Results 61 to 70 of about 6,856,628 (321)

CD14 Expressing Precursors Give Rise to Highly Functional Conventional Dendritic Cells for Use as Dendritic Cell Vaccine [PDF]

Cancers, 2021
Induction of long-lasting immunity by dendritic cells (DCs) makes them attractive candidates for anti-tumor vaccination. Although DC vaccinations are generally considered safe, clinical responses remain inconsistent in clinical trials. This initiated studies to identify subsets of DCs with superior capabilities to induce effective and memory anti-tumor
Maud Plantinga, Denise A. M. H. van den Beemt, Ester Dünnebach, Stefan Nierkens   +3 more
openaire   +2 more sources

Dendritic Cell and Regulatory T Cell numbers in relation to Breast Cancer Progression and Metastasis [PDF]

International Journal of Medical Arts
Background: Breast cancer ranks as the second cause of cancer-related deaths in Egypt. Numerous immunomodulatory pathways underscore the immune system’s involvement in cancer prognosis.
Walaa Ashry, Amal Ayoub, Azza Ghanem, Amany Tawfeik, Effat Hassan   +4 more
doaj   +1 more source

Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo

Antibodies, 2022
Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical tools ...
Jessica Bourque, Daniel Hawiger
doaj   +1 more source

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

eLife, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent infection. With advancing age the
Marisa Stebegg, Alexandre Bignon, Danika L. Hill, Alyssa Silva-Cayetano, C. Krueger, I. Vanderleyden, S. Innocentin, L. Boon, Jiong Wang, M. Zand, J. Dooley, J. Clark, A. Liston, E. Carr, M. Linterman   +14 more
semanticscholar   +1 more source

Mechanisms and consequences of reduced dendritic growth of cerebellar Purkinje cells [PDF]

, 2012
The cerebellum is a brain region crucial for coordination and motor learning. Being the principal output cell of the cerebellar cortex, Purkinje cell loss and degeneration play an important role in many cerebellar diseases.
Gugger, Olivia S.
core   +1 more source

Progenitors of distinct lineages shape the diversity of mature type 2 conventional dendritic cells.

Immunity
Conventional dendritic cells (cDC) are antigen-presenting cells comprising cDC1 and cDC2, responsible for priming naive CD8+ and CD4+ T cells, respectively.
P. F. Rodrigues, Tihana Trsan, Grozdan Cvijetic, Darya Khantakova, Santosh K. Panda, Zhao-Yuan Liu, Florent Ginhoux, M. Cella, Marco Colonna   +8 more
semanticscholar   +1 more source

Postnatal development of dendritic calcium signaling in rat hippocampal pyramidal cells [PDF]

, 2013
In CA1 pyramidal neurons, dendritic calcium transients in stratum radiatum were evoked in acute slices via backpropagating action potentials using patch clamp recordings.
Pohle, Jörg
core   +1 more source

First Genomic Analysis of Dendritic Cells from Lung and Draining Lymph Nodes in Murine Asthma

International Journal of Genomics, 2015
Asthma is the consequence of allergic inflammation in the lung compartments and lung-draining lymph nodes. Dendritic cells initiate and promote T cell response and drive it to immunity or allergy.
Thomas Tschernig, Christina Hartwig, Andreas Jeron, Quoc Thai Dinh, Marcus Gereke, Dunja Bruder   +5 more
doaj   +1 more source

Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
core   +2 more sources

Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination

Cell Reports, 2020
Summary: Plasmacytoid dendritic cells (pDCs) and type 2 conventional dendritic cells (cDC2s) are currently under evaluation for use in cancer vaccines. Although both DC subsets can activate adaptive and innate lymphocytes, their capacity to recruit such ...
Jasper J.P. van Beek, Georgina Flórez-Grau, Mark A.J. Gorris, Till S.M. Mathan, Gerty Schreibelt, Kalijn F. Bol, Johannes Textor, I. Jolanda M. de Vries   +7 more
doaj   +1 more source