Results 71 to 80 of about 9,042 (190)

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Carbodicarbene Monolayers on Au(111) Enable Strong Carbon(0)‐Metal Binding and Work‐Function Modulation

Small, EarlyView.
Carbodicarbene (CDC) molecules were utilized as surface ligands on Au(111) and showed higher thermal stability and work function modulation than N‐heterocyclic carbene (NHC). ABSTRACT Carbodicarbenes (CDCs), featuring a formally zero‐valent carbon atom coordinated by two N‐heterocyclic carbene (NHC) units, are exceptionally strong σ‐donor ligands in ...
Rajarshi Mondal, Joshua M. Sims, Soumyajit Rajak, Iris Berg, Shiraz Marigosian, Luca Schio, Masoumeh Alihosseini, Tzipora Ben‐Tzvi, Guido Fratesi, Luca Floreano, Nan Jiang, Carine Michel, Elad Gross   +12 more
wiley   +1 more source

Image_4_Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses.jpeg

, 2023
Historically platelets are mostly known for their crucial contribution to hemostasis, but there is growing understanding of their role in inflammation and immunity.
Maarten K. Nijen Twilhaar (11197329), Ilse Jongerius (246324), Admar Verschoor (251200), Katarzyna Olesek (5722949), Cees van Kooten (795358), Alsya J. Affandi (11197326), Joanna Grabowska (5722952), Mieke C. Brouwer (12755072), Gert Storm (21109), Valentine Léopold (17415510), Cornelis van ‘t Veer (694059), Yvette van Kooyk (7462034), Joke M. M. den Haan (7500083)   +12 more
core   +1 more source

Cdc1 Is Required for Growth and Mn2+ Regulation in Saccharomyces cerevisiae

Genetics, 1998
Abstract Cdc1 function was initially implicated in bud formation and nuclear division because cdc1(Ts) cells arrested with a small bud, duplicated DNA, and undivided nucleus. Our studies show that Cdc1 is necessary for cell growth at several stages of the cell cycle, as well as in pheromone-treated cells.
M, Paidhungat, S, Garrett
openaire   +2 more sources

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

cDC1-derived IL-27 regulates small intestinal CD4⁺ T cell homeostasis in mice

, 2022
The small intestinal lamina propria contains large numbers of IFNγ-producing T helper (Th1) cells that play important roles in intestinal homeostasis and host defense, but the mechanisms underlying their development remain poorly understood.
Mörbe, Urs, Ahmadi, Fatemeh, Agace, William W., Agace, William W,, Ashworth, Christian, Mörbe, Urs,, Ashworth, Christian,, Lappalainen, Amanda,, Lappalainen, Amanda, Kotarsky, Knut,, Kotarsky, Knut, Junghus, Fredrik, Junghus, Fredrik,, Lund University., Agace, William W, Ahmadi, Fatemeh,   +15 more
core   +1 more source

Batf3-dependent orchestration of the robust Th1 responses and fungal control during cryptococcal infection, the role of cDC1

mBio
While type I conventional dendritic cells (cDC1s) are vital for generating adaptive immunity against intracellular pathogens and tumors, their role in defense against fungal pathogen Cryptococcus neoformans remains unclear.
Jintao Xu, Rylan Hissong, Rachel Bareis, Arianna Creech, Kristie D. Goughenour, Christine M. Freeman, Michal A. Olszewski   +6 more
doaj   +1 more source

Type 1 Conventional CD103+ Dendritic Cells Control Effector CD8+ T Cell Migration, Survival, and Memory Responses During Influenza Infection

Frontiers in Immunology, 2018
Type 1 conventional CD103+ dendritic cells (cDC1) contribute significantly to the cytotoxic T lymphocyte (CTL) response during influenza virus infection; however, the mechanisms by which cDC1s promote CTL recruitment and viral clearance are unclear.
See Liang Ng, Yi Juan Teo, Yolanda Aphrilia Setiagani, Klaus Karjalainen, Christiane Ruedl   +4 more
doaj   +1 more source

Stability Modelling and Analysis of an Integrated Wind‐PV‐Storage Power System: A Small‐Signal Approach Using Multi‐Coordinate System Consistency Transformation

Energy Internet, EarlyView.
ABSTRACT With growing energy demand and depletion of fossil fuels, renewable energy development is crucial for achieving dual‐carbon goals. This paper focuses on small‐signal modelling and stability analysis of a grid‐connected wind‐PV‐storage system.
Puyu Wang, Pengyu Bo, Xujie Tang, Wu Tong, Yibo Wang, Xiance Zhu, Zhiyu Cao, Xiao‐Ping Zhang   +7 more
wiley   +1 more source

Erythropoietin receptor on cDC1s dictates immune tolerance

Nature
Type 1 conventional dendritic cells (cDC1s) are unique in their efferocytosis1 and cross-presenting abilities2, resulting in antigen-specific T cell immunity3 or tolerance4-8. However, the mechanisms that underlie cDC1 tolerogenic function remain largely unknown.
Xiangyue Zhang, Christopher S. McGinnis, Guotao Yu, Sijie Chen, Pingping Zheng, Christian M. Schürch, Kamir J. Hiam-Galvez, Nathan E. Reticker-Flynn, Wenhui Guo, Winnie Yao, Jingtao Qiu, Alexander Muselman, Ian L. Linde, John W. Hickey, Hao Yan, Victoria M. Tran, Wenli Qiu, Delphine Brichart-Vernos, Toshihito Hirai, Bo Yu, Xiuli An, Yanling Xiao, Helena Paidassi, Tiffany C. Scharschmidt, Michael Angelo, Dean Sheppard, Hongbo Chi, Ansuman T. Satpathy, Sing Sing Way, Bernard Malissen, Samuel Strober, Edgar G. Engleman   +31 more
openaire   +4 more sources