Results 1 to 10 of about 6,707 (145)

In Situ Hydrogel Modulates cDC1‐Based Antigen Presentation and Cancer Stemness to Enhance Cancer Vaccine Efficiency

Advanced Science
Effective presentation of antigens by dendritic cells (DC) is essential for achieving a robust cytotoxic T lymphocytes (CTLs) response, in which cDC1 is the key DC subtype for high‐performance activation of CTLs.
Na Zhang
exaly   +2 more sources

ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors

OncoImmunology
Conventional type 1 dendritic cells (cDC1) are critical regulators of anti-tumoral T-cell responses. The structure and abundance of intercellular contacts between cDC1 and CD8 T cells in cancer tissues is important to determine the outcome of the T-cell ...
Federica Benvenuti
exaly   +3 more sources

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis [PDF]

Frontiers in Immunology
IntroductionMultiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS), in which various immune cells contribute to disease progression, yet the role of dendritic cells (DCs) remains incompletely understood ...
Xingyu Rong, Hai Wang, Shintaro Muraoka, Takuya Uehata, Masanori Yoshinaga, Tsuneyasu Kaisho, Osamu Takeuchi   +6 more
doaj   +2 more sources

Importance of EMT Factor ZEB1 in cDC1 “MutuDC Line” Mediated Induction of Th1 Immune Response

Frontiers in Immunology, 2018
The role of Epithelial to Mesenchymal Transition (EMT) factor Zeb1 is well defined in metastasis and cancer progression but it's importance in dendritic cells (DCs) is unexplored until now. For the first time we report here that Zeb1 controls immunogenic
Sunil Kumar Raghav, Marianna M Koga, Arup Ghosh   +2 more
exaly   +3 more sources

γδ T cell-mediated activation of cDC1 orchestrates CD4+ Th1 cell priming in malaria

Frontiers in Immunology
γδ T cells facilitate the CD4+ T helper 1 (Th1) cell response against Plasmodium infection by activating conventional dendritic cells (cDCs), although the underlying mechanism remains elusive.
Katsuyuki Yui, Shin-Ichi Inoue, Taiki Aoshi   +2 more
exaly   +3 more sources

Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells

iScience, 2021
Summary: Successful immune responses rely on a regulated delivery of the right signals to the right cells at the right time. Here we show that natural killer (NK) and dendritic epidermal γδ T cells (DETCs) use similar mechanisms to spatiotemporally ...
Sonia Ghilas, Marc Ambrosini, Jean-Charles Cancel, Carine Brousse, Marion Massé, Hugues Lelouard, Marc Dalod, Karine Crozat   +7 more
doaj   +1 more source

Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis

Frontiers in Immunology, 2022
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions.
Izumi Sasaki, Takashi Kato, Hiroaki Hemmi, Hiroaki Hemmi, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Asumi Yamamoto, Tsuneyasu Kaisho   +7 more
doaj   +1 more source

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

iScience, 2021
Summary: Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated ...
Samuel W. Lukowski, Inga Rødahl, Samuel Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle Belz, Ian H. Frazer, Janin Chandra   +11 more
doaj   +1 more source

Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells

Frontiers in Immunology, 2023
A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu. Here, we challenge
Adan Chari Jirmo, Adan Chari Jirmo, Ruth Grychtol, Ruth Grychtol, Svenja Gaedcke, Bin Liu, Stephanie DeStefano, Christine Happle, Christine Happle, Olga Halle, Olga Halle, Joao T. Monteiro, Joao T. Monteiro, Anika Habener, Anika Habener, Oliver D. Breiholz, David DeLuca, Gesine Hansen, Gesine Hansen, Gesine Hansen   +19 more
doaj   +1 more source

Enhancing the immunogenicity of cancer vaccines by harnessing CLEC9A

Human Vaccines & Immunotherapeutics, 2022
Dendritic cell (DC) vaccines are a safe and effective means of inducing tumor immune responses, however, a better understanding of DC biology is required in order to realize their full potential.
M. H. Lahoud, K. J. Radford
doaj   +1 more source