Results 1 to 10 of about 7,441 (126)

Magnetic Thermal Ablation Combined with Temporally Coordinated CpG Immunotherapy Promotes cDC1‐Dependent Immune Priming in Hepatocellular Carcinoma [PDF]

Advanced science
Novel PLA@Fe3O4 magnetic microspheres were developed for transarterial magnetic hyperthermia ablation (MTA) of hepatocellular carcinoma. While destroying local tumors and inducing immunogenic cell death (ICD), MTA combined with early CpG adjuvant administration significantly promotes cDC1‐dependent immune priming. This synergistic mechanism effectively
Yang J, Yang N, Ji S, Meng S, Wang D, Liang W, Bai X, Jin Y, Sun X.   +8 more
europepmc   +2 more sources

Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8+ T cell differentiation [PDF]

Nature Communications
Maintaining a balanced immunity between pathogen defense and tolerance to environmental antigens in neonates is essential for survival and the establishment of life-long immune homeostasis.
Doğuş Altunöz, Ramin Shakiba, Kaushikk Ravi Rengarajan, Hamsa Narasimhan, Nikos E. Papaioannou, Sadiq Nasrah, Jessica Vetters, Maria L. Richter, María Parra Reyes, Nadine Nuschele, Denise Messerer, Sabine Schwamberger, Andreas Goschin, Dimitrios Starfas, Melanie Schmid, Tobias Straub, Michele Proietti, Katrin Böttcher, Maria Colomé-Tatché, Dirk Haller, Jan P. Böttcher, Stephanie C. Ganal-Vonarburg, Sophie Janssens, Christian Schulz, Anne B. Krug, Barbara U. Schraml   +25 more
doaj   +2 more sources

ALCAM-Mediated cDC1 CD8 T Cells Interactions Are Suppressed in Advanced Lung Tumors

OncoImmunology
Conventional type 1 dendritic cells (cDC1) are critical regulators of anti-tumoral T-cell responses. The structure and abundance of intercellular contacts between cDC1 and CD8 T cells in cancer tissues is important to determine the outcome of the T-cell ...
Federica Benvenuti, Lucia Lopez, Giannino Del Sal   +2 more
exaly   +3 more sources

In situ reprogramming of glioma stem cells into dendritic cell-like cells for glioblastoma immunotherapy [PDF]

Nature Communications
Immunotherapy has revolutionized the treatment landscape for many cancers, but fails to improve the outcomes of glioblastoma multiforme (GBM), in which low tumor antigen presentation restricts the recognition and eradication of cancerous cells by ...
Chunwei Tang, Weiyi Sun, Zhenmei Yang, Xiaotian Zhao, Jian Gao, Kun Han, Zichao Yao, Xianghui Dong, Miaoyan Liu, Jing Zhang, Zhaoyu Chen, Xiao Yue, Zhipeng Fu, Yan Wang, Maosen Han, Ying Liu, Jinxin Gao, Yulin Zhang, Xinyi Jiang, Chen Chen, Xin Wen, Kun Zhao, Jingyi Han   +22 more
doaj   +2 more sources

In Situ Hydrogel Modulates cDC1-Based Antigen Presentation and Cancer Stemness to Enhance Cancer Vaccine Efficiency

Advanced Science
Effective presentation of antigens by dendritic cells (DC) is essential for achieving a robust cytotoxic T lymphocytes (CTLs) response, in which cDC1 is the key DC subtype for high‐performance activation of CTLs.
Shijun Yuan, Na Zhang, Shunli Fu
exaly   +2 more sources

Conventional type-1 DC density is associated with checkpoint inhibitor response across multiple types of cancer [PDF]

The Journal of Clinical Investigation
Conventional type-1 dendritic cells (cDC1) are the main mediators of crosspresentation of tumor antigens to CD8+ T cells and provide a context of costimulatory molecules and cytokines that lead to cytotoxic T lymphocyte (CTL) responses.
Alvaro Lopez-Janeiro, José González-Gomariz, Fadi Issa, Joanna Hester, Angelo Porciuncula, Alvaro Teijeira, Carlos Luri-Rey, David Ruiz-Guillamon, Jose Luis Perez-Gracia, Elisabeth Perez-Ruiz, Isabel Barragan, Salvador Martín-Algarra, Miguel F. Sanmamed, Ignacio Ortego, Maria E. Rodriguez-Ruiz, Raluca Alexandru, Inmaculada Rodriguez, Saioa Arrieta-Aranzueque, David Rimm, Thazin Aung, Kurt A. Schalper, Carlos E. de Andrea, Ignacio Melero   +22 more
doaj   +2 more sources

A proposed convergent molecular chain linking senescence, cancer, and chronic infection to a correctable failure of dendritic cell instruction [PDF]

Frontiers in Immunology
BackgroundThree convergent phenomena in biomedical research have lacked a unified mechanistic explanation: the dendritic cell dysfunction of aging, the immune evasion of cancer, and the tolerogenic bias of chronic infection.
Andrew Caravello, Andrew Blidy
doaj   +2 more sources

Targeting BCL9/BCL9L Enhances Antigen Presentation by Promoting Conventional Type 1 Dendritic Cell (cDC1) Activation and Tumor Infiltration

Signal Transduction and Targeted Therapy
Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against cancer ...
Ming-Wei Wang, Rina Rosin-Arbesfeld, Zhongen Wu   +2 more
exaly   +2 more sources

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer [PDF]

Advanced Science
Cancer vaccines have demonstrated initial effectiveness in the treatment of human cancers, still the low mutational burden, which leads to a deficiency of well‐characterized antigens expressed within tumors capable of mediating tumor rejection, poses a ...
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
doaj   +2 more sources

c-MET Inhibition Is Accompanied by PD-L1 Upregulation and Immunosuppression-Related Tumor Microenvironment Changes in Esophageal Squamous Cell Carcinoma, With Enhanced Antitumor Activity in Combination With Anti-PD-1 Therapy. [PDF]

Cancer Med
ABSTRACT Background c‐MET is implicated in ESCC progression, but whether c‐MET inhibition reshapes immune checkpoint expression and the tumor immune microenvironment remains unclear. Methods ESCC cell lines were treated with Tepotinib, and c‐MET and PD‐L1 expression were examined by Western blotting and immunofluorescence.
Song C, Xia Z, Wang H, Wang X, Li J, Wang B, Feng C, Xie B.   +7 more
europepmc   +2 more sources