Results 51 to 60 of about 8,545 (211)

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification [PDF]

Nature Immunology, 2019
Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction are unclear. In the present study Irf8 enhancers were identified via chromatin profiling of dendritic cells and CRISPR/Cas9 genome editing was ...
Vivek Durai, Prachi Bagadia, Jeffrey M. Granja, Ansuman T. Satpathy, Devesha H. Kulkarni, Jesse T. Davidson, Renee Wu, Swapneel J. Patel, Arifumi Iwata, Tian-Tian Liu, Xiao Huang, Carlos G. Briseño, Gary E. Grajales-Reyes, Miriam Wöhner, Hiromi Tagoh, Barbara L. Kee, Rodney D. Newberry, Meinrad Busslinger, Howard Y. Chang, Theresa L. Murphy, Kenneth M. Murphy   +20 more
openaire   +2 more sources

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

, 2018
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy.
Neil C. Rogers, Jan P. Böttcher, Böttcher, Jan P, Stefano Sammicheli, Erik Sahai, Sahai, Erik, Eduardo Bonavita, Hanna Blees, Sammicheli, Stefano, Cabeza-Cabrerizo, Mar, Blees, Hanna, Bonavita, Eduardo, Chakravarty, Probir, Zelenay, Santiago, Caetano Reis e Sousa, Probir Chakravarty, Rogers, Neil C, Mar Cabeza-Cabrerizo, Santiago Zelenay, Reis e Sousa, Caetano   +19 more
core   +1 more source

IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer

, 2020
International audienceDendritic cells play a key role in the orchestration of antitumor immune responses. The cDC1 (conventional dendritic cell 1) subset has been shown to be essential for antitumor responses and response to immunotherapy, but its ...
Hubert, Margaux, Dubois, Bertrand, Kielbassa, Janice, Rodriguez, Céline, Bendriss-Vermare, Nathalie, Manh, Thien-Phong Vu, Berthet, Justine, Gobbini, Elisa, Trédan, Olivier, Caux, Christophe, Doffin, Anne-Claire, Valladeau-Guilemond, Jenny, Couillault, Coline, Sajous, Christophe, Ollion, Vincent, Treilleux, Isabelle, Dalod, Marc   +16 more
core   +1 more source

Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo

Frontiers in Immunology, 2018
Type 1 conventional DCs (cDC1) excel in the cross-priming of CD8+ T cells, which is crucial for orchestrating efficient immune responses against viruses or tumors.
Raphaël Mattiuz, Christian Wohn, Sonia Ghilas, Marc Ambrosini, Yannick O. Alexandre, Cindy Sanchez, Anissa Fries, Thien-Phong Vu Manh, Bernard Malissen, Bernard Malissen, Marc Dalod, Karine Crozat   +11 more
doaj   +1 more source

Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung

Allergology International, 2021
Background: Follicular helper T (Tfh) cells represent a unique subset of helper CD4+ T cells in lymphoid follicles. Recently, Tfh cells were shown to play an important role in asthma through B cell differentiation.
Shogo Sakurai, Kazuki Furuhashi, Ryo Horiguchi, Fumiya Nihashi, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda   +12 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27

, 1996
cdc1(+) is required for cell cycle progression in Schizosaccharomyces pombe. Cells carrying temperature-sensitive cdc1 mutants undergo cell cycle arrest when shifted to the restrictive temperature, becoming highly elongated, Here we describe the cloning ...
Moreno, S, MacNeill, Stuart Andrew, Fantes, PA, Reynolds, N, Nurse, P   +4 more
core   +3 more sources

Liposomal Nanovaccine Containing α-Galactosylceramide and Ganglioside GM3 Stimulates Robust CD8⁺ T Cell Responses via CD169⁺ Macrophages and cDC1

Vaccines, 2021
Successful anti-cancer vaccines aim to prime and reinvigorate cytotoxic T cells and should therefore comprise a potent antigen and adjuvant. Antigen targeting to splenic CD169+ macrophages was shown to induce robust CD8+ T cell responses via antigen ...
Joanna Grabowska, Dorian A. Stolk, Maarten K. Nijen Twilhaar, Martino Ambrosini, Gert Storm, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk, Joke M.M. den Haan   +8 more
doaj   +1 more source