Results 41 to 50 of about 8,545 (211)

Harnessing the cDC1-NK Cross-Talk in the Tumor Microenvironment to Battle Cancer [PDF]

Frontiers in Immunology, 2021
Immunotherapeutic approaches have revolutionized the treatment of several diseases such as cancer. The main goal of immunotherapy for cancer is to modulate the anti-tumor immune responses by favoring the recognition and destruction of tumor cells. Recently, a better understanding of the suppressive effect of the tumor microenvironment (TME) on immune ...
Bödder, J., Zahan, T., van Slooten, R., Schreibelt, G., de Vries, I.J.M., de Vries, I.J.M., Flórez-Grau, G.   +6 more
openaire   +4 more sources

Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

eLife
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong, Le Yang, Kexin He, Yanrong Gu, Binhui Zhou, Tingting Jia, Toby Lawrence, Marie Malissen, Guixue Wang, Rong Huang, Hui Wang, Bernard Malissen, Yinming Liang, Lichen Zhang   +16 more
doaj   +1 more source

Longitudinal analysis of DC subsets in patients with ovarian cancer: Implications for immunotherapy

Frontiers in Immunology, 2023
BackgroundThe use of circulating cDC1 to generate anti-cancer vaccines is among the most promising approaches to overcome the limited immunogenicity and clinical efficacy of monocyte-derived DC.
Beatris Mastelic-Gavillet, Beatris Mastelic-Gavillet, Apostolos Sarivalasis, Leyder Elena Lozano, Leyder Elena Lozano, Sebastien Lofek, Sebastien Lofek, Tania Wyss, Tania Wyss, Tania Wyss, Ignacio Melero, Ignacio Melero, Ignacio Melero, Ignacio Melero, I. Jolanda M. de Vries, Alexandre Harari, Alexandre Harari, Pedro Romero, Pedro Romero, Lana Elias Kandalaft, Lana Elias Kandalaft, Selena Viganó, Selena Viganó   +22 more
doaj   +1 more source

cDC1s: New Orchestrators of Tissue Innate Immunity

Trends in Immunology, 2019
Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity. Using single-cell sequencing, Ginhoux and colleagues (Immunity 2019;50:1069-1083.e8) find that a subset of activated cDC1s in bacteria-infected skin is critical for neutrophil recruitment via the production of VEGF-α.
del Fresno, Carlos, Sancho, David
openaire   +3 more sources

NK cells orchestrate splenic cDC1 migration to potentiate antiviral protective CD8+ T cell responses

, 2020
A successful immune response relies on a tightly regulated delivery of the right signals to the right cells at the right time. Here we show that innate and innate-like lymphocytes use two mechanisms to orchestrate in time and space the functions of ...
Crozat, Karine, Lelouard, H, Ghilas, Sonia, Ambrosini, Marc, Ghilas, S, Crozat, K, Cancel, J-C, Lelouard, Hugues, Massé, M, Dalod, M, Ambrosini, M, Massé, Marion, Cancel, Jean-Charles, Dalod, Marc   +13 more
core   +1 more source

SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

Nature, 2023
Abstract Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood 1,2 . Dendritic cells (DCs), especially type-1 conventional DCs (cDC1s), mediate T cell priming and therapeutic efficacy against tumours
Chuansheng Guo, Zhiyuan You, Hao Shi, Yu Sun, Xingrong Du, Gustavo Palacios, Cliff Guy, Sujing Yuan, Nicole M. Chapman, Seon Ah Lim, Xiang Sun, Jordy Saravia, Sherri Rankin, Yogesh Dhungana, Hongbo Chi   +14 more
openaire   +2 more sources

T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment

Journal for ImmunoTherapy of Cancer, 2021
Background We previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8+ T cell rates in ...
Tanja D de Gruijl, M Petrousjka van den Tol, Bas D Koster, Rik J Scheper, Barbara G Molenkamp, Alfons JM van den Eertwegh, Mari FCM van den Hout, Berbel JR Sluijter, Paul AM van Leeuwen, Marta López González, Annelies W Turksma, Saskia Vosslamber, Ekaterina J Jordanova   +12 more
doaj   +1 more source

Display of native antigen on cDC1 that have spatial access to both T and B cells underlies efficient humoral vaccination [PDF]

, 2020
Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in
Ploegh, Hidde L, Ahmet, Fatma, Lahoud, Mireille H, Tarlinton, David M, Manton, Jonathan H, Zaid, Ali, Beattie, Lynette, Manton, Jonathan H., Lahoud, Mireille H., Mueller, Scott N., Ploegh, Hidde L., Tullett, Kirsteen M, Shortman, Ken, Hor, Jyh Liang, Davey, Gayle M., Tullett, Kirsteen M., Hitchcock, Rohan O., Devi, Sapna, Park, Hae-Young, Alonso, Sylvie, Davey, Gayle M, Kaisho, Tsuneyasu, Tan, Peck S, Hitchcock, Rohan O, Steiner, Thiago M., Heath, William R., Heath, William R, Tan, Peck S., Fernandez-Ruiz, Daniel, Steiner, Thiago M, Mueller, Scott N, Vremec, David, Kato, Yu, Tarlinton, David M., Caminschi, Irina   +34 more
core   +1 more source

ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection

, 2022
Migratory dendritic cells expressing CD103 are the targets for mucosal vaccines. These belong to either of two lineage-restricted subsets, cDC1 or cDC2 cells, which have been linked to priming of functionally distinct CD4 T cells. However, recent studies
Agace, W., Schön, Karin, Börjesson, Vanja, Lycke, Nils, Strömberg, Anneli,, Lahl, K., Arabpour, Mohammad,, Lycke, Nils Y,, Agace, William, Lebrero-Fernandez, Cristina,, Angeletti, Davide, Arabpour, Mohammad, Saelens, X., Angeletti, Davide,, Lebrero-Fernandez, Cristina, Ballegeer, M., Saelens, Xavier, Ballegeer, Marlies, Schön, Karin,, Börjesson, Vanja,, Strömberg, Anneli, Lahl, Katharina   +21 more
core   +1 more source

Functions of cDC1 in Mediating CD4+ Help for CD8+ T cells [PDF]

Classical dendritic cells (cDCs) are specialized antigen presenting cells that comprise distinct subsets distinguished by transcriptional developmental differences and in the types of immune responses they initiate. Classical type 1 dendritic cells (cDC1)
Wu, Renee
core   +1 more source