Results 51 to 60 of about 6,907,839 (294)

Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination

Cell Reports, 2020
Summary: Plasmacytoid dendritic cells (pDCs) and type 2 conventional dendritic cells (cDC2s) are currently under evaluation for use in cancer vaccines. Although both DC subsets can activate adaptive and innate lymphocytes, their capacity to recruit such ...
Jasper J.P. van Beek, Georgina Flórez-Grau, Mark A.J. Gorris, Till S.M. Mathan, Gerty Schreibelt, Kalijn F. Bol, Johannes Textor, I. Jolanda M. de Vries   +7 more
doaj   +1 more source

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells [PDF]

The Journal of Experimental Medicine, 2006
The mononuclear phagocyte (MP) system is a body-wide macrophage (MΦ) and dendritic cell (DC) network, which contributes to tissue homeostasis, inflammation, and immune defense. The in vivo origins of MPs remain poorly understood. Here, we use an adoptive precursor cell transfer strategy into MP-depleted mice to establish the in vivo differentiation ...
Varol, Chen, Landsman, Limor, Fogg, Darin K., Greenshtein, Liat, Gildor, Boaz, Margalit, Raanan, Kalchenko, Vyacheslav, Geissmann, Frederic, Jung, Steffen   +8 more
openaire   +3 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Fungal immunization potentiates CD4+ T cell-independent cDC2 responses for cross-presentation

Frontiers in Immunology
The incidence rates of fungal infections are increasing, especially in immunocompromised individuals without an FDA-approved vaccine. Accumulating evidence suggests that T cells are instrumental in providing fungal immunity.
Nitish A. Kulkarni, Som G. Nanjappa, Som G. Nanjappa   +2 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages. [PDF]

, 2008
BACKGROUND: Transcriptional profiling using microarrays provides a unique opportunity to decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium ...
Waddell, Simon, Castagnoli, PR, Mattia Pelizzola (20247), Castagnoli, Paola Ricciardi, Pelizzola Mattia, Foti, M, Maria Foti, Butcher, Philip, Neyrolles, Olivier, Neyrolles, O, Antoine Tanne, Simon J Waddell, Olivier Neyrolles, Pelizzola, M, Tailleux, L, Simon J. Waddell, Antoine Tanne (272975), Philip D Butcher (16047203), Maria Foti (20249), Neil G. Stoker, Stoker Neil G., Waddell, SJ, Tailleux Ludovic, Tailleux, Ludovic, Gicquel, Brigitte, Simon Waddell (4462816), Castagnoli Paola Ricciardi, Brigitte Gicquel, Philip D Butcher, Tanne Antoine, Alessandra Mortellaro (272973), Mortellaro, A, Gicquel Brigitte, Stoker, Neil, Philip D. Butcher, Butcher, PD, Tanne, Antoine, Olivier Neyrolles (72204), Tanne, A, Mortellaro, Alessandra, Paola Ricciardi Castagnoli (16048310), Ludovic Tailleux, Michael Withers (272974), Neyrolles Olivier, Withers Michael, Foti, Maria, Waddell Simon J., Stoker, NG, Michael Withers, Pelizzola, Mattia, Mortellaro Alessandra, Brigitte Gicquel (31454), Ludovic Tailleux (72195), Neil G Stoker (16048313), Alessandra Mortellaro, Neil G Stoker, Foti Maria, Gicquel, B, Butcher Philip D., Withers, M, Mattia Pelizzola, Paola Ricciardi Castagnoli, Withers, Michael, Waddel S.J., Withers M., Neyrolles O., Tanne A., Tailleux L., Foti M., Stoker N.G., Butcher P.D., Pelizzola M., Mortellaro A., Gicquel B., Castagnoli P.R.   +74 more
core   +1 more source

Interaction of Type 1 Porcine Reproductive and Respiratory Syndrome Virus With In Vitro Derived Conventional Dendritic Cells

Frontiers in Immunology, 2021
The present study delineates the interaction of a typical PRRSV1.1 isolate 3267 (moderate virulence) with in vitro derived pig conventional dendritic cells, cDC1, cDC2, and a CD14+ population (designated as CD14+ DCs).
Yanli Li, Enric Mateu, Enric Mateu
doaj   +1 more source

Structural and functional convergence and divergence of myeloid dendritic cells and conventional dendritic cells

Sokoto Journal of Medical Laboratory Science
Dendritic cells (DCs) are essential regulators of immune responses, acting as a bridge between innate and adaptive immunity. They play a critical role in recognizing and responding to microbial threats and malignant transformations, ensuring appropriate immune activation.
Danjuma, Jonathan Joshua, Saidu, Hayatu
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infections [PDF]

, 2007
Mycobacterium tuberculosis (M. tuberculosis) is responsible for 2 million deaths annually. In recent years co-infection with HIV and drug-resistant strains has led to the increase in clinical cases of tuberculosis.
Krishnan, Nitya
core