Results 51 to 60 of about 9,042 (190)

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

, 2018
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy.
Neil C. Rogers, Jan P. Böttcher, Böttcher, Jan P, Stefano Sammicheli, Erik Sahai, Sahai, Erik, Eduardo Bonavita, Hanna Blees, Sammicheli, Stefano, Cabeza-Cabrerizo, Mar, Blees, Hanna, Bonavita, Eduardo, Chakravarty, Probir, Zelenay, Santiago, Caetano Reis e Sousa, Probir Chakravarty, Rogers, Neil C, Mar Cabeza-Cabrerizo, Santiago Zelenay, Reis e Sousa, Caetano, Blees, H, Böttcher, J, Sahai, E, Rogers, N, Sammicheli, S, Reis E Sousa, C, Chakravarty, P, Cabeza-Cabrerizo, M   +27 more
core   +1 more source

Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3+CD8+ Tregs

, 2021
Although CD8+ T cell tolerance to tissue-specific antigen (TSA) is essential for host homeostasis, the mechanisms underlying peripheral cross-tolerance and whether they may differ between tissue sites remain to be fully elucidated.
Malissen, Bernard, Randall, Troy D, Gomez-Casado, Cristina,, Joeris, Thorsten, Joeris, Thorsten,, Gomez-Casado, Cristina, Holmkvist, Petra, Mowat, Allan M,, Silva-Sanchez, Aaron, Agace, William W, Mowat, Allan M., Tavernier, Simon J,, Tavernier, Simon J., Agace, William W., Klotz, Luisa, Agace, William W,, Tavernier, Simon, Agace, William, Klotz, Luisa,, Silva-Sanchez, Aaron,, Mowat, Allan M, Randall, Troy, Mowat, Allan, Holmkvist, Petra,, Malissen, Bernard,, Kotarsky, Knut,, Kotarsky, Knut, Randall, Troy D., Lund University., Tavernier, Simon J, Randall, Troy D,, Knut Kotarsky, Allan M. Mowat, Troy D. Randall, Simon J. Tavernier, Cristina Gomez-Casado, Thorsten Joeris, Aaron Silva-Sanchez, Bernard Malissen, Petra Holmkvist, William W. Agace, Luisa Klotz   +41 more
core   +1 more source

Interaction of Type 1 Porcine Reproductive and Respiratory Syndrome Virus With In Vitro Derived Conventional Dendritic Cells

Frontiers in Immunology, 2021
The present study delineates the interaction of a typical PRRSV1.1 isolate 3267 (moderate virulence) with in vitro derived pig conventional dendritic cells, cDC1, cDC2, and a CD14+ population (designated as CD14+ DCs).
Yanli Li, Enric Mateu, Enric Mateu
doaj   +1 more source

Mitochondrial OPerA: tuning retrograde signaling and empowering intratumoral cDC1s. [PDF]

Life Metab
Kushwaha B, Wang R.
europepmc   +3 more sources

SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

Nature, 2023
Abstract Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood 1,2 . Dendritic cells (DCs), especially type-1 conventional DCs (cDC1s), mediate T cell priming and therapeutic efficacy against tumours
Chuansheng Guo, Zhiyuan You, Hao Shi, Yu Sun, Xingrong Du, Gustavo Palacios, Cliff Guy, Sujing Yuan, Nicole M. Chapman, Seon Ah Lim, Xiang Sun, Jordy Saravia, Sherri Rankin, Yogesh Dhungana, Hongbo Chi   +14 more
openaire   +2 more sources

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Cross‐dressed cDC1s instruct T cells in allorecognition [PDF]

Immunology & Cell Biology, 2020
A new model has been proposed by Li et al. for the role of DC subsets in the semidirect pathway of allorecognition.
openaire   +2 more sources

IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer

, 2020
International audienceDendritic cells play a key role in the orchestration of antitumor immune responses. The cDC1 (conventional dendritic cell 1) subset has been shown to be essential for antitumor responses and response to immunotherapy, but its ...
Hubert, Margaux, Dubois, Bertrand, Kielbassa, Janice, Rodriguez, Céline, Bendriss-Vermare, Nathalie, Manh, Thien-Phong Vu, Berthet, Justine, Gobbini, Elisa, Trédan, Olivier, Caux, Christophe, Doffin, Anne-Claire, Valladeau-Guilemond, Jenny, Couillault, Coline, Sajous, Christophe, Ollion, Vincent, Treilleux, Isabelle, Dalod, Marc   +16 more
core   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3(+)/CD141(+)) dendritic cells [PDF]

, 2021
Dendritic cells (DCs) bridge the connection between innate and adaptive immunity. DCs present antigens to T cells and stimulate potent cytotoxic T-cell responses.
Buggenum, J. van, Derks, R.J.E., Giera, M., Vries, I.J.M. de, Oorschot, T. van, Basit, F., Kostidis, S., de Vries, I.J., Oorschot, T.G.M. van   +8 more
core   +1 more source