
Jun, Diao, Anastassia, Mikhailova, Michael, Tang, Hongtao, Gu, Jun, Zhao, Mark S, Cattral   +5 more
openaire   +2 more sources

In Vitro and In Vivo Effects of Ketamine on Generation and Function of Dendritic Cells

Journal of Pharmacological Sciences, 2011
.: The question about how intravenous anesthetic reagents affect the development and function of dendritic cell subsets still has no comprehensive answers.
Jingxian Zeng, Shuxuan Xia, Wa Zhong, Jie Li, Liling Lin   +4 more
doaj   +1 more source

Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence.

PLoS ONE, 2021
Regulation of dendritic cell functions is a complex process in which several mediators play diverse roles as a network in a context-dependent manner. The precise mechanisms underlying dendritic cell functions have remained to be addressed.
Hesam Movassagh, Lianyu Shan, Latifa Koussih, Abdulaziz Alamri, Nazila Ariaee, Sam K P Kung, Abdelilah S Gounni   +6 more
doaj   +1 more source

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

Nature Communications, 2021
Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic ...
Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Erica E. Vine, Hafsa Rana, Heeva Baharlou, Peter Vegh, Thomas R. O’Neil, Anneliese S. Ashhurst, James Fletcher, Grant P. Parnell, J. Dinny Graham, Najla Nasr, Jake J. K. Lim, Laith Barnouti, Peter Haertsch, Martijn P. Gosselink, Angelina Di Re, Faizur Reza, Grahame Ctercteko, Gregory J. Jenkins, Andrew J. Brooks, Ellis Patrick, Scott N. Byrne, Eric Hunter, Muzlifah A. Haniffa, Anthony L. Cunningham, Andrew N. Harman   +27 more
doaj   +1 more source

CD14 Expressing Precursors Give Rise to Highly Functional Conventional Dendritic Cells for Use as Dendritic Cell Vaccine [PDF]

Cancers, 2021
Induction of long-lasting immunity by dendritic cells (DCs) makes them attractive candidates for anti-tumor vaccination. Although DC vaccinations are generally considered safe, clinical responses remain inconsistent in clinical trials. This initiated studies to identify subsets of DCs with superior capabilities to induce effective and memory anti-tumor
Maud Plantinga, Denise A. M. H. van den Beemt, Ester Dünnebach, Stefan Nierkens   +3 more
openaire   +2 more sources

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis

Frontiers in Immunology, 2018
ObjectiveDendritic cells (DCs) are key orchestrators of immune function. To date, rheumatoid arthritis (RA) researchers have predominantly focused on a potential pathogenic role for CD1c+ DCs.
Faye A. H. Cooles, Faye A. H. Cooles, Amy E. Anderson, Amy E. Anderson, Andrew Skelton, Andrew Skelton, Arthur G. Pratt, Arthur G. Pratt, Mariola S. Kurowska-Stolarska, Mariola S. Kurowska-Stolarska, Iain McInnes, Iain McInnes, Catharien M. U. Hilkens, Catharien M. U. Hilkens, John D. Isaacs, John D. Isaacs   +15 more
doaj   +1 more source

Dendritic Cell and Regulatory T Cell numbers in relation to Breast Cancer Progression and Metastasis [PDF]

International Journal of Medical Arts
Background: Breast cancer ranks as the second cause of cancer-related deaths in Egypt. Numerous immunomodulatory pathways underscore the immune system’s involvement in cancer prognosis.
Walaa Ashry, Amal Ayoub, Azza Ghanem, Amany Tawfeik, Effat Hassan   +4 more
doaj   +1 more source