Results 41 to 50 of about 9,042 (190)

Are Conventional Type 1 Dendritic Cells Critical for Protective Antitumor Immunity and How?

Frontiers in Immunology, 2019
Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to orchestrate their expansion, functional polarization and effector activity in non-lymphoid tissues or in their draining lymph nodes.
Jean-Charles Cancel, Karine Crozat, Marc Dalod, Raphaël Mattiuz   +3 more
doaj   +1 more source

The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27

, 1996
cdc1(+) is required for cell cycle progression in Schizosaccharomyces pombe. Cells carrying temperature-sensitive cdc1 mutants undergo cell cycle arrest when shifted to the restrictive temperature, becoming highly elongated, Here we describe the cloning ...
Moreno, S, MacNeill, Stuart Andrew, Fantes, PA, Reynolds, N, Nurse, P, MacNeill, Stuart Andrew; id_orcid   +5 more
core   +3 more sources

cDC1s: New Orchestrators of Tissue Innate Immunity

Trends in Immunology, 2019
Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity. Using single-cell sequencing, Ginhoux and colleagues (Immunity 2019;50:1069-1083.e8) find that a subset of activated cDC1s in bacteria-infected skin is critical for neutrophil recruitment via the production of VEGF-α.
del Fresno, Carlos, Sancho, David
openaire   +3 more sources

Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

eLife
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong, Le Yang, Kexin He, Yanrong Gu, Binhui Zhou, Tingting Jia, Toby Lawrence, Marie Malissen, Guixue Wang, Rong Huang, Hui Wang, Bernard Malissen, Yinming Liang, Lichen Zhang   +16 more
doaj   +1 more source

Longitudinal analysis of DC subsets in patients with ovarian cancer: Implications for immunotherapy

Frontiers in Immunology, 2023
BackgroundThe use of circulating cDC1 to generate anti-cancer vaccines is among the most promising approaches to overcome the limited immunogenicity and clinical efficacy of monocyte-derived DC.
Beatris Mastelic-Gavillet, Beatris Mastelic-Gavillet, Apostolos Sarivalasis, Leyder Elena Lozano, Leyder Elena Lozano, Sebastien Lofek, Sebastien Lofek, Tania Wyss, Tania Wyss, Tania Wyss, Ignacio Melero, Ignacio Melero, Ignacio Melero, Ignacio Melero, I. Jolanda M. de Vries, Alexandre Harari, Alexandre Harari, Pedro Romero, Pedro Romero, Lana Elias Kandalaft, Lana Elias Kandalaft, Selena Viganó, Selena Viganó   +22 more
doaj   +1 more source

Display of native antigen on cDC1 that have spatial access to both T and B cells underlies efficient humoral vaccination [PDF]

, 2020
Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in
Ploegh, Hidde L, Ahmet, Fatma, Lahoud, Mireille H, Tarlinton, David M, Manton, Jonathan H, Zaid, Ali, Beattie, Lynette, Manton, Jonathan H., Mueller, Scott N., Ploegh, Hidde L., Tullett, Kirsteen M, Shortman, Ken, Hor, Jyh Liang, Davey, Gayle M., Tullett, Kirsteen M., Hitchcock, Rohan O., Devi, Sapna, Park, Hae-Young, Alonso, Sylvie, Davey, Gayle M, Kaisho, Tsuneyasu, Tan, Peck S, Hitchcock, Rohan O, Steiner, Thiago M., Heath, William R., Heath, William R, Tan, Peck S., Fernandez-Ruiz, Daniel, Steiner, Thiago M, Mueller, Scott N, Vremec, David, Kato, Yu, Tarlinton, David M., Caminschi, Irina, Ahmet, F, Fernandez Ruiz, Daniel ; https://orcid.org/, Zaid, A, Ploegh, HL, Park, HY, Manton, JH, Kaisho, T, Heath, WR, Alonso, S, Mueller, SN, Tarlinton, DM, Vremec, D, Lahoud, MH, Lahoud, Mireille H.; id_orcid, Hitchcock, RO, Tan, PS, Tullett, KM, Shortman, K, Caminschi, I, Kato, Y, Beattie, L, Fernandez-Ruiz, D, Hor, JL, Steiner, TM, Davey, GM, Devi, S   +59 more
core   +1 more source

T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment

Journal for ImmunoTherapy of Cancer, 2021
Background We previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8+ T cell rates in ...
Tanja D de Gruijl, M Petrousjka van den Tol, Bas D Koster, Rik J Scheper, Barbara G Molenkamp, Alfons JM van den Eertwegh, Mari FCM van den Hout, Berbel JR Sluijter, Paul AM van Leeuwen, Marta López González, Annelies W Turksma, Saskia Vosslamber, Ekaterina J Jordanova   +12 more
doaj   +1 more source

Human cDC1s display constitutive activation of the UPR sensor IRE1

European Journal of Immunology, 2022
AbstractThe intracellular mechanisms safeguarding DC function are of biomedical interest in several immune‐related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation of the unfolded protein response (UPR) sensor IRE1.
Paulina García‐González, Dominique Fernández, Diane Gutiérrez, Mauro Parra‐Cordero, Fabiola Osorio   +4 more
openaire   +3 more sources

STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer [PDF]

Cancers, 2020
Conventional dendritic cells (cDCs) are a critical immune population, composed of multiple subsets, and responsible for controlling adaptive immunity and tolerance. Although migratory type 1 cDCs (CD103+ cDC1s in mice) are necessary to mount CD8+ T cell-mediated anti-tumor immunity, whether and how tumors modulate CD103+ cDC1 function remain ...
Taylor T. Chrisikos, Yifan Zhou, Haiyan S. Li, Rachel L. Babcock, Xianxiu Wan, Bhakti Patel, Kathryn Newton, James J. Mancuso, Stephanie S. Watowich   +8 more
openaire   +2 more sources

NK cells orchestrate splenic cDC1 migration to potentiate antiviral protective CD8+ T cell responses

, 2020
A successful immune response relies on a tightly regulated delivery of the right signals to the right cells at the right time. Here we show that innate and innate-like lymphocytes use two mechanisms to orchestrate in time and space the functions of ...
Crozat, Karine, Lelouard, H, Ghilas, Sonia, Ambrosini, Marc, Ghilas, S, Crozat, K, Cancel, J-C, Lelouard, Hugues, Massé, M, Dalod, M, Ambrosini, M, Massé, Marion, Cancel, Jean-Charles, Dalod, Marc   +13 more
core   +1 more source