Results 71 to 80 of about 6,856,628 (321)

Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function

Open Life Sciences, 2021
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a severe syndrome lacking efficient therapy and resulting in high morbidity and mortality.
Guo Bingnan, Peng Yigen, Gu Yuting, Zhong Yi, Su Chenglei, Liu Lin, Chai Dafei, Song Tengfei, Zhao Ningjun, Yan Xianliang, Xu Tie   +10 more
doaj   +1 more source

Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo [PDF]

, 2004
Strategies to enhance the immunogenicity of tumors are urgently needed. Although vaccination with irradiated dying lymphoma cells recruits a tumor-specific immune response, its efficiency as immunogen is poor.
Zimmermann, VS, Voll, Reinhard E., Turnay, Javier, Manfredi, Angelo A., Turnay, J, Dumitriu, IE, Voll, RE, Zimmermann, Valérie S, Angelo A. Manfredi, Bertling, Wolf, Rovere-Querini, P, Kalden, JR, Udo S. Gaipl, Herrmann, M, Attilio Bondanza, Gaipl, Udo S, Wolf Bertling, Bertling, W, Patrizia Rovere-Querini, Ingrid E. Dumitriu, Bondanza, Attilio, Stach, Christian M., Pöschl, E, Stach, Christian M, Gaipl, US, Javier Turnay, Herrmann, Martin, Martin Herrmann, Dumitriu, Ingrid E., Rovere-Querini, Patrizia, Christian M. Stach, Manfredi, Angelo A, Kalden, Joachim R, Valérie S. Zimmermann, Pöschl, Ernst, Stach, CM, Dumitriu, Ingrid E; id_orcid, Gaipl, Udo S., Joachim R. Kalden, Bondanza, A, Zimmermann, Valérie S., Voll, Reinhard E, Kalden, Joachim R., Reinhard E. Voll, Manfredi, AA, Ernst Pöschl, Dumitriu IE, ROVERE QUERINI , PATRIZIA, Kalden JR, Bertling W, Turnay J, BONDANZA , ATTILIO, Herrmann M., Poschl E, Zimmermann VS, Gaipl US, Stach CM, MANFREDI , ANGELO ANDREA M. A., Voll RE   +58 more
core   +1 more source

Critical roles of conventional dendritic cells in autoimmune hepatitis via autophagy regulation

Cell Death and Disease, 2020
Autoimmune hepatitis (AIH) is a necroinflammatory disease associated with interactive cell populations of the innate and adaptive immune systems. The contribution of conventional dendritic cells (cDCs) to AIH and the underlying mechanism remain poorly ...
Xiao-Li Fan, Ruo-ting Men, Chen-Na Huang, Mengyi Shen, Tingting Wang, Y. Ghnewa, Yun Ma, Tinghong Ye, Li Yang   +8 more
semanticscholar   +1 more source

Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure [PDF]

, 2005
The accumulation of the scrapie agent in lymphoid tissues following inoculation via the skin is critical for efficient neuroinvasion, but how the agent is initially transported from the skin to the draining lymph node is not known. Langerhans cells (LCs)
Hopkins, John, Mabbott, Neil; id_orcid, John Hopkins, Joanne Mohan, Mohan, Joanne, Neil A. Mabbott   +5 more
core   +1 more source

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis [PDF]

, 2013
Activation of dendritic cells by different pathogens induces the secretion of proinflammatory mediators resulting in local inflammation. Importantly, innate immunity must be properly controlled, as its continuous activation leads to the development of ...
Szász, András, István Nagy (147904), Vilmos Tubak (455817), Kemény Lajos, Kondorosi, Éva, András Szász, Zoltán Hegedűs (455815), Tubak Vilmos, Lajos Kemény, Éva Kondorosi (3507242), Kata Filkor (455814), Kondorosi Éva, Nagy István, Tubák, Vilmos, Lajos Kemény (229288), Hegedűs Zoltán, Szász András, István Nagy, Kemény, Lajos, Éva Kondorosi, Nagy, István, Filkor, Katalin, Vilmos Tubak, Filkor Kata, Hegedűs, Zoltán, András Szász (455816), Kata Filkor, Zoltán Hegedűs   +27 more
core   +2 more sources

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells [PDF]

The Journal of Experimental Medicine, 2006
The mononuclear phagocyte (MP) system is a body-wide macrophage (MΦ) and dendritic cell (DC) network, which contributes to tissue homeostasis, inflammation, and immune defense. The in vivo origins of MPs remain poorly understood. Here, we use an adoptive precursor cell transfer strategy into MP-depleted mice to establish the in vivo differentiation ...
Varol, Chen, Landsman, Limor, Fogg, Darin K., Greenshtein, Liat, Gildor, Boaz, Margalit, Raanan, Kalchenko, Vyacheslav, Geissmann, Frederic, Jung, Steffen   +8 more
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Fungal immunization potentiates CD4+ T cell-independent cDC2 responses for cross-presentation

Frontiers in Immunology
The incidence rates of fungal infections are increasing, especially in immunocompromised individuals without an FDA-approved vaccine. Accumulating evidence suggests that T cells are instrumental in providing fungal immunity.
Nitish A. Kulkarni, Som G. Nanjappa, Som G. Nanjappa   +2 more
doaj   +1 more source

Interaction of Type 1 Porcine Reproductive and Respiratory Syndrome Virus With In Vitro Derived Conventional Dendritic Cells

Frontiers in Immunology, 2021
The present study delineates the interaction of a typical PRRSV1.1 isolate 3267 (moderate virulence) with in vitro derived pig conventional dendritic cells, cDC1, cDC2, and a CD14+ population (designated as CD14+ DCs).
Yanli Li, Enric Mateu, Enric Mateu
doaj   +1 more source

Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells [PDF]

, 2007
Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens
Owain R Millington, Bernd H. Zinselmeyer, Zinselmeyer Bernd H, Brewer James M, Paul Garside, Rush, Catherine M., Rush, C.M., Owain R. Millington, Millington, O.R., Vivienne B Gibson, Catherine M. Rush, Bernd H Zinselmeyer, Rush, C., R. Stephen Phillips, Gibson, V.B., Vivienne B. Gibson, Phillips, R.S., R Stephen Phillips, Catherine M Rush, Zinselmeyer, B.H., Millington, Owain R., Brewer, James M., Gibson Vivienne B, Millington Owain R, Brewer, J.M., Gibson, Vivienne B., Phillips R. Stephen, Garside Paul, Rush Catherine M, Phillips, R. Stephen, Zinselmeyer, Bernd H., Garside, P., James M. Brewer, Garside, Paul, James M Brewer   +34 more
core   +1 more source