Results 81 to 90 of about 6,856,628 (321)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

IRF8-Dependent Type I Conventional Dendritic Cells (cDC1s) Control Post-Ischemic Inflammation and Mildly Protect Against Post-Ischemic Acute Kidney Injury and Disease

Frontiers in Immunology, 2021
Post-ischemic acute kidney injury and disease (AKI/AKD) involve acute tubular necrosis and irreversible nephron loss. Mononuclear phagocytes including conventional dendritic cells (cDCs) are present during different phases of injury and repair, but the ...
Na Li, Na Li, Stefanie Steiger, Lingyan Fei, Chenyu Li, Chongxu Shi, Natallia Salei, Natallia Salei, Barbara U. Schraml, Barbara U. Schraml, Zhihua Zheng, Hans-Joachim Anders, Julia Lichtnekert   +12 more
doaj   +1 more source

Human lung conventional dendritic cells orchestrate lymphoid neogenesis during COPD

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale Emerging evidence supports a crucial role for tertiary lymphoid organs (TLOs) in chronic obstructive pulmonary disease (COPD) progression. However, mechanisms of immune cell activation leading to TLO in COPD remain to be defined.
T. Naessens, Yannick Morias, Eva Hamrud, U. Gehrmann, Ramachandramouli Budida, J. Mattsson, Tina L. Baker, Gabriel Skogberg, E. Israelsson, Kristofer Thorn, Martijn J. Schuijs, B. Angermann, Faye Melville, K. Staples, D. Cunoosamy, B. Lambrecht   +15 more
semanticscholar   +1 more source

A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infections [PDF]

, 2007
Mycobacterium tuberculosis (M. tuberculosis) is responsible for 2 million deaths annually. In recent years co-infection with HIV and drug-resistant strains has led to the increase in clinical cases of tuberculosis.
Krishnan, Nitya
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Therapeutic dendritic cell vaccination against human papillomavirus [PDF]

, 2009
Cervical cancer, which is caused by infection with human papillomavirus (HPV), is the second most common cancer among women worldwide, leading to 230000 deaths annually.
Nurkkala Karlsson, Merja
core   +1 more source

The Role of Tolerogenic Dendritic Cell Therapy in Autoimmune Diseases

مجله دانشکده پزشکی اصفهان, 2018
Dendritic cells (DCs) are special antigen-presenting cells that are important for activation of immune response and tolerance. Dendritic cells have been divided in two subtypes of conventional and plasmacytoid dendritic cells.
Maryam Shahidi, Seyed Mahmoud Hashemi, Davar Amani, Kaveh Baghaei   +3 more
doaj   +1 more source

TGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors and Directs Subset Specification toward Conventional Dendritic Cells [PDF]

The Journal of Immunology, 2010
Abstract Dendritic cells (DCs) in lymphoid tissue comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs) that develop from common DC progenitors (CDPs). CDPs are Flt3+c-kitintM-CSFR+ and reside in bone marrow. In this study, we describe a two-step culture system that recapitulates DC development from c-kithiFlt3−/lo multipotent ...
Piritta, Felker, Kristin, Seré, Qiong, Lin, Christiane, Becker, Mihail, Hristov, Thomas, Hieronymus, Martin, Zenke   +6 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

TRANSITIONAL DENDRITIC CELLS ARE DISTINCT FROM CONVENTIONAL DC2 PRECURSORS AND MEDIATE PRO-INFLAMMATORY ANTIVIRAL RESPONSES

Nature Immunology, 2023
High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs), including a population of transitional DCs (tDCs) in mice and humans. However, the origin and relationship of tDCs to other DC subsets has been unclear.
F. B. Sulczewski, R. Maqueda-Alfaro, M. Alcántara-Hernández, Oriana A. Perez, Sanjana Saravanan, T. Yun, David Seong, Rebeca Arroyo Hornero, Hayley M. Raquer-McKay, E. Esteva, Zachary R. Lanzar, Rebecca A Leylek, Nicholas M. Adams, Annesa Das, Adeeb H. Rahman, Andres Gottfried-Blackmore, B. Reizis, J. Idoyaga   +17 more
semanticscholar   +1 more source