Results 1 to 10 of about 8,545 (211)

ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors [PDF]

OncoImmunology
Conventional type 1 dendritic cells (cDC1) are critical regulators of anti-tumoral T-cell responses. The structure and abundance of intercellular contacts between cDC1 and CD8 T cells in cancer tissues is important to determine the outcome of the T-cell ...
Federica Benvenuti, Giannino del Sal
exaly   +4 more sources

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer [PDF]

Advanced Science
Cancer vaccines have demonstrated initial effectiveness in the treatment of human cancers, still the low mutational burden, which leads to a deficiency of well‐characterized antigens expressed within tumors capable of mediating tumor rejection, poses a ...
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
doaj   +3 more sources

In Situ Hydrogel Modulates cDC1‐Based Antigen Presentation and Cancer Stemness to Enhance Cancer Vaccine Efficiency

Advanced Science
Effective presentation of antigens by dendritic cells (DC) is essential for achieving a robust cytotoxic T lymphocytes (CTLs) response, in which cDC1 is the key DC subtype for high‐performance activation of CTLs.
Na Zhang
exaly   +3 more sources

Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8+ T cell differentiation [PDF]

Nature Communications
Maintaining a balanced immunity between pathogen defense and tolerance to environmental antigens in neonates is essential for survival and the establishment of life-long immune homeostasis.
Doğuş Altunöz, Ramin Shakiba, Kaushikk Ravi Rengarajan, Hamsa Narasimhan, Nikos E. Papaioannou, Sadiq Nasrah, Jessica Vetters, Maria L. Richter, María Parra Reyes, Nadine Nuschele, Denise Messerer, Sabine Schwamberger, Andreas Goschin, Dimitrios Starfas, Melanie Schmid, Tobias Straub, Michele Proietti, Katrin Böttcher, Maria Colomé-Tatché, Dirk Haller, Jan P. Böttcher, Stephanie C. Ganal-Vonarburg, Sophie Janssens, Christian Schulz, Anne B. Krug, Barbara U. Schraml   +25 more
doaj   +3 more sources

Batf3-dependent orchestration of the robust Th1 responses and fungal control during cryptococcal infection, the role of cDC1

MBio
While type I conventional dendritic cells (cDC1s) are vital for generating adaptive immunity against intracellular pathogens and tumors, their role in defense against fungal pathogen Cryptococcus neoformans remains unclear.
Michal Olszewski, Jintao Xu, Christine M Freeman   +2 more
exaly   +4 more sources

Conventional type-1 DC density is associated with checkpoint inhibitor response across multiple types of cancer [PDF]

The Journal of Clinical Investigation
Conventional type-1 dendritic cells (cDC1) are the main mediators of crosspresentation of tumor antigens to CD8+ T cells and provide a context of costimulatory molecules and cytokines that lead to cytotoxic T lymphocyte (CTL) responses.
Alvaro Lopez-Janeiro, José González-Gomariz, Fadi Issa, Joanna Hester, Angelo Porciuncula, Alvaro Teijeira, Carlos Luri-Rey, David Ruiz-Guillamon, Jose Luis Perez-Gracia, Elisabeth Perez-Ruiz, Isabel Barragan, Salvador Martín-Algarra, Miguel F. Sanmamed, Ignacio Ortego, Maria E. Rodriguez-Ruiz, Raluca Alexandru, Inmaculada Rodriguez, Saioa Arrieta-Aranzueque, David Rimm, Thazin Aung, Kurt A. Schalper, Carlos E. de Andrea, Ignacio Melero   +22 more
doaj   +2 more sources

A proposed convergent molecular chain linking senescence, cancer, and chronic infection to a correctable failure of dendritic cell instruction [PDF]

Frontiers in Immunology
BackgroundThree convergent phenomena in biomedical research have lacked a unified mechanistic explanation: the dendritic cell dysfunction of aging, the immune evasion of cancer, and the tolerogenic bias of chronic infection.
Andrew Caravello, Andrew Blidy
doaj   +2 more sources

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation. [PDF]

Adv Sci (Weinh)
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Kitelinger LE, DeWitt MR, Van Wagoner CM, Conarroe CA, Funk CC, Streit AB, Kim A, Price RJ, Bullock TNJ.   +8 more
europepmc   +2 more sources

Aptamer-Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer. [PDF]

Adv Sci (Weinh)
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Wang J, Wang X, Dai X, Tian L, Shen W, Liu X, Xue W, Pan J, Yang Y.   +8 more
europepmc   +2 more sources

γδ T cell-mediated activation of cDC1 orchestrates CD4+ Th1 cell priming in malaria

Frontiers in Immunology
γδ T cells facilitate the CD4+ T helper 1 (Th1) cell response against Plasmodium infection by activating conventional dendritic cells (cDCs), although the underlying mechanism remains elusive.
Shin-Ichi Inoue
exaly   +3 more sources